|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 September 2001, Vol. 98, No. 6, pp. 1949-1954
RED CELLS
Regulation of expression of murine transferrin receptor
2
Hiroshi Kawabata,
Rasha S. Germain,
Takayuki Ikezoe,
Xiangjun Tong,
Eric M. Green,
Adrian F. Gombart, and
H. Phillip Koeffler
From the Division of Hematology/Oncology, Department of
Medicine, Burns and Allen Research Institute, Cedars-Sinai Medical
Center, University of California Los Angeles School of Medicine;
and Department of Hematology/ Immunology, Kanazawa
Medical University, Uchinada-machi, Ishikawa-ken, Japan.
Complementary and genomic DNA for the murine transferrin receptor 2 (TfR2) were cloned and mapped to chromosome 5. Northern blot analysis
showed that high levels of expression of murine TfR2 occurred in the
liver, whereas expression of TfR1 in the liver was relatively low.
During liver development, TfR2 was up-regulated and TfR1 was
down-regulated. During erythrocytic differentiation of murine
erythroleukemia (MEL) cells induced by dimethylsulfoxide, expression of
TfR1 increased, whereas TfR2 decreased. In MEL cells, expression of
TfR1 was induced by desferrioxamine, an iron chelator, and it was
reduced by ferric nitrate. In contrast, levels of TfR2 were not
affected by the cellular iron status. Reporter assay showed that
GATA-1, an erythroid-specific transcription factor essential for
erythrocytic differentiation at relatively early stages, enhanced TfR2
promoter activity. Interestingly, FOG-1, a cofactor of GATA-1 required
for erythrocyte maturation, repressed the enhancement of the activity
by GATA-1. Also, CCAAT-enhancer binding protein, which is abundant in
liver, enhanced the promoter activity. Thus, tissue distribution of
TfR2 was consistent with the reporter assays. Expression profiles of
TfR2 were different from those of TfR1, suggesting unique functions for
TfR2, which may be involved in iron metabolism, hepatocyte function,
and erythrocytic differentiation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T.-S. Huang, J.-Y. Hsieh, Y.-H. Wu, C.-H. Jen, Y.-H. Tsuang, S.-H. Chiou, J. Partanen, H. Anderson, T. Jaatinen, Y.-H. Yu, et al.
Functional Network Reconstruction Reveals Somatic Stemness Genetic Maps and Dedifferentiation-Like Transcriptome Reprogramming Induced by GATA2
Stem Cells,
May 1, 2008;
26(5):
1186 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. F. Wallace, L. Summerville, E. M. Crampton, and V. N. Subramaniam
Defective trafficking and localization of mutated transferrin receptor 2: implications for type 3 hereditary hemochromatosis
Am J Physiol Cell Physiol,
February 1, 2008;
294(2):
C383 - C390.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Xu, H. L. Persson, and D. R. Richardson
Molecular Pharmacology of the Interaction of Anthracyclines with Iron
Mol. Pharmacol.,
August 1, 2005;
68(2):
261 - 271.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Tanaka, J. Zheng, K. Kitajima, K. Kita, H. Yoshikawa, and T. Nakano
Differentiation status dependent function of FOG-1
Genes Cells,
December 1, 2004;
9(12):
1213 - 1226.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Vitte, B. Davoult, N. Roblot, M. Mayer, V. Joshi, S. Courageot, F. Tronche, J. Vadrot, M. H. Moreau, F. Kemeny, et al.
Deletion of Murine Smn Exon 7 Directed to Liver Leads to Severe Defect of Liver Development Associated with Iron Overload
Am. J. Pathol.,
November 1, 2004;
165(5):
1731 - 1741.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. M. Vogt, A. D. Blackwell, A. M. Giannetti, P. J. Bjorkman, and C. A. Enns
Heterotypic interactions between transferrin receptor and transferrin receptor 2
Blood,
March 1, 2003;
101(5):
2008 - 2014.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. M. Qian, H. Li, H. Sun, and K. Ho
Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway
Pharmacol. Rev.,
December 1, 2002;
54(4):
561 - 587.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Kawabata, T. Nakamaki, P. Ikonomi, R. D. Smith, R. S. Germain, and H. P. Koeffler
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells
Blood,
November 1, 2001;
98(9):
2714 - 2719.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
