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Blood, 1 June 2002, Vol. 99, No. 11, pp. 4216-4218
BRIEF REPORT
Relationship between glutathione S-transferase M1, T1, and P1
polymorphisms and chronic lymphocytic leukemia
Martin Yuille,
Alison Condie,
Chantelle Hudson,
Zsofia Kote-Jarai,
Elaine Stone,
Rosalind Eeles,
Estella Matutes,
Daniel Catovsky, and
Richard Houlston
From the Academic Department of Haematology and
Cytogenetics, and the Section of Cancer Genetics, Institute of Cancer
Research, Sutton, Surrey, United Kingdom.
Interindividual differences in susceptibility to hematologic
malignancies may be mediated in part through polymorphic variability in
the bioactivation and detoxification of carcinogens. The glutathione S-transferases (GSTs) have been implicated as susceptibility genes in
this context for a number of cancers. The aim of this study was to
examine whether polymorphic variation in GSTs confers susceptibility to
chronic lymphocytic leukemia (CLL). GSTM1, GSTT1, and
GSTP1 genotypes were determined in 138 patients and 280 healthy individuals. The frequency of both GSTM1 and
GSTT1 null genotypes and the GSTP1-Ile allele
was higher in cases than in controls. There was evidence of a trend in
increasing risk with the number of putative "high-risk" alleles of
the GST family carried (P = .04). The risk of CLL
associated with possession of all 3 "high-risk" genotypes was
increased 2.8-fold (OR = 2.8, 95% confidence interval: 1.1-6.9). Our
findings suggest that heritable GST status may influence the risk of
developing CLL.
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