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Blood, 1 October 2001, Vol. 98, No. 7, pp. 2134-2142
HEMATOPOIESIS
ALCAM (CD166): its role in hematopoietic and endothelial
development
Osamu Ohneda,
Kinuko Ohneda,
Fumio Arai,
James Lee,
Takeshi Miyamoto,
Yoshimi Fukushima,
Donald Dowbenko,
Laurence A. Lasky, and
Toshio Suda
From the Department of Cell Differentiation, Institute
of Molecular Embryology and Genetics, Kumamoto University, Japan;
Center for Tsukuba Advanced Research Alliance and Institute of Basic
Medical Sciences, University of Tsukuba, Japan; and Department of
Molecular Biology and Molecular Oncology, Genentech, South San
Francisco, CA.
A critical role for the endothelium of yolk sac and dorsal aorta
has been shown in embryonic hematopoiesis. A stromal cell line derived
from yolk sac, YSCL-72, has been chosen to search for a novel molecule
associated with embryonic hematopoiesis. Analysis between YSCL-72 and
an adult aorta-derived endothelial cell line, EOMA, demonstrated that
activated leukocyte cell adhesion molecule (ALCAM, or CD166) was
specifically expressed in YSCL-72 but not in EOMA. Immunohistochemical
study showed that ALCAM was expressed in the endothelium of yolk sac
and dorsal aorta but not in adult aorta. ALCAM-transfected EOMA cells
supported development of hematopoietic progenitor cells compared with
vector-transfected EOMA cells, suggesting that ALCAM
appeared to be crucial for hematopoiesis. In addition, ALCAM was found
to be involved in capillary tube formation and hemangioblast
differentiation. Taken together with these findings, ALCAM is
highly associated not only with embryonic hematopoiesis but also vasculoangiogenesis.
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