|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 May 2002, Vol. 99, No. 10, pp. 3676-3682
IMMUNOBIOLOGY
Human platelets express heat shock protein receptors and regulate
dendritic cell maturation
Norbert Hilf,
Harpreet Singh-Jasuja,
Petra Schwarzmaier,
Cécile Gouttefangeas,
Hans-Georg Rammensee, and
Hansjörg Schild
From the Department of Immunology, University of
Tübingen, Germany.
Immunizations using the endoplasmic reticulum-resident heat shock
protein Gp96 induce specific immune responses. Specificity is based on
the major histocompatibility complex class I-restricted cross-presentation of Gp96-associated peptides derived from endogenous proteins. Initiation of the immune response depends on the ability of
Gp96 to induce the production of proinflammatory cytokines by
macrophages and dendritic cells (DCs) and of their maturation in a
fashion presumably independent of associated peptide. Both events are
mediated by Gp96 receptors on antigen-presenting cells. It is known
that Gp96 is released from cells at necrosis induced, for example, by
virus infection. Although this event supports the efficient induction
of immune responses, it might also interfere with processes that are
susceptible to chronic inflammation, such as wound healing after tissue
damage. Therefore, Gp96-mediated stimulation of the immune system
requires tight regulation. Here we show that human thrombocytes
specifically interact with Gp96 and that binding of Gp96 to platelets
is enhanced more than 10-fold on activation by thrombin. Gp96
interferes with neither thrombin-induced platelet activation nor
platelet aggregation. However, the presence of platelets during
Gp96-mediated DC activation reduces the secretion of proinflammatory
cytokines and the activation of DCs. This effect is independent of
soluble platelet factors and cell-to-cell contact between DCs and
thrombocytes. Thus, we provide evidence for a regulatory mechanism that
neutralizes Gp96 molecules systemically, especially in the blood. This
effect might be of significance in wounds in which chronic inflammation
and immune responses against autoantigens have to be prevented.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
Q.-Q. Huang, R. Sobkoviak, A. R. Jockheck-Clark, B. Shi, A. M. Mandelin II, P. P. Tak, G. K. Haines III, C. V. Nicchitta, and R. M. Pope
Heat Shock Protein 96 Is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily via TLR2 Signaling
J. Immunol.,
April 15, 2009;
182(8):
4965 - 4973.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. A. Bozza, A. M. Shah, A. S. Weyrich, and G. A. Zimmerman
Amicus or Adversary: Platelets in Lung Biology, Acute Injury, and Inflammation
Am. J. Respir. Cell Mol. Biol.,
February 1, 2009;
40(2):
123 - 134.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. De Filippo, R. J. Binder, C. Camisaschi, V. Beretta, F. Arienti, A. Villa, P. Della Mina, G. Parmiani, L. Rivoltini, and C. Castelli
Human Plasmacytoid Dendritic Cells Interact with gp96 via CD91 and Regulate Inflammatory Responses
J. Immunol.,
November 1, 2008;
181(9):
6525 - 6535.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. D. Elzey, N. W. Schmidt, S. A. Crist, T. P. Kresowik, J. T. Harty, B. Nieswandt, and T. L. Ratliff
Platelet-derived CD154 enables T-cell priming and protection against Listeria monocytogenes challenge
Blood,
April 1, 2008;
111(7):
3684 - 3691.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Han, S. G. Park, B. Liu, B.-J. Park, J. Y. Kim, C. H. Jin, Y. W. Song, Z. Li, and S. Kim
Aminoacyl-tRNA Synthetase-Interacting Multifunctional Protein 1/p43 Controls Endoplasmic Reticulum Retention of Heat Shock Protein gp96: Its Pathological Implications in Lupus-Like Autoimmune Diseases
Am. J. Pathol.,
June 1, 2007;
170(6):
2042 - 2054.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pilla, P. Squarcina, J. Coppa, V. Mazzaferro, V. Huber, D. Pende, C. Maccalli, G. Sovena, L. Mariani, C. Castelli, et al.
Natural Killer and NK-Like T-Cell Activation in Colorectal Carcinoma Patients Treated with Autologous Tumor-Derived Heat Shock Protein 96
Cancer Res.,
May 1, 2005;
65(9):
3942 - 3949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. SenGupta, P. J. Norris, T. J. Suscovich, M. Hassan-Zahraee, H. F. Moffett, A. Trocha, R. Draenert, P. J. R. Goulder, R. J. Binder, D. L. Levey, et al.
Heat Shock Protein-Mediated Cross-Presentation of Exogenous HIV Antigen on HLA Class I and Class II
J. Immunol.,
August 1, 2004;
173(3):
1987 - 1993.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Hagihara, A. Higuchi, N. Tamura, Y. Ueda, K. Hirabayashi, Y. Ikeda, S. Kato, S. Sakamoto, T. Hotta, S. Handa, et al.
Platelets, after Exposure to a High Shear Stress, Induce IL-10-Producing, Mature Dendritic Cells In Vitro
J. Immunol.,
May 1, 2004;
172(9):
5297 - 5303.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Y. Chandawarkar, M. S. Wagh, J. T. Kovalchin, and P. Srivastava
Immune modulation with high-dose heat-shock protein gp96: therapy of murine autoimmune diabetes and encephalomyelitis
Int. Immunol.,
April 1, 2004;
16(4):
615 - 624.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. McRedmond, S. D. Park, D. F. Reilly, J. A. Coppinger, P. B. Maguire, D. C. Shields, and D. J. Fitzgerald
Integration of Proteomics and Genomics in Platelets: A PROFILE OF PLATELET PROTEINS AND PLATELET-SPECIFIC GENES
Mol. Cell. Proteomics,
February 1, 2004;
3(2):
133 - 144.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Walter, L. Herrgen, O. Schoor, G. Jung, D. Wernet, H.-J. Buhring, H.-G. Rammensee, and S. Stevanovic
Cutting Edge: Predetermined Avidity of Human CD8 T Cells Expanded on Calibrated MHC/Anti-CD28-Coated Microspheres
J. Immunol.,
November 15, 2003;
171(10):
4974 - 4978.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. P. Radsak, N. Hilf, H. Singh-Jasuja, S. Braedel, P. Brossart, H.-G. Rammensee, and H. Schild
The heat shock protein Gp96 binds to human neutrophils and monocytes and stimulates effector functions
Blood,
April 1, 2003;
101(7):
2810 - 2815.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
