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Related Collections Immunobiology Chemokines, Cytokines, and Interleukins Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2001, Vol. 98, No. 9, pp. 2626-2632 CHEMOKINES Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor + gut intraepithelial lymphocytes Marc-André Wurbel, Marie Malissen, Delphine Guy-Grand, Eric Meffre, Michel C. Nussenzweig, Mireille Richelme, Alice Carrier, and Bernard Malissen From the Centre d'Immunologie de Marseille-Luminy, INSERM-CNRS- Universite de la Mediterranee, Campus de Luminy, Marseille, France; the Unité de Biologie Moléculaire du Gène, INSERM U277 and Institut Pasteur, Paris, France; and the Laboratory of Molecular Immunology, The Rockefeller University, New York, NY. CC chemokine receptor (CCR) 9, the receptor for the CC-chemokine CCL25/thymus-expressed chemokine (TECK), is mainly expressed by thymocytes and by intraepithelial (IEL) and lamina propria lymphocytes of the small intestine. To study the biologic role of CCR9, a mouse strain was generated in which the CCR9 gene was deleted. In spite of the high level of CCR9 found in double- and single-positive thymocytes and of the expression of its corresponding ligand on thymic stromal cells, CCR9 deletion had no major effect on intrathymic T-cell development. It was noted that there was only a one-day lag in the appearance of double-positive cells during fetal ontogeny in CCR9/ thymi. When tested in chemotaxis assay, thymocytes isolated from CCR9/ mice failed to respond to TECK/CCL25. Taken together, these results suggest that in thymocytes, CCR9 is the only physiologic receptor for TECK/CCL25, and that it is dispensable for proper T-cell development. Bone marrow pre-pro-B cells migrate in response to TECK/CCL25, but more mature B cells do not. Consistent with this observation, it was shown that there are fewer pre-pro-B cells in CCR9/ mice than in wild-type mice. However, this diminution does not appear to have a detectable effect on the generation of a normal complement of mature B cells. Finally, it was shown that in the small intestine of CCR9-deficient mice, the intraepithelial T-cell-to-epithelial cell ratio is decreased, an observation that can be accounted for by a marked diminution of the T-cell receptor + compartment. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: K. D. C. Jensen, S. Shin, and Y.-h. Chien Cutting Edge: {gamma}{delta} Intraepithelial Lymphocytes of the Small Intestine Are Not Biased toward Thymic Antigens J. Immunol., June 15, 2009; 182(12): 7348 - 7351. 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