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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kang, E. M. Articles by Tisdale, J. F. Search for Related Content PubMed PubMed Citation Articles by Kang, E. M. Articles by Tisdale, J. F. Related Collections Transplantation Immunotherapy Brief Reports Clinical Trials and Observations Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2002, Vol. 99, No. 2, pp. 698-701 BRIEF REPORT Nonmyeloablative conditioning followed by transplantation of genetically modified HLA-matched peripheral blood progenitor cells for hematologic malignancies in patients with acquired immunodeficiency syndrome Elizabeth M. Kang, Moniek de Witte, Harry Malech, Richard A. Morgan, Sheila Phang, Charles Carter, Susan F. Leitman, Richard Childs, A. John Barrett, Richard Little, and John F. Tisdale From the Molecular and Clinical Hematology Branch, National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; National Human Genome Research Institute; Department of Nursing and Department of Transfusion Medicine, Clinical Center; National Heart, Lung, and Blood Institute; and National Cancer Institute, National Institutes of Health, Bethesda, MD. To assess the safety and efficacy of nonmyeloablative allogeneic transplantation in patients with HIV infection, a clinical protocol was initiated in patients with refractory hematologic malignancies and concomitant HIV infection. The results from the first 2 patients are reported. The indications for transplantation were treatment-related acute myelogenous leukemia and primary refractory Hodgkin disease in patients 1 and 2, respectively. Only patient 1 received genetically modified cells. Both patients tolerated the procedure well with minimal toxicity, and complete remissions were achieved in both patients, but patient 2 died of relapsed Hodgkin disease 12 months after transplantation. Patient 1 continues in complete remission with undetectable HIV levels and rising CD4 counts, and with both the therapeutic and control gene transfer vectors remaining detectable at low levels more than 2 years after transplantation. These results suggest that nonmyeloablative allogeneic transplantation in the context of highly active antiretroviral therapy is feasible in patients with treatment-sensitive HIV infection. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Hamadani and S. M. Devine Reduced-intensity conditioning allogeneic stem cell transplantation in HIV patients with hematologic malignancies: yes, we can Blood, September 17, 2009; 114(12): 2564 - 2566. [Full Text] [PDF] J. Hayakawa, M. Hsieh, N. Uchida, K. Washington, O. Phang, E. Kang, and J. F. Tisdale Long-Term Vector Integration Site Analysis Following Retroviral Mediated Gene Transfer to Hematopoietic Stem Cells for the Treatment of HIV Infection. Blood (ASH Annual Meeting Abstracts), November 16, 2008; 112(11): 2350 - 2350. [Abstract] A. E. Woolfrey, U. Malhotra, R. D. Harrington, J. McNevin, T. J. Manley, S. R. Riddell, R. W. Coombs, F. R. Appelbaum, L. Corey, and R. Storb Generation of HIV-1-specific CD8+ cell responses following allogeneic hematopoietic cell transplantation Blood, October 15, 2008; 112(8): 3484 - 3487. [Abstract] [Full Text] [PDF] G. C. Persad, R. F. Little, and C. Grady Including Persons With HIV Infection in Cancer Clinical Trials J. Clin. Oncol., March 1, 2008; 26(7): 1027 - 1032. [Full Text] [PDF] T. Wolf, V. Rickerts, S. Staszewski, S. Kriener, B. Wassmann, G. Bug, M. Bickel, P. Gute, H.R. Brodt, and H. Martin First case of successful allogeneic stem cell transplantation in an HIV-patient who acquired severe Aplastic Anemia Haematologica, April 1, 2007; 92(4): e56 - e58. [Abstract] [Full Text] [PDF] W. H. Navarro and L. D. Kaplan AIDS-related lymphoproliferative disease Blood, January 1, 2006; 107(1): 13 - 20. [Abstract] [Full Text] [PDF] T. Ueda, S. Brenner, H. L. Malech, S. M. Langemeijer, S. Perl, M. Kirby, O. A. Phang, A. E. Krouse, R. E. Donahue, E. M. Kang, et al. Cloning and Functional Analysis of the Rhesus Macaque ABCG2 Gene: FORCED EXPRESSION CONFERS AN SP PHENOTYPE AMONG HEMATOPOIETIC STEM CELL PROGENY IN VIVO J. Biol. Chem., January 14, 2005; 280(2): 991 - 998. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020