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Blood, 1 January 2002, Vol. 99, No. 1, pp. 336-341
PHAGOCYTES
Control of leukocyte rolling velocity in TNF- -induced
inflammation by LFA-1 and Mac-1
Jessica L. Dunne,
Christie
M. Ballantyne,
Arthur L. Beaudet, and
Klaus Ley
From the Department of Biomedical Engineering and
Cardiovascular Research Center, University of Virginia Health Sciences
Center, Charlottesville, VA; and the Departments of Medicine and
Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Previously it was shown that  2-integrins are
necessary for slow leukocyte rolling in inflamed venules. In this
study, mice that are deficient for either one of the
2-integrins,  L2 (LFA-1) or
M2 (Mac-1), were used to determine which
of the 2-integrins are responsible for slowing rolling
leukocytes. The cremaster muscles of these mice were treated with tumor
necrosis factor- and prepared for intravital microscopy. The average
rolling velocities in venules were elevated in LFA-1 /
mice (11.0 ± 0.7 µm/s) and Mac-1/ mice
(10.1 ± 1.1 µm/s) compared to wild-type mice (4.8 ± 0.3 µm/s;
P < .05), but were lower than in CD18/
mice (28.5 ± 2.1 µm/s). When both LFA-1 and Mac-1 were absent or
blocked, rolling velocity became dependent on shear rate and approached
that of CD18/ mice. In addition, leukocyte adhesion
efficiency was decreased in LFA-1/ mice to near
CD18/ levels, but decreased only slightly in
Mac-1/ mice. Thus, both LFA-1 and Mac-1 contribute to
slowing down rolling leukocytes, although LFA-1 is more important than
Mac-1 in efficiently inducing firm adhesion.
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