SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Adinolfi, E. Articles by Baricordi, O. R. Search for Related Content PubMed PubMed Citation Articles by Adinolfi, E. Articles by Baricordi, O. R. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2002, Vol. 99, No. 2, pp. 706-708 BRIEF REPORT P2X7 receptor expression in evolutive and indolent forms of chronic B lymphocytic leukemia Elena Adinolfi, Loredana Melchiorri, Simonetta Falzoni, Paola Chiozzi, Anna Morelli, Alessia Tieghi, Antonio Cuneo, Gianluigi Castoldi, Francesco Di Virgilio, and Olavio R. Baricordi From the Department of Experimental and Diagnostic Medicine, Section of Medical Genetics and General Pathology; Department of Biomedical Sciences and Advanced Therapy, Section of Hematology; and Center for the Study of Inflammatory Diseases; University of Ferrara, Italy. Human leukocytes express a receptor for extracellular nucleotides, named P2X7R, that in lymphocytes can either mediate cell death or proliferation, depending on the level of activation. The authors have investigated P2X7R expression and function in 21 patients affected by B-cell chronic lymphocytic leukemia, 13 with an evolutive and 8 with an indolent variant of the disease. Resting cytoplasmic Ca++ concentration was significantly higher in lymphocytes from patients with the evolutive compared with indolent variant. Furthermore, in the former, P2X7R stimulation triggered a Ca++ influx significantly larger. Higher Ca++ influx correlated with an increased P2X7R expression in the lymphocytes from patients with the evolutive form. Finally, incubation in the presence of extracellular adenosine triphosphate decreased spontaneous proliferation of lymphocytes from patients affected with the evolutive variant but had no effects on lymphocytes from patients with the indolent form. These results suggest that expression and function of P2X7R may correlate with the severity of B-cell chronic lymphocytic leukemia. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: L. Yip, T. Woehrle, R. Corriden, M. Hirsh, Y. Chen, Y. Inoue, V. Ferrari, P. A. Insel, and W. G. Junger Autocrine regulation of T-cell activation by ATP release and P2X7 receptors FASEB J, June 1, 2009; 23(6): 1685 - 1693. [Abstract] [Full Text] [PDF] E. Adinolfi, M. G. Callegari, M. Cirillo, P. Pinton, C. Giorgi, D. Cavagna, R. Rizzuto, and F. Di Virgilio Expression of the P2X7 Receptor Increases the Ca2+ Content of the Endoplasmic Reticulum, Activates NFATc1, and Protects from Apoptosis J. Biol. Chem., April 10, 2009; 284(15): 10120 - 10128. [Abstract] [Full Text] [PDF] A. Solini, S. Cuccato, D. Ferrari, E. Santini, S. Gulinelli, M. G. Callegari, A. Dardano, P. Faviana, S. Madec, F. Di Virgilio, et al. Increased P2X7 Receptor Expression and Function in Thyroid Papillary Cancer: A New Potential Marker of the Disease? Endocrinology, January 1, 2008; 149(1): 389 - 396. [Abstract] [Full Text] [PDF] M. Dutot, F. Pouzaud, I. Larosche, F. Brignole-Baudouin, J.-M. Warnet, and P. Rat Fluoroquinolone Eye Drop-Induced Cytotoxicity: Role of Preservative in P2X7 Cell Death Receptor Activation and Apoptosis. Invest. Ophthalmol. Vis. Sci., July 1, 2006; 47(7): 2812 - 2819. [Abstract] [Full Text] [PDF] G. Burnstock Pathophysiology and therapeutic potential of purinergic signaling. Pharmacol. Rev., March 1, 2006; 58(1): 58 - 86. [Abstract] [Full Text] [PDF] L. Chen and C. F. Brosnan Exacerbation of Experimental Autoimmune Encephalomyelitis in P2X7R-/- Mice: Evidence for Loss of Apoptotic Activity in Lymphocytes. J. Immunol., March 1, 2006; 176(5): 3115 - 3126. [Abstract] [Full Text] [PDF] L. Raffaghello, P. Chiozzi, S. Falzoni, F. Di Virgilio, and V. Pistoia The P2X7 Receptor Sustains the Growth of Human Neuroblastoma Cells through a Substance P-Dependent Mechanism Cancer Res., January 15, 2006; 66(2): 907 - 914. [Abstract] [Full Text] [PDF] G. Cabrini, S. Falzoni, S. L. Forchap, P. Pellegatti, A. Balboni, P. Agostini, A. Cuneo, G. Castoldi, O. R. Baricordi, and F. Di Virgilio A His-155 to Tyr Polymorphism Confers Gain-of-Function to the Human P2X7 Receptor of Human Leukemic Lymphocytes J. Immunol., July 1, 2005; 175(1): 82 - 89. [Abstract] [Full Text] [PDF] E. Adinolfi, M. G. Callegari, D. Ferrari, C. Bolognesi, M. Minelli, M. R. Wieckowski, P. Pinton, R. Rizzuto, and F. Di Virgilio Basal Activation of the P2X7 ATP Receptor Elevates Mitochondrial Calcium and Potential, Increases Cellular ATP Levels, and Promotes Serum-independent Growth Mol. Biol. Cell, July 1, 2005; 16(7): 3260 - 3272. [Abstract] [Full Text] [PDF] D. Ferrari, C. Pizzirani, E. Adinolfi, S. Forchap, B. Sitta, L. Turchet, S. Falzoni, M. Minelli, R. Baricordi, and F. Di Virgilio The Antibiotic Polymyxin B Modulates P2X7 Receptor Function J. Immunol., October 1, 2004; 173(7): 4652 - 4660. [Abstract] [Full Text] [PDF] R. M. Lemoli, D. Ferrari, M. Fogli, L. Rossi, C. Pizzirani, S. Forchap, P. Chiozzi, D. Vaselli, F. Bertolini, T. Foutz, et al. Extracellular nucleotides are potent stimulators of human hematopoietic stem cells in vitro and in vivo Blood, September 15, 2004; 104(6): 1662 - 1670. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020