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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fasching, K. Articles by Panzer-Grümayer, E. R. Search for Related Content PubMed PubMed Citation Articles by Fasching, K. Articles by Panzer-Grümayer, E. R. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 October 2001, Vol. 98, No. 7, pp. 2272-2274 BRIEF REPORT Presence of N regions in the clonotypic DJ rearrangements of the immunoglobulin heavy-chain genes indicates an exquisitely short latency in t(4;11)-positive infant acute lymphoblastic leukemia Karin Fasching, Simon Panzer, Oskar A. Haas, Arndt Borkhardt, Rolf Marschalek, Frank Griesinger, and E. Renate Panzer-Grümayer From the Children's Cancer Research Institute, St Anna Kinderspital, and Clinic for Blood Group Serology, University of Vienna, Austria; the Department of Pediatric Hematology/Oncology, Justus Liebig Universität, Giessen, Institute of Pharmaceutical Biology, University of Frankfurt; and the Department of Hematology/Oncology, University of Göttingen, Germany Childhood acute lymphoblastic leukemia (ALL) is frequently initiated in utero at a time of developmentally regulated insertion of N regions into the DJH rearrangements of immunoglobulin heavy-chain (IgH) genes. Here it is shown that N regions are present in the clonotypic DJH rearrangements in 11 of 12 infant ALLs with t(4;11). These data are compared with the 122 previously published DJH sequences and were found to have a pattern similar to that of ALL in children older than 3 years at diagnosis but were unlike that in children younger than 3 years who predominantly lack N regions. These findings, therefore, indicate that t(4;11)-positive infant ALL is initiated later in fetal development than most B-cell precursor ALL from children younger than 3 years and that they have a shorter latency period already in utero. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. G. Spector, A. J. Hooten, and J. A. Ross Ontogeny of Gene Expression: A Changing Environment for Malignancy Cancer Epidemiol. Biomarkers Prev., May 1, 2008; 17(5): 1021 - 1023. [Full Text] [PDF] M. S. Pombo-de-Oliveira, S. Koifman, and Brazilian Collaborative Study Group of Infant Acut Infant Acute Leukemia and Maternal Exposures during Pregnancy Cancer Epidemiol. Biomarkers Prev., December 1, 2006; 15(12): 2336 - 2341. [Abstract] [Full Text] [PDF] M. Konrad, M. Metzler, S. Panzer, I. Ostreicher, M. Peham, R. Repp, O. A. Haas, H. Gadner, and E. R. Panzer-Grumayer Late relapses evolve from slow-responding subclones in t(12;21)-positive acute lymphoblastic leukemia: evidence for the persistence of a preleukemic clone Blood, May 1, 2003; 101(9): 3635 - 3640. [Abstract] [Full Text] [PDF] J. L. Wiemels, B. C. Leonard, Y. Wang, M. R. Segal, S. P. Hunger, M. T. Smith, V. Crouse, X. Ma, P. A. Buffler, and S. R. Pine Site-specific translocation and evidence of postnatal origin of the t(1;19) E2A-PBX1 fusion in childhood acute lymphoblastic leukemia PNAS, November 12, 2002; 99(23): 15101 - 15106. [Abstract] [Full Text] [PDF]

	Copyright © 2001 by American Society of Hematology         Online ISSN: 1528-0020