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Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 February 2002, Vol. 99, No. 3, pp. 999-1004 IMMUNOBIOLOGY CD8+ dendritic cells originate from the CD8 dendritic cell subset by a maturation process involving CD8, DEC-205, and CD24 up-regulation Gloria Martínez del Hoyo, Pilar Martín, Cristina Fernández Arias, Alvaro Rodríguez Marín, and Carlos Ardavín From the Department of Cell Biology, Faculty of Biology, Complutense University, Madrid, Spain. CD8+ and CD8 dendritic cells (DCs) have been considered as independent DC subpopulations both ontogenetically and functionally during recent years. However, it has been demonstrated that both DC subsets can be generated from a single precursor population, supporting the concept that they do not represent separate DC lineages. By using highly purified splenic CD8 DCs, which were injected intravenously and traced by means of an Ly5.1/Ly5.2 transfer system, this study shows that CD8 DCs acquired the phenotypic characteristics of CD8+ DCs, by a differentiation process involving CD8, DEC-205, and CD24 up-regulation, paralleled by the down-regulation of CD11b, F4/80, and CD4. These data demonstrate that CD8+ DCs derive from CD8 DCs, and strongly support that CD8 and CD8+ DCs represent different maturation or differentiation stages of the same DC population. Therefore, CD8+ DCs would represent the last stage of DC differentiation, playing an essential role in the induction of T-cell responses, due to their antigen-presenting potential, cross-priming ability, and capacity to secrete large amounts of key cytokines such as interferon  and interleukin-12. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? 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