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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fenton, J. A. L. Articles by Kluin, P. M. Search for Related Content PubMed PubMed Citation Articles by Fenton, J. A. L. Articles by Kluin, P. M. Related Collections Neoplasia Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 January 2002, Vol. 99, No. 2, pp. 716-718 BRIEF REPORT Follicular lymphoma with a novel t(14;18) breakpoint involving the immunoglobulin heavy chain switch mu region indicates an origin from germinal center B cells James A. L. Fenton, Jan-Willem Vaandrager, Wilhelmina M. Aarts, Richard J. Bende, Karel Heering, Martin van Dijk, Gareth Morgan, Carel J. M. van Noesel, Ed Schuuring, and Philip M. Kluin From the Department of Pathology, Leiden University Medical Center, The Netherlands; Department of Haematology, University of Leeds, United Kingdom; Department of Pathology, University of Amsterdam, The Netherlands; Departments of Internal Medicine and Clinical Pathology, Groene Hart Hospital, Gouda, The Netherlands. With the use of DNA-fiber fluorescent in situ hybridization, a BCL2 protein positive follicular lymphoma with a novel BCL2 breakpoint involving the immunoglobulin heavy chain (IGH) switch mu (Sµ) region instead of the JH or DH gene segments was identified. Sequence analysis showed that the genomic breakpoint is localized between the Sµ region of the IGH complex and the first intron of BCL2. Reverse-transcriptase polymerase chain reaction showed expression of a unique hybrid IGH-BCL2 transcript involving the transcription initiation site Iµ. Sequence analysis of the VH region of the functional nontranslocated IGH allele showed multiple shared somatic mutations but also a high intraclonal variation (53 differences in 15 clones), compatible with the lymphoma cells staying in or re-entering the germinal center. This is the first example of a t(14;18) translocation that results from an illegitimate IGH class-switch recombination during the germinal center B-cell stage. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: D. LeBrun, T. Baetz, C. Foster, P. Farmer, R. Sidhu, H. Guo, K. Harrison, R. Somogyi, L. D. Greller, and H. Feilotter Predicting Outcome in Follicular Lymphoma by Using Interactive Gene Pairs Clin. Cancer Res., January 15, 2008; 14(2): 478 - 487. [Abstract] [Full Text] [PDF] G Kocjan BEST PRACTICE No 185 Cytological and molecular diagnosis of lymphoma J. Clin. Pathol., June 1, 2005; 58(6): 561 - 567. [Abstract] [Full Text] [PDF] P L Roddam, S Rollinson, M O'Driscoll, P A Jeggo, A Jack, and G J Morgan Genetic variants of NHEJ DNA ligase IV can affect the risk of developing multiple myeloma, a tumour characterised by aberrant class switch recombination J. Med. Genet., December 1, 2002; 39(12): 900 - 905. [Abstract] [Full Text] [PDF] W. M. Aarts, R. J. Bende, J.-W. Vaandrager, P. M. Kluin, A. W. Langerak, S. T. Pals, and C. J.M. van Noesel In Situ Analysis of the Variable Heavy Chain Gene of an IgM/IgG-Expressing Follicular Lymphoma : Evidence for Interfollicular Trafficking of Tumor Cells Am. J. Pathol., March 1, 2002; 160(3): 883 - 891. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020