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Blood, 1 October 2001, Vol. 98, No. 7, pp. 2028-2038
PLENARY PAPER
Embryonic and hematopoietic stem cells express a novel
SH2-containing inositol 5'-phosphatase isoform that partners with the
Grb2 adapter protein
Zheng Tu,
John M. Ninos,
Zhengyu Ma,
Jia-Wang Wang,
Maria P. Lemos,
Caroline Desponts,
Tomar Ghansah,
Julie M. Howson, and
William G. Kerr
From the Immunology Program, the H. Lee Moffitt Cancer
Center and Research Institute, and the Departments of Oncology and
Biochemistry, University of South Florida, Tampa.
SH2-containing inositol 5'-phosphatase (SHIP) modulates the
activation of immune cells after recruitment to the membrane by Shc and
the cytoplasmic tails of receptors. A novel SHIP isoform of
approximately 104 kd expressed in primitive stem cell populations (s-SHIP) is described. It was found that s-SHIP is expressed in totipotent embryonic stem cells to the exclusion of the 145-kd SHIP
isoform expressed in differentiated hematopoietic cells. s-SHIP is also
expressed in primitive hematopoietic stem cells, but not in
lineage-committed hematopoietic cells. In embryonic stem cells, s-SHIP
partners with the adapter protein Grb2 without tyrosine phosphorylation
and is present constitutively at the cell membrane. It is postulated
that s-SHIP modulates the activation threshold of primitive stem cell populations.
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