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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Bagley, J. Articles by Iacomini, J. Search for Related Content PubMed PubMed Citation Articles by Bagley, J. Articles by Iacomini, J. Related Collections Gene Therapy Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 June 2002, Vol. 99, No. 12, pp. 4394-4399 GENE THERAPY Induction of T-cell tolerance to an MHC class I alloantigen by gene therapy Jessamyn Bagley, Chaorui Tian, David H. Sachs, and John Iacomini From the Transplantation Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA. Induction of immunologic tolerance to alloantigens is a major goal in the field of transplantation. Here, we demonstrate that efficient transduction and expression of a retrovirally transduced major histocompatibility complex (MHC) class I gene (H-2Kb) in bone marrow (BM)-derived cells, resulting in a permanent state of hematopoietic molecular chimerism, induces stable tolerance to the transduced gene product. Reconstitution of lethally irradiated syngeneic recipients with BM transduced with virus encoding H-2Kb resulted in life-long expression of the retroviral gene product on the surface of BM-derived hematopoietic lineages including Sca-1+, lineage negative, hematopoietic progenitors. T cells from mice receiving MHC-transduced BM were unable to kill targets expressing H-2Kb but were able to respond to third-party controls. Mice reconstituted with H-2Kb-transduced BM exhibited long-term acceptance of H-2Kb mismatched skin grafts but were able to rapidly reject third-party control grafts. Thus, gene therapy approaches may be used to induce T-cell tolerance. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Vassalli, M.-E. Roehrich, P. Vogt, G. B. Pedrazzini, F. Siclari, T. Moccetti, and L. K. von Segesser Modalities and future prospects of gene therapy in heart transplantation Eur. J. Cardiothorac. Surg., June 1, 2009; 35(6): 1036 - 1044. [Abstract] [Full Text] [PDF] J. Chan, E. J. Ban, K. H. Chun, S. Wang, B. T. Backstrom, C. C. A. Bernard, B.-H. Toh, and F. Alderuccio Transplantation of Bone Marrow Transduced to Express Self-Antigen Establishes Deletional Tolerance and Permanently Remits Autoimmune Disease J. Immunol., December 1, 2008; 181(11): 7571 - 7580. 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Brocker Transcriptional Targeting of B Cells for Induction of Peripheral CD8 T Cell Tolerance J. Immunol., June 15, 2007; 178(12): 7738 - 7746. [Abstract] [Full Text] [PDF] G. Marodon, S. Fisson, B. Levacher, M. Fabre, B. L. Salomon, and D. Klatzmann Induction of antigen-specific tolerance by intrathymic injection of lentiviral vectors Blood, November 1, 2006; 108(9): 2972 - 2978. [Abstract] [Full Text] [PDF] D. Forman, E.-S. Kang, C. Tian, J. Paez-Cortez, and J. Iacomini Induction of Alloreactive CD4 T Cell Tolerance in Molecular Chimeras: A Possible Role for Regulatory T Cells J. Immunol., March 15, 2006; 176(6): 3410 - 3416. [Abstract] [Full Text] [PDF] C. Tian, J. Bagley, D. Forman, and J. Iacomini Induction of Central Tolerance by Mature T Cells J. Immunol., December 15, 2004; 173(12): 7217 - 7222. [Abstract] [Full Text] [PDF] E. Dobrzynski, F. Mingozzi, Y.-L. Liu, E. Bendo, O. Cao, L. Wang, and R. W. 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	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020