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Blood, 1 June 2002, Vol. 99, No. 11, pp. 4228-4230
BRIEF REPORT
Measurement of spleen volume by ultrasound scanning in
patients with thrombocytosis: a prospective study
Marco Picardi,
Vincenzo Martinelli,
Rosanna Ciancia,
Ernesto Soscia,
Roberto Morante,
Antonio Sodano,
Giuliana Fortunato, and
Bruno Rotoli
From the Division of Hematology and Departments of
Infectious Diseases, Radiology and Laboratory Medicine, Federico II
University Medical School, Naples, Italy.
Spleen size was assessed in 73 patients with thrombocytosis and in
15 healthy subjects, comparing palpation with ultrasonography (US)
measurement of longitudinal diameter and volume. Intraobserver and
interobserver variability for volume on US, checked in 12 patients, was
very low. Correlation between spleen volume measured by US and that
measured by computed tomography was excellent. Splenomegaly was
detected by palpation in 25% of patients, by US assessment of
longitudinal diameter in 33%, and by US assessment of volume in 52%.
After diagnostic work-up, 54 patients had a diagnosis of essential
thrombocythemia (ET), 4 of idiopathic myelofibrosis (IMF), and
15 of secondary thrombocytosis (ST). Spleen volume in patients
with ST was in the normal range (138 ± 47 mL) and was significantly
lower than that in patients with ET or IMF (370 ± 210 mL;
P < .001). Thus, US-measured volume was the most
sensitive method for identifying nonpalpable splenomegaly in
patients with primary myeloproliferative diseases, and it may help in
distinguishing these diseases from reactive disorders.
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