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Blood, 1 February 2002, Vol. 99, No. 3, pp. 800-805
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS
Primary cutaneous lymphomas: applicability of current
classification schemes (European Organization for Research and
Treatment of Cancer, World Health Organization) based on
clinicopathologic features observed in a large group of
patients
Regina Fink-Puches,
Paulus Zenahlik,
Barbara Bäck,
Josef Smolle,
Helmut Kerl, and
Lorenzo Cerroni
From the Department of Dermatology, University of Graz,
Austria.
Classification of primary cutaneous lymphomas (PCLs) is the subject
of ongoing controversy. Based on a series of 556 patients, the
applicability of the European Organization for Research and Treatment
of Cancer (EORTC) classification for PCLs was assessed and compared to
the proposed World Health Organization (WHO) classification of
hematologic malignancies. The large majority of patients could be
properly classified according to the scheme proposed by the EORTC.
Comparison of estimated 5-year survival for specific diagnostic categories of PCLs demonstrated nearly complete concordance of the
present results with those of the EORTC study for most of the indolent
cutaneous T-cell lymphomas and cutaneous B-cell lymphomas, whereas
differences were found for mycosis fungoides-associated follicular
mucinosis and Sezary syndrome. A few patients with newly described
entities (CD8+ epidermotropic cytotoxic T-cell lymphoma,
primary cutaneous natural killer/T-cell lymphoma) could not be
classified according to the EORTC scheme. Comparison of the EORTC with
the WHO classification showed that the EORTC scheme allows a more
precise categorization of the patients, especially for cutaneous B-cell
lymphoma. In conclusion, the study confirmed that the EORTC
classification allows a better management of patients with PCL. Small
amendments to that classification should be carried out to account for
recently described entities and to unify some of the diagnostic categories.
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