Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hamblin, T. J.
Right arrow Articles by Oscier, D. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hamblin, T. J.
Right arrow Articles by Oscier, D. G.
Related Collections
Right arrow Neoplasia
Right arrowRelated Letters in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 1 February 2002, Vol. 99, No. 3, pp. 1023-1029

NEOPLASIA

CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease

Terry J. Hamblin, Jenny A. Orchard, Rachel E. Ibbotson, Zadie Davis, Peter W. Thomas, Freda K. Stevenson, and David G. Oscier

From the Department of Haematology, Royal Bournemouth Hospital, United Kingdom; the Dorset Research and Development Support Unit, Poole Hospital, United Kingdom; the Institute of Health and Community Studies, Bournemouth University, United Kingdom; and the Molecular Immunology Department, Tenovus Research Laboratory, Southampton General Hospital, United Kingdom.

Although the presence or absence of somatic mutations in the immunoglobulin variable region (IgVH) genes in chronic lymphocytic leukemia (B-CLL) identifies subtypes with very different prognoses, the assay is technically complex and unavailable to most laboratories. CD38 expression has been suggested as a surrogate marker for the 2 subtypes. IgVH mutations and CD38 expression in 145 patients with B-CLL with a long follow-up were compared. The 2 assays gave discordant results in 41 patients (28.3%). Multivariate analysis demonstrated that Binet stage, IgVH mutations and CD38 were independent prognostic indicators. Median survival time in patients whose cells had unmutated IgVH genes and expressed CD38 was 8 years; in those with mutated IgVH genes not expressing CD38, it was 26 years. For those with discordant results, median survival time was 15 years. Thus, although CD38 expression does not identify the same 2 subsets as IgVH mutations in CLL, it is an independent risk factor that can be used with IgVH mutations and clinical stage to select patients with B-CLL with the worst prognoses. Using cryopreserved cells taken at intervals during the course of the disease, however, changes of CD38 expression over time were demonstrated in 10 of 41 patients. Causes of the variation of CD38 expression require further study. Additional prospective studies are required for comparing CD38 expression with other prognostic factors and for taking sequential measurements during the course of the disease.

© 2002 by The American Society of Hematology.
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Letters in Blood Online:

Conversion of CD38 and/or myeloid-associated marker expression status during the course of B-CLL: association with a change to an aggressive clinical course
Chung-Che Chang and Ronald P. Cleveland
Blood 2002 100: 1106. [Full Text] [PDF]

CD38 expression does not change in B-cell chronic lymphocytic leukemia
Giovanni D'Arena, Giuseppe Nunziata, Giuseppe Coppola, Maria Luigia Vigliotti, Alfredo Tartarone, Nicola Carpinelli, Rosella Matera, Rosario Colella Bisogno, Giuseppe Pistolese, and Nicola Di Renzo
Blood 2002 100: 3052. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
L. Kujawski, P. Ouillette, H. Erba, C. Saddler, A. Jakubowiak, M. Kaminski, K. Shedden, and S. N. Malek
Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia
Blood, September 1, 2008; 112(5): 1993 - 2003.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Z. Rassenti, S. Jain, M. J. Keating, W. G. Wierda, M. R. Grever, J. C. Byrd, N. E. Kay, J. R. Brown, J. G. Gribben, D. S. Neuberg, et al.
Relative value of ZAP-70, CD38, and immunoglobulin mutation status in predicting aggressive disease in chronic lymphocytic leukemia
Blood, September 1, 2008; 112(5): 1923 - 1930.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
F. Malavasi, S. Deaglio, A. Funaro, E. Ferrero, A. L. Horenstein, E. Ortolan, T. Vaisitti, and S. Aydin
Evolution and Function of the ADP Ribosyl Cyclase/CD38 Gene Family in Physiology and Pathology
Physiol Rev, July 1, 2008; 88(3): 841 - 886.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. J. Hamblin
Ligandless receptors find a role
Blood, July 1, 2008; 112(1): 2 - 3.
[Full Text] [PDF]

Home page
 BloodHome page
F. J. Li, S. Ding, J. Pan, M. A. Shakhmatov, E. Kashentseva, J. Wu, Y. Li, S.-j. Soong, N. Chiorazzi, and R. S. Davis
FCRL2 expression predicts IGHV mutation status and clinical progression in chronic lymphocytic leukemia
Blood, July 1, 2008; 112(1): 179 - 187.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Aydin, D. Rossi, L. Bergui, G. D'Arena, E. Ferrero, L. Bonello, P. Omede, D. Novero, F. Morabito, A. Carbone, et al.
CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome?
Blood, June 15, 2008; 111(12): 5646 - 5653.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. E. M. Patten, A. G. S. Buggins, J. Richards, A. Wotherspoon, J. Salisbury, G. J. Mufti, T. J. Hamblin, and S. Devereux
CD38 expression in chronic lymphocytic leukemia is regulated by the tumor microenvironment
Blood, May 15, 2008; 111(10): 5173 - 5181.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. E. Craig and K. A. Foon
Flow cytometric immunophenotyping for hematologic neoplasms
Blood, April 15, 2008; 111(8): 3941 - 3967.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
G. Cutrona, M. Colombo, S. Matis, M. Fabbi, M. Spriano, V. Callea, E. Vigna, M. Gentile, S. Zupo, N. Chiorazzi, et al.
Clonal heterogeneity in chronic lymphocytic leukemia cells: superior response to surface IgM cross-linking in CD38, ZAP-70-positive cells
Haematologica, March 1, 2008; 93(3): 413 - 422.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Roos, A. Krober, P. Grabowski, D. Kienle, A. Buhler, H. Dohner, R. Rosenquist, and S. Stilgenbauer
Short telomeres are associated with genetic complexity, high-risk genomic aberrations, and short survival in chronic lymphocytic leukemia
Blood, February 15, 2008; 111(4): 2246 - 2252.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Gattei, P. Bulian, M. I. Del Principe, A. Zucchetto, L. Maurillo, F. Buccisano, R. Bomben, M. Dal-Bo, F. Luciano, F. M. Rossi, et al.
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
Blood, January 15, 2008; 111(2): 865 - 873.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
A. W. Hauswirth and U. Jager
Impact of cytogenetic and molecular prognostic markers on the clinical management of chronic lymphocytic leukemia
Haematologica, January 1, 2008; 93(1): 14 - 19.
[Full Text] [PDF]

Home page
 BloodHome page
S. Deaglio, T. Vaisitti, S. Aydin, L. Bergui, G. D'Arena, L. Bonello, P. Omede, M. Scatolini, O. Jaksic, G. Chiorino, et al.
CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential
Blood, December 1, 2007; 110(12): 4012 - 4021.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. M. Tsimberidou, S. Wen, S. O'Brien, P. McLaughlin, W. G. Wierda, A. Ferrajoli, S. Faderl, J. Manning, S. Lerner, C. V. Mai, et al.
Assessment of Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma by Absolute Lymphocyte Counts in 2,126 Patients: 20 Years of Experience at The University of Texas M.D. Anderson Cancer Center
J. Clin. Oncol., October 10, 2007; 25(29): 4648 - 4656.
[Abstract] [Full Text] [PDF]

Home page
 haematolHome page
S. Willimott, M. Baou, S. Huf, S. Deaglio, and S. D. Wagner
Regulation of CD38 in proliferating chronic lymphocytic leukemia cells stimulated with CD154 and interleukin-4
Haematologica, October 1, 2007; 92(10): 1359 - 1366.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Chem.Home page
B. Stamatopoulos, N. Meuleman, B. Haibe-Kains, H. Duvillier, M. Massy, P. Martiat, D. Bron, and L. Lagneaux
Quantification of ZAP70 mRNA in B Cells by Real-Time PCR Is a Powerful Prognostic Factor in Chronic Lymphocytic Leukemia
Clin. Chem., October 1, 2007; 53(10): 1757 - 1766.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. D. Joshi, G. V. Hegde, J. D. Dickinson, A. K. Mittal, J. C. Lynch, J. D. Eudy, J. O. Armitage, P. J. Bierman, R. G. Bociek, M. P. Devetten, et al.
ATM, CTLA4, MNDA, and HEM1 in High versus Low CD38 Expressing B-Cell Chronic Lymphocytic Leukemia
Clin. Cancer Res., September 15, 2007; 13(18): 5295 - 5304.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E. Sabattini, R. Orduz, C. Campidelli, P. L. Zinzani, V. Callea, S. Zupo, G. Cutrona, F. Morabito, M. Ferrarini, and S. Pileri
B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens
J. Clin. Pathol., June 1, 2007; 60(6): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
I. Tinhofer, G. Rubenzer, C. Holler, E. Hofstaetter, M. Stoecher, A. Egle, M. Steurer, and R. Greil
Expression levels of CD38 in T cells predict course of disease in male patients with B-chronic lymphocytic leukemia
Blood, November 1, 2006; 108(9): 2950 - 2956.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
T. D. Shanafelt, T. E. Witzig, S. R. Fink, R. B. Jenkins, S. F. Paternoster, S. A. Smoley, K. J. Stockero, D. M. Nast, H. C. Flynn, R. C. Tschumper, et al.
Prospective Evaluation of Clonal Evolution During Long-Term Follow-Up of Patients With Untreated Early-Stage Chronic Lymphocytic Leukemia
J. Clin. Oncol., October 1, 2006; 24(28): 4634 - 4641.
[Abstract] [Full Text] [PDF]

Home page
 ANN INTERN MEDHome page
T. D. Shanafelt, J. C. Byrd, T. G. Call, C. S. Zent, and N. E. Kay
Narrative review: initial management of newly diagnosed, early-stage chronic lymphocytic leukemia.
Ann Intern Med, September 19, 2006; 145(6): 435 - 447.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. I. Del Principe, G. Del Poeta, F. Buccisano, L. Maurillo, A. Venditti, A. Zucchetto, R. Marini, P. Niscola, M. A. I. Consalvo, C. Mazzone, et al.
Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia
Blood, August 1, 2006; 108(3): 853 - 861.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. de Totero, R. Meazza, S. Zupo, G. Cutrona, S. Matis, M. Colombo, E. Balleari, I. Pierri, M. Fabbi, M. Capaia, et al.
Interleukin-21 receptor (IL-21R) is up-regulated by CD40 triggering and mediates proapoptotic signals in chronic lymphocytic leukemia B cells
Blood, May 1, 2006; 107(9): 3708 - 3715.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
I. Hus, M. Podhorecka, A. Bojarska-Junak, J. Rolinski, M. Schmitt, M. Sieklucka, E. Wasik-Szczepanek, and A. Dmoszynska
The clinical significance of ZAP-70 and CD38 expression in B-cell chronic lymphocytic leukaemia
Ann. Onc., April 1, 2006; 17(4): 683 - 690.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
J. C. Byrd, J. G. Gribben, B. L. Peterson, M. R. Grever, G. Lozanski, D. M. Lucas, B. Lampson, R. A. Larson, M. A. Caligiuri, and N. A. Heerema
Select High-Risk Genetic Features Predict Earlier Progression Following Chemoimmunotherapy With Fludarabine and Rituximab in Chronic Lymphocytic Leukemia: Justification for Risk-Adapted Therapy
J. Clin. Oncol., January 20, 2006; 24(3): 437 - 443.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Stamatopoulos, C. Belessi, A. Hadzidimitriou, T. Smilevska, E. Kalagiakou, K. Hatzi, N. Stavroyianni, A. Athanasiadou, A. Tsompanakou, T. Papadaki, et al.
Immunoglobulin light chain repertoire in chronic lymphocytic leukemia
Blood, November 15, 2005; 106(10): 3575 - 3583.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
R. Marasca, R. Maffei, M. Morselli, P. Zucchini, I. Castelli, S. Martinelli, M. Fontana, S. Ravanetti, M. Curotti, G. Leonardi, et al.
Immunoglobulin Mutational Status Detected through Single-Round Amplification of Partial VH Region Represents a Good Prognostic Marker for Clinical Outcome in Chronic Lymphocytic Leukemia
J. Mol. Diagn., November 1, 2005; 7(5): 566 - 574.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
D. Caballero, J. A. Garcia-Marco, R. Martino, V. Mateos, J. M. Ribera, J. Sarra, A. Leon, G. Sanz, J. de la Serna, R. Cabrera, et al.
Allogeneic Transplant with Reduced Intensity Conditioning Regimens may Overcome the Poor Prognosis of B-Cell Chronic Lymphocytic Leukemia with Unmutated Immunoglobulin Variable Heavy-Chain Gene and Chromosomal Abnormalities (11q- and 17p-)
Clin. Cancer Res., November 1, 2005; 11(21): 7757 - 7763.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Ruiz-Ballesteros, M. Mollejo, A. Rodriguez, F. I. Camacho, P. Algara, N. Martinez, M. Pollan, A. Sanchez-Aguilera, J. Menarguez, E. Campo, et al.
Splenic marginal zone lymphoma: proposal of new diagnostic and prognostic markers identified after tissue and cDNA microarray analysis
Blood, September 1, 2005; 106(5): 1831 - 1838.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
L. V. Abruzzo, J. Wang, M. Kapoor, L. J. Medeiros, M. J. Keating, W. E. Highsmith, L. L. Barron, C. C. Cromwell, and K. R. Coombes
Biological Validation of Differentially Expressed Genes in Chronic Lymphocytic Leukemia Identified by Applying Multiple Statistical Methods to Oligonucleotide Microarrays
J. Mol. Diagn., August 1, 2005; 7(3): 337 - 345.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Oppezzo, Y. Vasconcelos, C. Settegrana, D. Jeannel, F. Vuillier, M. Legarff-Tavernier, E. Y. Kimura, S. Bechet, G. Dumas, M. Brissard, et al.
The LPL/ADAM29 expression ratio is a novel prognosis indicator in chronic lymphocytic leukemia
Blood, July 15, 2005; 106(2): 650 - 657.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Petlickovski, L. Laurenti, X. Li, S. Marietti, P. Chiusolo, S. Sica, G. Leone, and D. G. Efremov
Sustained signaling through the B-cell receptor induces Mcl-1 and promotes survival of chronic lymphocytic leukemia B cells
Blood, June 15, 2005; 105(12): 4820 - 4827.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. L. Sorror, M. B. Maris, B. M. Sandmaier, B. E. Storer, M. J. Stuart, U. Hegenbart, E. Agura, T. R. Chauncey, J. Leis, M. Pulsipher, et al.
Hematopoietic Cell Transplantation After Nonmyeloablative Conditioning for Advanced Chronic Lymphocytic Leukemia
J. Clin. Oncol., June 1, 2005; 23(16): 3819 - 3829.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
N. Chiorazzi, K. R. Rai, and M. Ferrarini
Chronic Lymphocytic Leukemia
N. Engl. J. Med., February 24, 2005; 352(8): 804 - 815.
[Full Text] [PDF]

Home page
 BloodHome page
H. Nuckel, V. Rebmann, J. Durig, U. Duhrsen, and H. Grosse-Wilde
HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia
Blood, February 15, 2005; 105(4): 1694 - 1698.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. W. Milligan, S. Fernandes, R. Dasgupta, F. E. Davies, E. Matutes, C. D. Fegan, C. McConkey, J. A. Child, D. Cunningham, G. J. Morgan, et al.
Results of the MRC pilot study show autografting for younger patients with chronic lymphocytic leukemia is safe and achieves a high percentage of molecular responses
Blood, January 1, 2005; 105(1): 397 - 404.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
A. Rodriguez, N. Martinez, F. I. Camacho, E. Ruiz-Ballesteros, P. Algara, J.-F. Garcia, J. Menarguez, T. Alvaro, M. F. Fresno, F. Solano, et al.
Variability in the Degree of Expression of Phosphorylated I{kappa}B{alpha} in Chronic Lymphocytic Leukemia Cases With Nodal Involvement
Clin. Cancer Res., October 15, 2004; 10(20): 6796 - 6806.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. F. Widhopf II, L. Z. Rassenti, T. L. Toy, J. G. Gribben, W. G. Wierda, and T. J. Kipps
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
Blood, October 15, 2004; 104(8): 2499 - 2504.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
E. Montserrat
Assessing prognosis in patients with chronic lymphocytic leukemia a quarter of a century after Rai and Binet staging systems