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Blood, 15 January 2002, Vol. 99, No. 2, pp. 427-436
CHEMOKINES
Interleukin-10 modulates the sensitivity of peritoneal B
lymphocytes to chemokines with opposite effects on stromal
cell-derived factor-1 and B-lymphocyte chemoattractant
Karl Balabanian,
Arnaud Foussat,
Laurence Bouchet-Delbos,
Jacques Couderc,
Roman Krzysiek,
Ali Amara,
Françoise Baleux,
Alain Portier,
Pierre Galanaud, and
Dominique Emilie
From INSERM U131, Institut Paris-Sud sur les Cytokines,
Clamart, France; and Unité d'Immunologie Virale and Unité
de Chimie Organique, Institut Pasteur, Paris, France.
Interleukin-10 (IL-10) is constitutively produced by peritoneal B1a
lymphocytes, and stromal cell-derived factor-1 (SDF-1) by mesothelial
cells. Independent studies have shown that both IL-10 and SDF-1 are
involved in the persistence of the peritoneal B-lymphocyte compartment.
This study shows that IL-10 and SDF-1 act in synergy on peritoneal B
lymphocytes. Indeed, autocrine production of IL-10 was absolutely
required for all effects of SDF-1 on these cells, including increased
proliferation, survival, and chemotaxis. Moreover, adding IL-10 to
peritoneal B lymphocytes increased the effects of SDF-1. Neither IL-5,
IL-6, nor IL-9 affected the response of peritoneal B lymphocytes to
SDF-1. IL-10 was chemokinetic for peritoneal B lymphocytes, increasing
their random mobility. It also potentiated the SDF-1-induced
reorganization of the cytoskeleton without affecting CXCR4 gene
expression by peritoneal B lymphocytes. Despite its chemokinetic
properties, IL-10 abolished the migration of peritoneal B lymphocytes
in response to B-lymphocyte chemoattractant (BLC), a chemokine
targeting B lymphocytes to lymphoid organ follicles. The ability of B1a
lymphocytes to produce IL-10 constitutively, combined with the opposite
effects of this cytokine on the responses to SDF-1 and BLC, may account
for the selective accumulation of B1 lymphocytes in body cavities.
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