|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 November 2001, Vol. 98, No. 9, pp. 2720-2725
HEMATOPOIESIS
Interleukin-6 stimulates thrombopoiesis through
thrombopoietin: role in inflammatory thrombocytosis
Arthur Kaser,
Gerald Brandacher,
Wolfgang Steurer,
Susanne Kaser,
Felix A. Offner,
Heinz Zoller,
Igor Theurl,
Walter Widder,
Clemens Molnar,
Othmar Ludwiczek,
Michael B. Atkins,
James W. Mier, and
Herbert Tilg
From the Divisions of Gastroenterology and Hepatology
and of General Internal Medicine, the Department of Medicine, and the
Department of Transplant Surgery, University Hospital Innsbruck,
Austria; the Department of Pathology, Academic Teaching Hospital
Feldkirch, Austria; and the Department of Medicine, Division of
Hematology and Oncology, Beth Israel Deaconess Medical Center, Harvard
Medical School, Boston, MA.
Baseline platelet production is dependent on thrombopoietin (TPO).
TPO is constitutively produced and primarily regulated by
receptor-mediated uptake by platelets. Inflammatory thrombocytosis is
thought to be related to increased interleukin-6 (IL-6) levels. To
address whether IL-6 might act through TPO to increase platelet counts,
TPO was neutralized in vivo in C57BL/10 mice treated with IL-6,
and hepatic TPO mRNA expression and TPO plasma levels were studied.
Transcriptional regulation of TPO mRNA was studied in the
hepatoblastoma cell line HepG2. Furthermore, TPO plasma levels were
determined in IL-6-treated cancer patients. It is shown that IL-6-induced thrombocytosis in C57BL/10 mice is accompanied by enhanced hepatic TPO mRNA expression and elevated TPO plasma levels. Administration of IL-6 to cancer patients results in a corresponding increase in TPO plasma levels. IL-6 enhances TPO mRNA transcription in
HepG2 cells. IL-6-induced thrombocytosis can be abrogated by neutralization of TPO, suggesting that IL-6 induces thrombocytosis through TPO. A novel pathway of TPO regulation by the inflammatory mediator IL-6 is proposed, indicating that the number of platelets by
themselves might not be the sole determinant of circulating TPO levels
and thus of thrombopoiesis. This regulatory pathway might be of
relevance for the understanding of reactive thrombocytosis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
D. V. Gnatenko, W. Zhu, X. Xu, E. T. Samuel, M. Monaghan, M. H. Zarrabi, C. Kim, A. Dhundale, and W. F. Bahou
Class prediction models of thrombocytosis using genetic biomarkers
Blood,
January 7, 2010;
115(1):
7 - 14.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Lambert, Y. Wang, K. H. Bdeir, Y. Nguyen, M. A. Kowalska, and M. Poncz
Platelet factor 4 regulates megakaryopoiesis through low-density lipoprotein receptor-related protein 1 (LRP1) on megakaryocytes
Blood,
September 10, 2009;
114(11):
2290 - 2298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-C. Chen, C.-F. Lin, H.-Y. Lei, S.-C. Lin, H.-S. Liu, T.-M. Yeh, R. Anderson, and Y.-S. Lin
Deletion of the C-Terminal Region of Dengue Virus Nonstructural Protein 1 (NS1) Abolishes Anti-NS1-Mediated Platelet Dysfunction and Bleeding Tendency
J. Immunol.,
August 1, 2009;
183(3):
1797 - 1803.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R Laskaj, S Dodig, I Cepelak, and I Kuzman
Superoxide dismutase, copper and zinc concentrations in platelet-rich plasma of pneumonia patients
Ann Clin Biochem,
March 1, 2009;
46(2):
123 - 128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaushansky
Determinants of platelet number and regulation of thrombopoiesis
Hematology,
January 1, 2009;
2009(1):
147 - 152.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Nakazawa, S. Sato, M. Naito, Y. Kato, K. Mishima, H. Arai, T. Tsuruo, and N. Fujita
Tetraspanin family member CD9 inhibits Aggrus/podoplanin-induced platelet aggregation and suppresses pulmonary metastasis
Blood,
September 1, 2008;
112(5):
1730 - 1739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaushansky
Historical review: megakaryopoiesis and thrombopoiesis
Blood,
February 1, 2008;
111(3):
981 - 986.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Radaelli, C. Loardi, M. Cazzaniga, G. Balestri, C. DeCarlini, M. G. Cerrito, E. N. Cusa, L. Guerra, S. Garducci, D. Santo, et al.
Inflammatory Activation During Coronary Artery Surgery and Its Dose-Dependent Modulation by Statin/ACE-Inhibitor Combination
Arterioscler Thromb Vasc Biol,
December 1, 2007;
27(12):
2750 - 2755.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Brockmann, A. Giese, K. Mueller, F. j. Kaba, F. Lohr, C. Weiss, S. Gottschalk, I. Nolte, J. Leppert, J. Tuettenberg, et al.
Preoperative thrombocytosis predicts poor survival in patients with glioblastoma
Neuro Oncology,
July 1, 2007;
9(3):
335 - 342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Zhiyi, L. Wenshan, Z. Wenze, D. Ning, Z. Chi, Y. Kenan, W. Ping, W. Qianqian, and Z. Qing
Secretion Expression and Activity Assay of a Novel Fusion Protein of Thrombopoietin and Interleukin-6 in Pichia pastoris
J. Biochem.,
July 1, 2007;
142(1):
17 - 24.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Schafer
Molecular basis of the diagnosis and treatment of polycythemia vera and essential thrombocythemia
Blood,
June 1, 2006;
107(11):
4214 - 4222.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kaushansky
Lineage-specific hematopoietic growth factors.
N. Engl. J. Med.,
May 11, 2006;
354(19):
2034 - 2045.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Pick, C. Perry, T. Lapidot, C. Guimaraes-Sternberg, E. Naparstek, V. Deutsch, and H. Soreq
Stress-induced cholinergic signaling promotes inflammation-associated thrombopoiesis
Blood,
April 15, 2006;
107(8):
3397 - 3406.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. G. Romanelli, I. Petrai, G. Robino, E. Efsen, E. Novo, A. Bonacchi, G. Pagliai, A. Grossi, M. Parola, N. Navari, et al.
Thrombopoietin stimulates migration and activates multiple signaling pathways in hepatoblastoma cells
Am J Physiol Gastrointest Liver Physiol,
January 1, 2006;
290(1):
G120 - G128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E Unsal, S Aksaray, D Koksal, and T Sipit
Potential role of interleukin 6 in reactive thrombocytosis and acute phase response in pulmonary tuberculosis
Postgrad. Med. J.,
September 1, 2005;
81(959):
604 - 607.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Al-Mohanna, S. Saleh, R. S. Parhar, K. Khabar, and K. Collison
Human neutrophil gene expression profiling following xenogeneic encounter with porcine aortic endothelial cells: the occult role of neutrophils in xenograft rejection revealed
J. Leukoc. Biol.,
July 1, 2005;
78(1):
51 - 61.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Valade, F. Decailliot, Y. Rebufat, Y. Heurtematte, P. Duvaldestin, and F. Stephan
Thrombocytosis after trauma: incidence, aetiology, and clinical significance
Br. J. Anaesth.,
January 1, 2005;
94(1):
18 - 23.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Bernardo, C. Ball, L. Nolasco, J. F. Moake, and J.-f. Dong
Effects of inflammatory cytokines on the release and cleavage of the endothelial cell-derived ultralarge von Willebrand factor multimers under flow
Blood,
July 1, 2004;
104(1):
100 - 106.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. I. Schafer
Thrombocytosis
N. Engl. J. Med.,
March 18, 2004;
350(12):
1211 - 1219.
[Full Text]
[PDF]
|
|
|
|
|
