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Blood, 15 October 2001, Vol. 98, No. 8, pp. 2345-2351
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Relationship between transferrin saturation and iron
stores in the African American and US Caucasian populations: analysis
of data from the third National Health and Nutrition Examination
Survey
Christine E. McLaren,
Kuo-Tung Li,
Victor R. Gordeuk,
Victor Hasselblad, and
Gordon D. McLaren
From the Divisions of Epidemiology and
Hematology/Oncology, University of California, Irvine, College of
Medicine, Irvine; Biostatistics Shared Resource, Chao Family
Comprehensive Cancer Center, University of California, Irvine; Center
for Sickle Cell Disease, Howard University, Washington, DC; Center for
Health Policy Research and Education, Duke University, Durham, NC; and
Veterans Affairs Long Beach Health Care System, Long Beach, CA.
In previous analyses of transferrin saturation data in African
Americans and Caucasians from the second National Health and Nutrition
Examination Survey (NHANES II), subpopulations were found consistent
with population genetics for common loci that influence iron
metabolism. The goal of this new study was to determine if these
transferrin saturation subpopulations have different levels of iron
stores. Statistical mixture modeling was applied to transferrin
saturation data for African Americans and Caucasians from the third
National Health and Nutrition Examination Survey (NHANES III), and then
the mean serum ferritin concentrations were determined for the
transferrin saturation subpopulations that were identified. After
adjustment for diurnal variation, 3 subpopulations of transferrin
saturation were identified in each racial group. Satisfying
Hardy-Weinberg conditions for major locus effects, in both racial
groups the sum of the square roots of the proportion with the lowest
mean transferrin saturation and the proportion with the highest mean
transferrin saturation was approximately 1. When weighted to reflect
the US adult population as a whole, these subpopulations of increasing
transferrin saturations had progressively increasing mean age-adjusted
serum ferritin concentration values in each ethnic grouping as
stratified by sex (trend test, P < .002 for all). These
results are consistent with the concept that population transferrin
saturation subpopulations reflect different levels of storage iron.
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