|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 February 2002, Vol. 99, No. 3, pp. 1089-1091
BRIEF REPORT
Sustained suppression of hepatitis C virus by interferon
and ribavirin in hemophilic patients not responding to
interferon monotherapy
Elena Santagostino,
Maria
Grazia Rumi,
Monica Rivi,
Massimo Colombo, and
Pier Mannuccio Mannucci for the Hepatitis Study Group of
the Association of Italian Hemophilia
Centers
From the Angelo Bianchi Bonomi Hemophilia and
Thrombosis Center and Division of Hepatology, IRCCS Maggiore Hospital,
University of Milan, Italy.
Thirty-nine hemophiliac patients, negative for human
immunodeficiency virus, with chronic hepatitis C who failed to respond to interferon (IFN) at 3 million units (MU) given
subcutaneously thrice weekly for at least 3 months were retreated with
5 MU IFN for 6 months followed by 3 MU IFN in combination with daily
oral doses of 1 or 1.2 g ribavirin. Thirty-four patients (87%)
completed the study. In 4 patients treatment was discontinued because
of treatment-related symptoms; 1 patient dropped out. Dosage reduction was required in 10 patients (26%) because of ribavirin-related anemia
or IFN-related side effects. By intention-to-treat analysis, 14 (37%)
had a sustained virologic response with preference for those infected
by genotypes other than type 1 (43% versus 12%) and with high
transaminases levels (168 U/L versus 116 U/L). Thus, IFN and ribavirin
combination therapy led to a sustained suppression of hepatitis in one
third of hemophiliac patients resistant to conventional monotherapy.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
M. Franchini, C. Mengoli, D. Veneri, R. Mazzi, G. Lippi, and M. Cruciani
Treatment of chronic hepatitis C in haemophilic patients with interferon and ribavirin: a meta-analysis
J. Antimicrob. Chemother.,
June 1, 2008;
61(6):
1191 - 1200.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Honda, H. Toyoda, K. Hayashi, Y. Katano, M. Yano, I. Nakano, K. Yoshioka, H. Goto, K. Yamamoto, and J. Takamatsu
Ribavirin and Use of Clotting Factors in Patients With Hemophilia and Chronic Hepatitis C
JAMA,
March 9, 2005;
293(10):
1190 - 1192.
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. M. Mannucci
Ham-Wasserman Lecture : Hemophilia and Related Bleeding Disorders: A Story of Dismay and Success
Hematology,
January 1, 2002;
2002(1):
1 - 9.
[Abstract]
[Full Text]
|
|
|
|
|
