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Blood, 1 October 2001, Vol. 98, No. 7, pp. 2116-2123
HEMATOPOIESIS
Histone deacetylase 3 associates with and represses the
transcription factor GATA-2
Yukiyasu Ozawa,
Masayuki Towatari,
Shinobu Tsuzuki,
Fumihiko Hayakawa,
Takahiro Maeda,
Yasuhiko Miyata,
Mitsune Tanimoto, and
Hidehiko Saito
From the First Department of Internal Medicine, Nagoya
University School of Medicine, Nagoya, Japan.
The zinc finger transcription factor GATA-2 plays a critical role
in the survival and proliferation of hematopoietic stem cells. This
study examined the interaction of GATA-2 with histone deacetylases
(HDACs) to define the involvement of HDACs in the regulation of GATA-2
function. GATA-2 directly associates with HDAC3 but not with HDAC1.
Consistent with this, HDAC3 suppressed the transcriptional potential of
GATA-2, whereas HDAC1 did not affect GATA-2-dependent transcription.
Results further demonstrated that GATA-2 and HDAC3 colocalized in the
nucleus. These results identify GATA-2 as a nuclear target for
HDAC3-mediated repression. Furthermore, GATA-2 also directly
associated with HDAC5 but not with other class II HDACs examined, that
is, HDAC4 and HDAC6. This is the first demonstration that a
tissue-specific transcription factor directly and selectively interacts
with HDAC3 and HDAC5 among HDAC family members.
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