|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 May 2002, Vol. 99, No. 10, pp. 3806-3812
NEOPLASIA
Cytomorphologic, immunohistochemical, and cytogenetic profiles of
follicular lymphoma: 2 types of follicular lymphoma grade 3
German Ott,
Tiemo Katzenberger,
Andreas Lohr,
Steffi Kindelberger,
Thomas Rüdiger,
Martin Wilhelm,
Jörg Kalla,
Andreas Rosenwald,
Justus G. Müller,
M. Michaela Ott, and
Hans Konrad Müller-Hermelink
From the Pathologisches Institut and Poliklinik
für Innere Medizin, University of Würzburg,
Germany.
Follicular lymphoma (FL) grades 1 and 2 are regarded as a distinct
disease entity, whereas data suggest that FL grade 3 might be an
inhomogeneous tumor category. To define the biologic spectrum of FL, 89 follicular lymphomas were studied for their cytologic composition,
antigen expression, mitotic and proliferation indices, cytogenetics,
and clinical data. In contrast to the homogeneous appearance of FL
grades 1 and 2 (29 and 33 cases, respectively), 2 types of FL grade 3 were recognized. Eleven cases of FL 3a displayed structural features
similar to those of FL 1 and 2 and were composed of centroblasts and
centrocytes, whereas 16 cases of FL 3b, with (n = 4) or without
(n = 12) a diffuse large B-cell lymphoma component (DLBL) (FL 3b ± DLBL), consisted exclusively of blasts. In contrast to FL 3a, FL
3b ± DLBL were CD10+ in only 50% of cases and
displayed plasmacytoid differentiation in 44% of cases. Although
FL3a was t(14;18)+ in 8 of 11 (73%) cases, only 2 of 16 (13%)
FL3b ± DLBLs harbored this translocation. In contrast,
chromosomal breaks at 3q27 were encountered in 7 of 16 (44%) FL
3b ± DLBL in contrast to only 2 of 11 (18%) FL 3a, and the
spectrum of secondary aberrations in FL 3b ± DLBL was similar to
that of diffuse large B-cell lymphoma. We conclude, therefore, that FL
grade 3 is a heterogeneous disease group and that the distinction
proposed in the new World Health Organization classification between FL
3a (with centrocytes) and FL3b (without centrocytes) is of biologic,
and possibly clinical, importance.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
T. Katzenberger, J. Kalla, E. Leich, H. Stocklein, E. Hartmann, S. Barnickel, S. Wessendorf, M. M. Ott, H. K. Muller-Hermelink, A. Rosenwald, et al.
A distinctive subtype of t(14;18)-negative nodal follicular non-Hodgkin lymphoma characterized by a predominantly diffuse growth pattern and deletions in the chromosomal region 1p36
Blood,
January 29, 2009;
113(5):
1053 - 1061.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Ott and A. Rosenwald
Molecular pathogenesis of follicular lymphoma
Haematologica,
December 1, 2008;
93(12):
1773 - 1776.
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Gagyi, Z. Balogh, C. Bodor, B. Timar, L. Reiniger, L. Deak, J. Csomor, B. Csernus, A. Szepesi, and A. Matolcsy
Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression
Haematologica,
December 1, 2008;
93(12):
1822 - 1828.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. S. Jaffe, N. L. Harris, H. Stein, and P. G. Isaacson
Classification of lymphoid neoplasms: the microscope as a tool for disease discovery
Blood,
December 1, 2008;
112(12):
4384 - 4399.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. A. Johnson and R. D. Gascoyne
Gene expression signatures in follicular lymphoma: are they ready for the clinic?
Haematologica,
July 1, 2008;
93(7):
982 - 987.
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. J. Overman, L. Feng, B. Pro, P. McLaughlin, M. Hess, F. Samaniego, A. Younes, J. E. Romaguera, F. B. Hagemeister, L. Kwak, et al.
The addition of rituximab to CHOP chemotherapy improves overall and failure-free survival for follicular grade 3 lymphoma
Ann. Onc.,
March 1, 2008;
19(3):
553 - 559.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. LeBrun, T. Baetz, C. Foster, P. Farmer, R. Sidhu, H. Guo, K. Harrison, R. Somogyi, L. D. Greller, and H. Feilotter
Predicting Outcome in Follicular Lymphoma by Using Interactive Gene Pairs
Clin. Cancer Res.,
January 15, 2008;
14(2):
478 - 487.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Prakash and S. H Swerdlow
Nodal aggressive B-cell lymphomas: a diagnostic approach
J. Clin. Pathol.,
October 1, 2007;
60(10):
1076 - 1085.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. K. Weinberg, W. Z. Ai, M. R. Mariappan, C. Shum, R. Levy, and D. A. Arber
''Minor'' BCL2 Breakpoints in Follicular Lymphoma: Frequency and Correlation with Grade and Disease Presentation in 236 Cases
J. Mol. Diagn.,
September 1, 2007;
9(4):
530 - 537.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Karube, Y. Guo, J. Suzumiya, Y. Sugita, Y. Nomura, K. Yamamoto, K. Shimizu, S. Yoshida, H. Komatani, M. Takeshita, et al.
CD10-MUM1+ follicular lymphoma lacks BCL2 gene translocation and shows characteristic biologic and clinical features
Blood,
April 1, 2007;
109(7):
3076 - 3079.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. E. Wahlin, B. Sander, B. Christensson, and E. Kimby
CD8+ T-Cell Content in Diagnostic Lymph Nodes Measured by Flow Cytometry Is a Predictor of Survival in Follicular Lymphoma
Clin. Cancer Res.,
January 15, 2007;
13(2):
388 - 397.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Wohrer, U. Jaeger, K. Kletter, A. Becherer, A. Hauswirth, K. Turetschek, M. Raderer, and M. Hoffmann
18F-fluoro-deoxy-glucose positron emission tomography (18F-FDG-PET) visualizes follicular lymphoma irrespective of grading
Ann. Onc.,
May 1, 2006;
17(5):
780 - 784.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. H. Sehn
Optimal Use of Prognostic Factors in Non-Hodgkin Lymphoma
Hematology,
January 1, 2006;
2006(1):
295 - 302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Kobayashi, N. Murashige, Y. Kishi Jr., K. N. Naresh, T. F. Gajewski, S. S. Dave, and L. M. Staudt
Lymphoma-Infiltrating Immune Cells
N. Engl. J. Med.,
February 17, 2005;
352(7):
724 - 725.
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. D. Gascoyne
Hematopathology Approaches to Diagnosis and Prognosis of Indolent B-Cell Lymphomas
Hematology,
January 1, 2005;
2005(1):
299 - 306.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Katzenberger, G. Ott, T. Klein, J. Kalla, H. K. Muller-Hermelink, and M. M. Ott
Cytogenetic Alterations Affecting BCL6 Are Predominantly Found in Follicular Lymphomas Grade 3B with a Diffuse Large B-Cell Component
Am. J. Pathol.,
August 1, 2004;
165(2):
481 - 490.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. N. Winter, R. D. Gascoyne, and K. Van Besien
Low-Grade Lymphoma
Hematology,
January 1, 2004;
2004(1):
203 - 220.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Boudova, E. Torlakovic, J. Delabie, P. Reimer, B. Pfistner, S. Wiedenmann, V. Diehl, H.-K. Muller-Hermelink, and T. Rudiger
Nodular lymphocyte-predominant Hodgkin lymphoma with nodules resembling T-cell/histiocyte-rich B-cell lymphoma: differential diagnosis between nodular lymphocyte-predominant Hodgkin lymphoma and T-cell/histiocyte-rich B-cell lymphoma
Blood,
November 15, 2003;
102(10):
3753 - 3758.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. P. Hans, D. D. Weisenburger, J. M. Vose, L. M. Hock, J. C. Lynch, P. Aoun, T. C. Greiner, W. C. Chan, R. G. Bociek, P. J. Bierman, et al.
A significant diffuse component predicts for inferior survival in grade 3 follicular lymphoma, but cytologic subtypes do not predict survival
Blood,
March 15, 2003;
101(6):
2363 - 2367.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Bosga-Bouwer, G. W. van Imhoff, R. Boonstra, A. van der Veen, E. Haralambieva, A. van den Berg, B. de Jong, V. Krause, M. C. Palmer, R. Coupland, et al.
Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive
Blood,
February 1, 2003;
101(3):
1149 - 1154.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
