|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 January 2002, Vol. 99, No. 2, pp. 694-697
BRIEF REPORT
PTEN controls immunoreceptor (immunoreceptor tyrosine-based
activation motif) signaling and the activation of Rac
Jong Suk Kim,
Xiaodong Peng,
Pradip K. De,
Robert L. Geahlen, and
Donald
L. Durden
From the Departments of Pediatrics, Biochemistry, and
Molecular Biology, Herman B. Wells Center for Pediatric Research,
Indiana University School of Medicine, Indianapolis; and the Department
of Medicinal Chemistry and Molecular Pharmacology, Purdue University,
West Lafayette, IN.
Fc receptor-mediated phagocytosis is a model for the
study of immunoreceptor (immunoreceptor tyrosine-based activation motif [ITAM]) signaling and involves the activation of protein tyrosine kinases, protein tyrosine phosphatases, and downstream effectors including phosphatidylinositol-3 (PI-3) kinase. Relatively little is
known of the role of lipid phosphatases in the control of ITAM signaling and inflammation. A heterologous COS7 cell system was used to examine the roles played by PI-3 kinase and the
dual-specificity phosphatase, phosphatase and tensin homolog deleted on
chromosome 10 (PTEN), in the signal transduction pathway leading to
Fc receptor IIA-mediated phagocytosis and the activation of Rac.
The expression of wildtype PTEN completely abrogated the phagocytosis
of immunoglobulin-G-sensitized sheep red blood cells, as
compared with the catalytically inactive mutant of PTEN, which had no
effect. This is the first direct evidence that PTEN, an inositol 3'
phosphatase, regulates Fc receptor-mediated phagocytosis, an
ITAM-based signaling event. The data suggest that PTEN exerts control
over phagocytosis potentially by controlling the downstream
conversion of guanosine diphosphate-Rac to guanosine triphosphate-Rac
following ITAM stimulation.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
C. Canetti, C. H. Serezani, R. G. Atrasz, E. S. White, D. M. Aronoff, and M. Peters-Golden
Activation of Phosphatase and Tensin Homolog on Chromosome 10 Mediates the Inhibition of Fc{gamma}R Phagocytosis by Prostaglandin E2 in Alveolar Macrophages
J. Immunol.,
December 15, 2007;
179(12):
8350 - 8356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. A. Kamen, J. Levinsohn, and J. A. Swanson
Differential Association of Phosphatidylinositol 3-Kinase, SHIP-1, and PTEN with Forming Phagosomes
Mol. Biol. Cell,
July 1, 2007;
18(7):
2463 - 2472.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Ai, A. Maturu, W. Johnson, Y. Wang, C. B. Marsh, and S. Tridandapani
The inositol phosphatase SHIP-2 down-regulates Fc{gamma}R-mediated phagocytosis in murine macrophages independently of SHIP-1
Blood,
January 15, 2006;
107(2):
813 - 820.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L.-A. H. Allen, J. A. Allgood, X. Han, and L. M. Wittine
Phosphoinositide3-kinase regulates actin polymerization during delayed phagocytosis of Helicobacter pylori
J. Leukoc. Biol.,
July 1, 2005;
78(1):
220 - 230.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. D. Moon, C. B. Post, D. L. Durden, Q. Zhou, P. De, M. L. Harrison, and R. L. Geahlen
Molecular Basis for a Direct Interaction between the Syk Protein-tyrosine Kinase and Phosphoinositide 3-Kinase
J. Biol. Chem.,
January 14, 2005;
280(2):
1543 - 1551.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. A. Swanson and A. D. Hoppe
The coordination of signaling during Fc receptor-mediated phagocytosis
J. Leukoc. Biol.,
December 1, 2004;
76(6):
1093 - 1103.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
X. Cao, G. Wei, H. Fang, J. Guo, M. Weinstein, C. B. Marsh, M. C. Ostrowski, and S. Tridandapani
The Inositol 3-Phosphatase PTEN Negatively Regulates Fc{gamma} Receptor Signaling, but Supports Toll-Like Receptor 4 Signaling in Murine Peritoneal Macrophages
J. Immunol.,
April 15, 2004;
172(8):
4851 - 4857.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. van Mirre, A. van Royen, C. E. Hack, A. R. Crow, S. Song, J. Freedman, C. D. Helgason, R. K. Humphries, K. A. Siminovitch, and A. H. Lazarus
IVIg-mediated amelioration of murine ITP via Fc{gamma}RIIb is not necessarily independent of SHIP-1 and SHP-1 activity
Blood,
March 1, 2004;
103(5):
1973 - 1974.
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Pradip, X. Peng, and D. L. Durden
Rac2 Specificity in Macrophage Integrin Signaling: POTENTIAL ROLE FOR Syk KINASE
J. Biol. Chem.,
October 24, 2003;
278(43):
41661 - 41669.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. D. Su, L. D. Mayo, D. B. Donner, and D. L. Durden
PTEN and Phosphatidylinositol 3'-Kinase Inhibitors Up-Regulate p53 and Block Tumor-induced Angiogenesis: Evidence for an Effect on the Tumor and Endothelial Compartment
Cancer Res.,
July 1, 2003;
63(13):
3585 - 3592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. A. Pengal, L. P. Ganesan, H. Fang, C. B. Marsh, C. L. Anderson, and S. Tridandapani
SHIP-2 Inositol Phosphatase Is Inducibly Expressed in Human Monocytes and Serves to Regulate Fc{gamma} Receptor-mediated Signaling
J. Biol. Chem.,
June 13, 2003;
278(25):
22657 - 22663.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Vidal, B. Geny, J. Melle, M. Jandrot-Perrus, and M. Fontenay-Roupie
Cdc42/Rac1-dependent activation of the p21-activated kinase (PAK) regulates human platelet lamellipodia spreading: implication of the cortical-actin binding protein cortactin
Blood,
December 15, 2002;
100(13):
4462 - 4469.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. M. Kant, P. De, X. Peng, T. Yi, D. J. Rawlings, J. S. Kim, and D. L. Durden
SHP-1 regulates Fcgamma receptor-mediated phagocytosis and the activation of RAC
Blood,
August 13, 2002;
100(5):
1852 - 1859.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
