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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Egan, A. F. Articles by Miller, L. H. Search for Related Content PubMed PubMed Citation Articles by Egan, A. F. Articles by Miller, L. H. Related Collections Red Cells Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 May 2002, Vol. 99, No. 10, pp. 3863-3866 BRIEF REPORT Aotus New World monkeys: model for studying malaria-induced anemia Andrea F. Egan, Maria Elena Fabucci, Allan Saul, David C. Kaslow, and Louis H. Miller From the Malaria Vaccines Section and Malaria Vaccine Development Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD. Falciparum malaria is a major cause of disease and death in African children and pregnant women, primarily due to severe anemia. We studied anemia in vaccinated Aotus monkeys during a second infection where the animals were considered to be semi-immune. Most animals had extremely low or undetectable levels of parasitemia; in some, anemia did not develop and reticulocytemia remained unchanged; in others, moderate to severe anemia developed with inappropriately low reticulocytemia indicating bone marrow dysfunction. Bone marrow rapidly responded after parasite clearance. The rapid drop in hematocrit despite extremely low to undetectable parasitemia indicated massive removal of uninfected red blood cells from the circulation that, in the presence of bone marrow dysfunction, led to severe anemiathe problem that occurs in African children. We demonstrate that Aotus monkeys are a nonhuman primate model to gain insight into the pathogenesis of severe anemia in African children. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. W. Pawluczkowycz, M. A. Lindorfer, J. N. Waitumbi, and R. P. Taylor Hematin Promotes Complement Alternative Pathway-Mediated Deposition of C3 Activation Fragments on Human Erythrocytes: Potential Implications for the Pathogenesis of Anemia in Malaria J. Immunol., October 15, 2007; 179(8): 5543 - 5552. [Abstract] [Full Text] [PDF] N. Obaldia III Clinico-Pathological Observations on the Pathogenesis of Severe Thrombocytopenia and Anemia Induced by Plasmodium vivax Infections During Antimalarial Drug Efficacy Trials in Aotus Monkeys Am J Trop Med Hyg, July 1, 2007; 77(1): 3 - 13. [Abstract] [Full Text] [PDF] A. A. Lamikanra, D. Brown, A. Potocnik, C. Casals-Pascual, J. Langhorne, and D. J. Roberts Malarial anemia: of mice and men Blood, July 1, 2007; 110(1): 18 - 28. [Abstract] [Full Text] [PDF] A. MORENO, A. GARCIA, M. CABRERA-MORA, E. STROBERT, and M. R. GALINSKI DISSEMINATED INTRAVASCULAR COAGULATION COMPLICATED BY PERIPHERAL GANGRENE IN A RHESUS MACAQUE (MACACA MULATTA) EXPERIMENTALLY INFECTED WITH PLASMODIUM COATNEYI Am J Trop Med Hyg, April 1, 2007; 76(4): 648 - 654. [Abstract] [Full Text] [PDF] C. Casals-Pascual, O. Kai, J. O. P. Cheung, S. Williams, B. Lowe, M. Nyanoti, T. N. Williams, K. Maitland, M. Molyneux, C. R. J. C. Newton, et al. Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo Blood, October 15, 2006; 108(8): 2569 - 2577. [Abstract] [Full Text] [PDF] J. W. Barnwell Malaria: death and disappearing erythrocytes Blood, February 1, 2006; 107(3): 854 - 855. [Full Text] [PDF] K. J. Evans, D. S. Hansen, N. van Rooijen, L. A. Buckingham, and L. Schofield Severe malarial anemia of low parasite burden in rodent models results from accelerated clearance of uninfected erythrocytes Blood, February 1, 2006; 107(3): 1192 - 1199. [Abstract] [Full Text] [PDF] M. L. Craig, J. N. Waitumbi, and R. P. Taylor Processing of C3b-Opsonized Immune Complexes Bound to Non-Complement Receptor 1 (CR1) Sites on Red Cells: Phagocytosis, Transfer, and Associations with CR1 J. Immunol., March 1, 2005; 174(5): 3059 - 3066. [Abstract] [Full Text] [PDF] A. Dicko, A. D. Klion, M. A. Thera, I. Sagara, D. Yalcouye, M. B. Niambele, M. Sogoba, G. Dolo, A. Dao, D. A. Diallo, et al. The etiology of severe anemia in a village and a periurban area in Mali Blood, August 15, 2004; 104(4): 1198 - 1200. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020