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Blood, 15 January 2002, Vol. 99, No. 2, pp. 561-566
IMMUNOBIOLOGY
Quantitative trait loci regulating relative lymphocyte
proportions in mouse peripheral blood
Jichun Chen and
David E. Harrison
From The Jackson Laboratory, Bar Harbor, ME.
Relative proportions of peripheral blood (PB) B lymphocytes
(B220%) as well as CD4 (CD4%) and CD8 (CD8%) T lymphocytes
differ significantly among inbred mouse strains: B220% is high in
C57BL/6J (B6) and C57BR/cdJ, intermediate in BALB/cByJ (BALB) and
DBA/2J (D2), and low in NOD/LtJ (NOD) and SJL/J (SJL) mice, whereas
CD4% and CD8% are high in NOD and SJL mice and low in the other 4 strains. By following segregating genetic markers linked to these
traits in (B6 × D2) recombinant inbred (BXD RI) mice, the study
defined 2 quantitative trait loci (QTLs) for the B220% phenotype:
Pbbcp1 (peripheral blood B cell percentage 1, logarithm of
odds [LOD] 4.1, P < .000 01) and Pbbcp2
(LOD 3.7, P < .000 04) on chromosome 1 (Chr 1) at about
63 cM and 48 cM; one suggestive locus for the CD4% phenotype (LOD 2.6, P < .000 57) on Chr 8 at about 73 cM; and one QTL for
the CD8% phenotype: Pbctlp1 (peripheral blood cytotoxic T
lymphocyte percentage 1, LOD 3.8, P < .000 02) on Chr
19 at about 12 cM. The study further segregated PB lymphocyte proportions in B6SJLF2 mice by using DNA markers adjacent to these mapped QTLs and found that the Pbbcp1 locus (LOD 5.6, P < .000 01) was also important in this mouse
population. In both BXD RI and B6SJLF2 mice, QTLs regulating B-cell
proportions showed no significant effect on T-cell proportions and vice
versa. Thus, PB B- and T-lymphocyte proportions are regulated
separately by different genetic elements.
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