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Related Collections Immunobiology Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 October 2001, Vol. 98, No. 8, pp. 2574-2576 BRIEF REPORT Loss of blood CD11c+ myeloid and CD11c plasmacytoid dendritic cells in patients with HIV-1 infection correlates with HIV-1 RNA virus load Heather Donaghy, Anton Pozniak, Brian Gazzard, Nad Qazi, Jill Gilmour, Frances Gotch, and Steven Patterson From the Department of Immunology, Imperial College School of Medicine, and the Department of HIV/GU Medicine at Chelsea and Westminster Hospital, London, United Kingdom. Human blood contains at least 2 subpopulations of antigen-presenting dendritic cells (DCs) that can be differentiated by their expression of CD11c. Myeloid DCs (myDCs), which are CD11c+, trap invading pathogens in the tissues and then migrate to lymphoid tissues where they stimulate pathogen-specific T-cell responses. Plasmacytoid DCs (pcDCs), which are CD11c, secrete interferon- in response to viral infections. This study reports that in HIV-1 infection there is a progressive depletion of both these DC populations and that this correlates with an increasing HIV-1 plasma virus load. The median numbers of myDCs and pcDCs were 6978/mL and 9299/mL, respectively, in healthy male controls and 2298/mL and 1640/mL, respectively, in patients with more than 105 HIV-1 RNA copies/mL. Both DC populations expressed CD4, CCR5, and CXCR4. The findings suggest that loss of DCs in HIV infection may contribute to disease progression. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. M. Hughes, B. Amadi, M. Mwiya, H. Nkamba, A. Tomkins, and D. Goldblatt Dendritic Cell Anergy Results from Endotoxemia in Severe Malnutrition J. Immunol., August 15, 2009; 183(4): 2818 - 2826. 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