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Blood, 15 May 2002, Vol. 99, No. 10, pp. 3844-3847
BRIEF REPORT
Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte
cross-reactivity against prevalent HLA class I alleles
David M. Koelle,
Hongbo B. Chen,
Christopher M. McClurkan, and
Effie W. Petersdorf
From the Departments of Medicine, Laboratory Medicine,
and Pathobiology, University of Washington, Seattle; the Virginia Mason
Research Center, Seattle, WA; and the Fred Hutchinson Cancer Research
Center, Seattle, WA
Clonally expressed T-cell receptor   heterodimers are able to
bind many different major histocompatibility complex/peptide combinations. This promiscuity is thought to be required for adequate surveillance against microbial and malignancy-associated antigens. After transplantation, T cells may react with nonself structures, contributing to graft-versus-host disease, in the case of hematopoietic stem cell transplantation, or graft failure, when the host immune system is preserved. We describe 2 distinct HLA A*0201-restricted, cytotoxic CD8 T-cell responses to the prevalent chronic pathogen, herpes simplex virus type 2, that cross-react with cells bearing specific alleles of the common HLA B44 family. Transfection of human or
primate renal epithelial cells with HLA class I complementary DNA
confirmed these results. Given the prevalence of this viral infection
and the HLA alleles involved, it is possible that this cross-reactivity
may be involved in clinically significant events.
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