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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ng, W. F. Articles by Lechler, R. I. Search for Related Content PubMed PubMed Citation Articles by Ng, W. F. Articles by Lechler, R. I. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 November 2001, Vol. 98, No. 9, pp. 2736-2744 IMMUNOBIOLOGY Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells Wan Fai Ng, Phillip J. Duggan, Frederique Ponchel, Giuseppe Matarese, Giovanna Lombardi, A. David Edwards, John D. Isaacs, and Robert I. Lechler From the Departments of Immunology and Paediatrics, Hammersmith Campus, Imperial College School of Medicine, London, United Kingdom; and Department of Rheumatology and Molecular Medicine, University of Leeds, United Kingdom. Despite thymic deletion of cells with specificity for self-antigens, autoreactive T cells are readily detectable in the normal T-cell repertoire. In recent years, a population of CD4+ T cells that constitutively express the interleukin-2 receptor- chain, CD25, has been shown to play a pivotal role in the maintenance of self-tolerance in rodent models. This study investigated whether such a regulatory population exists in humans. A population of CD4+CD25+ T cells, taken from the peripheral blood of healthy individuals and phenotypically distinct from recently activated CD4+ T cells, was characterized. These cells were hyporesponsive to conventional T-cell stimuli and capable of suppressing the responses of CD4+CD25 T cells in vitro. Addition of exogenous interleukin-2 abrogated the hyporesponsiveness and suppressive effects of CD4+CD25+ cells. Suppression required cell-to-cell contact but did not appear to be via the inhibition of antigen-presenting cells. In addition, there were marked changes in the expression of Notch pathway molecules and their downstream signaling products at the transcriptional level, specifically in CD4+CD25+ cells, suggesting that this family of molecules plays a role in the regulatory function of CD4+CD25+ cells. Cells with similar phenotype and function were detected in umbilical venous blood from healthy newborn infants. These results suggest that CD4+CD25+ cells represent a population of regulatory T cells that arise during fetal life. Comparison with rodent CD4+CD25+ cells suggests that this population may play a key role in the prevention of autoimmune diseases in humans. © 2001 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. S. McGee, J. H. Edwan, and D. K. Agrawal Flt3-L Increases CD4+CD25+Foxp3+ICOS+ Cells in the Lungs of Cockroach-Sensitized and -Challenged Mice Am. J. Respir. Cell Mol. Biol., March 1, 2010; 42(3): 331 - 340. [Abstract] [Full Text] [PDF] C. Mobs, C. Slotosch, H. Loffler, T. Jakob, M. Hertl, and W. Pfutzner Birch Pollen Immunotherapy Leads to Differential Induction of Regulatory T Cells and Delayed Helper T Cell Immune Deviation J. Immunol., February 15, 2010; 184(4): 2194 - 2203. [Abstract] [Full Text] [PDF] D. Pozo, P. Anderson, and E. Gonzalez-Rey Induction of Alloantigen-Specific Human T Regulatory Cells by Vasoactive Intestinal Peptide J. 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[Abstract] [Full Text] [PDF] S. Barath, M. Aleksza, T. Tarr, S. Sipka, G. Szegedi, and E. Kiss Measurement of natural (CD4+CD25high) and inducible (CD4+IL-10+) regulatory T cells in patients with systemic lupus erythematosus Lupus, July 1, 2007; 16(7): 489 - 496. [Abstract] [PDF] J. Bayry, F. Triebel, S. V. Kaveri, and D. F. Tough Human Dendritic Cells Acquire a Semimature Phenotype and Lymph Node Homing Potential through Interaction with CD4+CD25+ Regulatory T Cells J. Immunol., April 1, 2007; 178(7): 4184 - 4193. [Abstract] [Full Text] [PDF] S. A. Siddiqui, X. Frigola, S. Bonne-Annee, M. Mercader, S. M. Kuntz, A. E. Krambeck, S. Sengupta, H. Dong, J. C. Cheville, C. M. Lohse, et al. Tumor-Infiltrating Foxp3-CD4+CD25+ T Cells Predict Poor Survival in Renal Cell Carcinoma Clin. Cancer Res., April 1, 2007; 13(7): 2075 - 2081. [Abstract] [Full Text] [PDF] M. I. Garin, C.-C. Chu, D. Golshayan, E. Cernuda-Morollon, R. Wait, and R. I. 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Classen, and J. L. Schultze In vivo peripheral expansion of naive CD4+CD25high FoxP3+ regulatory T cells in patients with multiple myeloma Blood, May 15, 2006; 107(10): 3940 - 3949. [Abstract] [Full Text] [PDF] D.-M. Zhao, A. M. Thornton, R. J. DiPaolo, and E. M. Shevach Activated CD4+CD25+ T cells selectively kill B lymphocytes Blood, May 15, 2006; 107(10): 3925 - 3932. [Abstract] [Full Text] [PDF] R. Houot, I. Perrot, E. Garcia, I. Durand, and S. Lebecque Human CD4+CD25high Regulatory T Cells Modulate Myeloid but Not Plasmacytoid Dendritic Cells Activation J. Immunol., May 1, 2006; 176(9): 5293 - 5298. [Abstract] [Full Text] [PDF] M. S. Longhi, M. J. Hussain, R. R. Mitry, S. K. Arora, G. Mieli-Vergani, D. Vergani, and Y. Ma Functional Study of CD4+CD25+ Regulatory T Cells in Health and Autoimmune Hepatitis J. Immunol., April 1, 2006; 176(7): 4484 - 4491. [Abstract] [Full Text] [PDF] C. K. Asiedu, K. J. Goodwin, G. Balgansuren, S. M. Jenkins, S. Le Bas-Bernardet, U. Jargal, D. M. Neville Jr, and J. M. Thomas Elevated T Regulatory Cells in Long-Term Stable Transplant Tolerance in Rhesus Macaques Induced by Anti-CD3 Immunotoxin and Deoxyspergualin J. Immunol., December 15, 2005; 175(12): 8060 - 8068. [Abstract] [Full Text] [PDF] M. Miyara, Z. Amoura, C. Parizot, C. Badoual, K. Dorgham, S. Trad, D. Nochy, P. Debre, J.-C. Piette, and G. Gorochov Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus J. Immunol., December 15, 2005; 175(12): 8392 - 8400. [Abstract] [Full Text] [PDF] M. Beyer, M. Kochanek, K. Darabi, A. Popov, M. Jensen, E. Endl, P. A. Knolle, R. K. Thomas, M. von Bergwelt-Baildon, S. Debey, et al. Reduced frequencies and suppressive function of CD4+CD25hi regulatory T cells in patients with chronic lymphocytic leukemia after therapy with fludarabine Blood, September 15, 2005; 106(6): 2018 - 2025. [Abstract] [Full Text] [PDF] M. J. Robertson, H.-C. Chang, D. Pelloso, and M. H. Kaplan Impaired interferon-{gamma} production as a consequence of STAT4 deficiency after autologous hematopoietic stem cell transplantation for lymphoma Blood, August 1, 2005; 106(3): 963 - 970. [Abstract] [Full Text] [PDF] T. Boettler, H. C. Spangenberg, C. Neumann-Haefelin, E. Panther, S. Urbani, C. Ferrari, H. E. Blum, F. von Weizsacker, and R. Thimme T Cells with a CD4+CD25+ Regulatory Phenotype Suppress In Vitro Proliferation of Virus-Specific CD8+ T Cells during Chronic Hepatitis C Virus Infection J. Virol., June 15, 2005; 79(12): 7860 - 7867. [Abstract] [Full Text] [PDF] H. J. P. M. Koenen, E. Fasse, and I. Joosten CD27/CFSE-Based Ex Vivo Selection of Highly Suppressive Alloantigen-Specific Human Regulatory T Cells J. Immunol., June 15, 2005; 174(12): 7573 - 7583. [Abstract] [Full Text] [PDF] G. Darrasse-Jeze, G. Marodon, B. L. Salomon, M. Catala, and D. Klatzmann Ontogeny of CD4+CD25+ regulatory/suppressor T cells in human fetuses Blood, June 15, 2005; 105(12): 4715 - 4721. [Abstract] [Full Text] [PDF] T. M. Brusko, C. H. Wasserfall, M. J. Clare-Salzler, D. A. Schatz, and M. A. Atkinson Functional Defects and the Influence of Age on the Frequency of CD4+CD25+ T-Cells in Type 1 Diabetes Diabetes, May 1, 2005; 54(5): 1407 - 1414. [Abstract] [Full Text] [PDF] T. M. Brusko, C. H. Wasserfall, A. Agarwal, M. H. Kapturczak, and M. A. Atkinson An Integral Role for Heme Oxygenase-1 and Carbon Monoxide in Maintaining Peripheral Tolerance by CD4+CD25+ Regulatory T Cells J. Immunol., May 1, 2005; 174(9): 5181 - 5186. [Abstract] [Full Text] [PDF] T. Bonnefoix, P. Bonnefoix, P. Perron, J.-Q. Mi, W. F. Ng, R. Lechler, J.-C. Bensa, J.-Y. Cahn, and D. Leroux Quantitating Effector and Regulatory T Lymphocytes in Immune Responses by Limiting Dilution Analysis Modeling J. Immunol., March 15, 2005; 174(6): 3421 - 3431. [Abstract] [Full Text] [PDF] M. R. Walker, B. D. Carson, G. T. Nepom, S. F. Ziegler, and J. H. Buckner De novo generation of antigen-specific CD4+CD25+ regulatory T cells from human CD4+CD25- cells PNAS, March 15, 2005; 102(11): 4103 - 4108. [Abstract] [Full Text] [PDF] C. Y. Liu, M. Battaglia, S. H. Lee, Q.-H. Sun, R. H. Aster, and G. P. Visentin Platelet Factor 4 Differentially Modulates CD4+CD25+ (Regulatory) versus CD4+CD25- (Nonregulatory) T Cells J. Immunol., March 1, 2005; 174(5): 2680 - 2686. [Abstract] [Full Text] [PDF] S. Storck, F. Delbos, N. Stadler, C. Thirion-Delalande, F. Bernex, C. Verthuy, P. Ferrier, J.-C. Weill, and C.-A. Reynaud Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain Mol. Cell. Biol., February 15, 2005; 25(4): 1437 - 1445. [Abstract] [Full Text] [PDF] B. Mommaas, J. A. Stegehuis-Kamp, A. G. van Halteren, M. Kester, J. Enczmann, P. Wernet, G. Kogler, T. Mutis, A. Brand, and E. Goulmy Cord blood comprises antigen-experienced T cells specific for maternal minor histocompatibility antigen HA-1 Blood, February 15, 2005; 105(4): 1823 - 1827. [Abstract] [Full Text] [PDF] P. E. Rao, A. L. Petrone, and P. D. Ponath Differentiation and Expansion of T Cells with Regulatory Function from Human Peripheral Lymphocytes by Stimulation in the Presence of TGF-{beta} J. Immunol., February 1, 2005; 174(3): 1446 - 1455. [Abstract] [Full Text] [PDF] A. Balandina, S. Lecart, P. Dartevelle, A. Saoudi, and S. Berrih-Aknin Functional defect of regulatory CD4+CD25+ T cells in the thymus of patients with autoimmune myasthenia gravis Blood, January 15, 2005; 105(2): 735 - 741. [Abstract] [Full Text] [PDF] W. R. Godfrey, D. J. Spoden, Y. G. Ge, S. R. Baker, B. Liu, B. L. Levine, C. H. June, B. R. Blazar, and S. B. Porter Cord blood CD4+CD25+-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function Blood, January 15, 2005; 105(2): 750 - 758. [Abstract] [Full Text] [PDF] S. Lindley, C. M. Dayan, A. Bishop, B. O. Roep, M. Peakman, and T. I.M. Tree Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes Diabetes, January 1, 2005; 54(1): 92 - 99. [Abstract] [Full Text] [PDF] E. A. Moseman, X. Liang, A. J. Dawson, A. Panoskaltsis-Mortari, A. M. Krieg, Y.-J. Liu, B. R. Blazar, and W. Chen Human Plasmacytoid Dendritic Cells Activated by CpG Oligodeoxynucleotides Induce the Generation of CD4+CD25+ Regulatory T Cells J. Immunol., October 1, 2004; 173(7): 4433 - 4442. [Abstract] [Full Text] [PDF] C. A. Thornton, J. W. Upham, M. E. Wikstrom, B. J. Holt, G. P. White, M. J. Sharp, P. D. Sly, and P. G. Holt Functional Maturation of CD4+CD25+CTLA4+CD45RA+ T Regulatory Cells in Human Neonatal T Cell Responses to Environmental Antigens/Allergens J. Immunol., September 1, 2004; 173(5): 3084 - 3092. [Abstract] [Full Text] [PDF] D S Robinson Regulation: the art of control? Regulatory T cells and asthma and allergy Thorax, August 1, 2004; 59(8): 640 - 643. [Full Text] [PDF] M. Viguier, F. Lemaitre, O. Verola, M.-S. Cho, G. Gorochov, L. Dubertret, H. Bachelez, P. Kourilsky, and L. Ferradini Foxp3 Expressing CD4+CD25high Regulatory T Cells Are Overrepresented in Human Metastatic Melanoma Lymph Nodes and Inhibit the Function of Infiltrating T Cells J. Immunol., July 15, 2004; 173(2): 1444 - 1453. [Abstract] [Full Text] [PDF] W. R. Godfrey, Y. G. Ge, D. J. Spoden, B. L. Levine, C. H. June, B. R. Blazar, and S. B. Porter In vitro-expanded human CD4+CD25+ T-regulatory cells can markedly inhibit allogeneic dendritic cell-stimulated MLR cultures Blood, July 15, 2004; 104(2): 453 - 461. [Abstract] [Full Text] [PDF] S. Vigouroux, E. Yvon, E. Biagi, and M. K. Brenner Antigen-induced regulatory T cells Blood, July 1, 2004; 104(1): 26 - 33. [Abstract] [Full Text] [PDF] M. R. Karlsson, J. Rugtveit, and P. Brandtzaeg Allergen-responsive CD4+CD25+ Regulatory T Cells in Children who Have Outgrown Cow's Milk Allergy J. Exp. Med., June 21, 2004; 199(12): 1679 - 1688. [Abstract] [Full Text] [PDF] A. Fietta, F. Meloni, M. Stanzani, and K. V. Komanduri Only genuine CD4+CD25+ Tregs may be friends or foes Blood, June 1, 2004; 103(11): 4369 - 4370. [Full Text] [PDF] K. A. Kasow, X. Chen, J. Knowles, D. Wichlan, R. Handgretinger, and J. M. Riberdy Human CD4+CD25+ Regulatory T Cells Share Equally Complex and Comparable Repertoires with CD4+CD25- Counterparts J. Immunol., May 15, 2004; 172(10): 6123 - 6128. [Abstract] [Full Text] [PDF] I. M. de Kleer, L. R. Wedderburn, L. S. Taams, A. Patel, H. Varsani, M. Klein, W. de Jager, G. Pugayung, F. Giannoni, G. Rijkers, et al. CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis J. Immunol., May 15, 2004; 172(10): 6435 - 6443. [Abstract] [Full Text] [PDF] J. LeMaoult, I. Krawice-Radanne, J. Dausset, and E. D. Carosella HLA-G1-expressing antigen-presenting cells induce immunosuppressive CD4+ T cells PNAS, May 4, 2004; 101(18): 7064 - 7069. [Abstract] [Full Text] [PDF] Y. Sasaki, M. Sakai, S. Miyazaki, S. Higuma, A. Shiozaki, and S. Saito Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases Mol. Hum. Reprod., May 1, 2004; 10(5): 347 - 353. [Abstract] [Full Text] [PDF] O. Boyer, D. Saadoun, J. Abriol, M. Dodille, J.-C. Piette, P. Cacoub, and D. Klatzmann CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis Blood, May 1, 2004; 103(9): 3428 - 3430. [Abstract] [Full Text] [PDF] N. Misra, J. Bayry, S. Lacroix-Desmazes, M. D. Kazatchkine, and S. V. Kaveri Cutting Edge: Human CD4+CD25+ T Cells Restrain the Maturation and Antigen-Presenting Function of Dendritic Cells J. Immunol., April 15, 2004; 172(8): 4676 - 4680. [Abstract] [Full Text] [PDF] F. J. Clark, R. Gregg, K. Piper, D. Dunnion, L. Freeman, M. Griffiths, G. Begum, P. Mahendra, C. Craddock, P. Moss, et al. Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells Blood, March 15, 2004; 103(6): 2410 - 2416. [Abstract] [Full Text] [PDF] E. M. Aandahl, J. Michaelsson, W. J. Moretto, F. M. Hecht, and D. F. Nixon Human CD4+ CD25+ Regulatory T Cells Control T-Cell Responses to Human Immunodeficiency Virus and Cytomegalovirus Antigens J. Virol., March 1, 2004; 78(5): 2454 - 2459. [Abstract] [Full Text] [PDF] L. A. Stephens, A. N. Barclay, and D. Mason Phenotypic characterization of regulatory CD4+CD25+ T cells in rats Int. Immunol., February 1, 2004; 16(2): 365 - 375. [Abstract] [Full Text] [PDF] M. Stanzani, S. L. R. Martins, R. M. Saliba, L. S. St. John, S. Bryan, D. Couriel, J. McMannis, R. E. Champlin, J. J. Molldrem, and K. V. Komanduri CD25 expression on donor CD4+ or CD8+ T cells is associated with an increased risk for graft-versus-host disease after HLA-identical stem cell transplantation in humans Blood, February 1, 2004; 103(3): 1140 - 1146. [Abstract] [Full Text] [PDF] H. Jonuleit and E. Schmitt The Regulatory T Cell Family: Distinct Subsets and their Interrelations J. Immunol., December 15, 2003; 171(12): 6323 - 6327. [Full Text] [PDF] H. J. P. M. Koenen, E. Fasse, and I. Joosten IL-15 and Cognate Antigen Successfully Expand De Novo-Induced Human Antigen-Specific Regulatory CD4+ T Cells That Require Antigen-Specific Activation for Suppression J. Immunol., December 15, 2003; 171(12): 6431 - 6441. [Abstract] [Full Text] [PDF] G. F. Hoyne Notch signaling in the immune system J. Leukoc. Biol., December 1, 2003; 74(6): 971 - 981. [Abstract] [Full Text] T. Keler, E. Halk, L. Vitale, T. O'Neill, D. Blanset, S. Lee, M. Srinivasan, R. F. Graziano, T. Davis, N. Lonberg, et al. Activity and Safety of CTLA-4 Blockade Combined with Vaccines in Cynomolgus Macaques J. Immunol., December 1, 2003; 171(11): 6251 - 6259. [Abstract] [Full Text] [PDF] A. Foussat, F. Cottrez, V. Brun, N. Fournier, J.-P. Breittmayer, and H. Groux A Comparative Study between T Regulatory Type 1 and CD4+CD25+ T Cells in the Control of Inflammation J. Immunol., November 15, 2003; 171(10): 5018 - 5026. [Abstract] [Full Text] [PDF] E. S. Yvon, S. Vigouroux, R. F. Rousseau, E. Biagi, P. Amrolia, G. Dotti, H.-J. Wagner, and M. K. Brenner Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells Blood, November 15, 2003; 102(10): 3815 - 3821. [Abstract] [Full Text] [PDF] E. Anastasi, A. F. Campese, D. Bellavia, A. Bulotta, A. Balestri, M. Pascucci, S. Checquolo, R. Gradini, U. Lendahl, L. Frati, et al. Expression of Activated Notch3 in Transgenic Mice Enhances Generation of T Regulatory Cells and Protects against Experimental Autoimmune Diabetes J. Immunol., November 1, 2003; 171(9): 4504 - 4511. [Abstract] [Full Text] [PDF] S. Vigouroux, E. Yvon, H.-J. Wagner, E. Biagi, G. Dotti, U. Sili, C. Lira, C. M. Rooney, and M. K. Brenner Induction of Antigen-Specific Regulatory T Cells following Overexpression of a Notch Ligand by Human B Lymphocytes J. Virol., October 15, 2003; 77(20): 10872 - 10880. [Abstract] [Full Text] [PDF] S. Jiang, N. Camara, G. Lombardi, and R. I. Lechler Induction of allopeptide-specific human CD4+CD25+ regulatory T cells ex vivo Blood, September 15, 2003; 102(6): 2180 - 2186. [Abstract] [Full Text] [PDF] N. Ardjomand, J. C. McAlister, N. J. Rogers, P. H. Tan, A. J. T. George, and D. F. P. Larkin Modulation of Costimulation by CD28 and CD154 Alters the Kinetics and Cellular Characteristics of Corneal Allograft Rejection Invest. Ophthalmol. Vis. Sci., September 1, 2003; 44(9): 3899 - 3905. [Abstract] [Full Text] [PDF] T. Azuma, T. Takahashi, A. Kunisato, T. Kitamura, and H. Hirai Human CD4+ CD25+ Regulatory T Cells Suppress NKT Cell Functions Cancer Res., August 1, 2003; 63(15): 4516 - 4520. [Abstract] [Full Text] [PDF] A. Hug, M. Korporal, I. Schroder, J. Haas, K. Glatz, B. Storch-Hagenlocher, and B. Wildemann Thymic Export Function and T Cell Homeostasis in Patients with Relapsing Remitting Multiple Sclerosis J. Immunol., July 1, 2003; 171(1): 432 - 437. [Abstract] [Full Text] [PDF] C. P. Gray, P. Arosio, and P. Hersey Association of Increased Levels of Heavy-Chain Ferritin with Increased CD4+ CD25+ Regulatory T-Cell Levels in Patients with Melanoma Clin. Cancer Res., July 1, 2003; 9(7): 2551 - 2559. [Abstract] [Full Text] [PDF] C. Pridgeon, G. P. Lennon, L. Pazmany, R. N. Thompson, S. E. Christmas, and R. J. Moots Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright,CD94bright,CD158negative phenotype Rheumatology, July 1, 2003; 42(7): 870 - 878. [Abstract] [Full Text] [PDF] A. D. Salama, N. Najafian, M. R. Clarkson, W. E. Harmon, and M. H. Sayegh Regulatory CD25+ T Cells in Human Kidney Transplant Recipients J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1643 - 1651. [Abstract] [Full Text] [PDF] D. S. Game, M. P. Hernandez-Fuentes, A. N. Chaudhry, and R. I. Lechler CD4+CD25+ Regulatory T Cells Do Not Significantly Contribute to Direct Pathway Hyporesponsiveness in Stable Renal Transplant Patients J. Am. Soc. Nephrol., June 1, 2003; 14(6): 1652 - 1661. [Abstract] [Full Text] [PDF] A. Lundgren, E. Suri-Payer, K. Enarsson, A.-M. Svennerholm, and B. S. Lundin Helicobacterpylori-Specific CD4+ CD25high Regulatory T Cells Suppress Memory T-Cell Responses to H. pylori in Infected Individuals Infect. Immun., April 1, 2003; 71(4): 1755 - 1762. [Abstract] [Full Text] [PDF] A. M. Wolf, D. Wolf, M. Steurer, G. Gastl, E. Gunsilius, and B. Grubeck-Loebenstein Increase of Regulatory T Cells in the Peripheral Blood of Cancer Patients Clin. Cancer Res., February 1, 2003; 9(2): 606 - 612. [Abstract] [Full Text] [PDF] W. F. Ng, M. Hernandez-Fuentes, R. Baker, A. Chaudhry, and R. I. Lechler Reversibility with Interleukin-2 Suggests that T Cell Anergy Contributes to Donor-Specific Hyporesponsiveness in Renal Transplant Patients J. Am. Soc. Nephrol., December 1, 2002; 13(12): 2983 - 2989. [Abstract] [Full Text] [PDF] M. K. Levings, R. Sangregorio, C. Sartirana, A. L. Moschin, M. Battaglia, P. C. Orban, and M.-G. Roncarolo Human CD25+CD4+ T Suppressor Cell Clones Produce Transforming Growth Factor {beta}, but not Interleukin 10, and Are Distinct from Type 1 T Regulatory Cells J. Exp. Med., November 18, 2002; 196(10): 1335 - 1346. [Abstract] [Full Text] [PDF] K. Namba, N. Kitaichi, T. Nishida, and A. W. Taylor Induction of regulatory T cells by the immunomodulating cytokines {alpha}-melanocyte-stimulating hormone and transforming growth factor-{beta}2 J. Leukoc. Biol., November 1, 2002; 72(5): 946 - 952. [Abstract] [Full Text] [PDF] F. Annunziato, L. Cosmi, F. Liotta, E. Lazzeri, R. Manetti, V. Vanini, P. Romagnani, E. Maggi, and S. Romagnani Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes J. Exp. Med., August 5, 2002; 196(3): 379 - 387. [Abstract] [Full Text] [PDF] P. Hoffmann, J. Ermann, M. Edinger, C. G. Fathman, and S. Strober Donor-type CD4+CD25+ Regulatory T Cells Suppress Lethal Acute Graft-Versus-Host Disease after Allogeneic Bone Marrow Transplantation J. Exp. Med., August 5, 2002; 196(3): 389 - 399. [Abstract] [Full Text] [PDF] C. A. Piccirillo, J. J. Letterio, A. M. Thornton, R. S. McHugh, M. Mamura, H. Mizuhara, and E. M. Shevach CD4+CD25+ Regulatory T Cells Can Mediate Suppressor Function in the Absence of Transforming Growth Factor {beta}1 Production and Responsiveness J. Exp. Med., July 15, 2002; 196(2): 237 - 246. [Abstract] [Full Text] [PDF] D. Dieckmann, C. H. Bruett, H. Ploettner, M. B. Lutz, and G. Schuler Human CD4+CD25+ Regulatory, Contact-dependent T Cells Induce Interleukin 10-producing, Contact-independent Type 1-like Regulatory T Cells J. Exp. Med., July 15, 2002; 196(2): 247 - 253. [Abstract] [Full Text] [PDF] H. Jonuleit, E. Schmitt, H. Kakirman, M. Stassen, J. Knop, and A. H. Enk Infectious Tolerance: Human CD25+ Regulatory T Cells Convey Suppressor Activity to Conventional CD4+ T Helper Cells J. Exp. Med., July 15, 2002; 196(2): 255 - 260. [Abstract] [Full Text] [PDF] M. Guimond, A. Balassy, M. Barrette, S. Brochu, C. Perreault, and D. C. Roy P-glycoprotein targeting: a unique strategy to selectively eliminate immunoreactive T cells Blood, June 28, 2002; 100(2): 375 - 382. [Abstract] [Full Text] [PDF] R. M. Steinman and M. C. Nussenzweig Inaugural Article: Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance PNAS, January 8, 2002; 99(1): 351 - 358. [Abstract] [Full Text] [PDF]

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