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Blood, 15 February 2002, Vol. 99, No. 4, pp. 1117-1129
CHEMOKINES
Stromal cell-derived factor 1 regulates primitive
hematopoiesis by suppressing apoptosis and by promoting
G0/G1 transition in CD34+ cells:
evidence for an autocrine/paracrine mechanism
Jean-Jacques Lataillade,
Denis Clay,
Philippe Bourin,
Françis Hérodin,
Catherine Dupuy,
Claude Jasmin, and
Marie-Caroline Le Bousse-Kerdilès
From the Laboratoire d'Immunologie Cellulaire, Centre
de Transfusion Sanguine des Armées Jean Julliard, Clamart Cedex,
France; Institut National de la Santé et de la Recherche
Médicale, Unité 268, Institut André Lwoff,
Hôpital Paul Brousse, Paul Villejuif, France; Centre de Recherche
du Service de Santé des Armées, maquis du
Grésivaudant, La Tronche Cedex, France.
The stromal cell-derived factor 1 (SDF-1) chemokine has various
effects on hematopoietic cell functions. Its role in migration and
homing of hematopoietic progenitors is currently well established. Previously it was shown that SDF-1 stimulates myeloid progenitor proliferation in synergy with cytokines. Results of this study indicate
that SDF-1 alone promotes survival of purified CD34+ cells
from human unmobilized peripheral blood (PB) by counteracting apoptosis
as demonstrated by its capacity to reduce DNA fragmentation, annexin-V+ cell number, and APO2.7 detection and to
modulate bcl-2 homolog protein expression. The study demonstrates that
SDF-1, produced by sorted CD34+CD38+ cells and
over-released in response to cell damage, exerts an antiapoptotic
effect on CD34+ cells through an autocrine/paracrine
regulatory loop. SDF-1 participates in the autonomous survival of
circulating CD34+ cells and its effect required activation
of the phosphotidyl inositol 3 kinase (PI3-K)/Akt axis. Cell sorting
based on Hoechst/pyroninY fluorescences shows that SDF-1 production is
restricted to cycling CD34+ cells. SDF-1 triggers
G0 quiescent cells in G1 phase and, in synergy
with thrombopoietin or Steel factor, makes CD34+ cells
progress through S+G2/M phases of cell cycle. By assessing sorted CD34+CD38 and
CD34+CD38+ in semisolid culture, the study
demonstrates that SDF-1 promotes survival of clonogenic progenitors. In
conclusion, the results are the first to indicate a role for endogenous
SDF-1 in primitive hematopoiesis regulation as a survival and cell
cycle priming factor for circulating CD34+ cells. The
proposal is made that SDF-1 may contribute to hematopoiesis homeostasis
by participating in the autonomous survival and cycling of progenitors
under physiologic conditions and by protecting them from cell
aggression in stress situations.
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169(6):
2066 - 2074.
[Abstract]
[Full Text]
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|
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|
|
|
|
Z. Zeng, I. J. Samudio, M. Munsell, J. An, Z. Huang, E. Estey, M. Andreeff, and M. Konopleva
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3113 - 3121.
[Abstract]
[Full Text]
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|
|
|
|
|
|
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108(12):
3722 - 3729.
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|
|
|
|
|
|
|
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24(4):
936 - 948.
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|
|
|
|
|
|
|
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24(4):
1030 - 1041.
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|
|
|
|
|
|
|
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Reduced retention of radioprotective hematopoietic cells within the bone marrow microenvironment in CXCR4-/- chimeric mice
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107(6):
2243 - 2251.
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|
|
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|
|
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March 1, 2006;
107(5):
1761 - 1767.
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|
|
|
|
|
|
|
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107(5):
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|
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|
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176(4):
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|
|
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|
|
|
|
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|
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|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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|
|
|
|
|
|
|
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19(10):
1225 - 1231.
[Abstract]
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|
|
|
|
|
|
|
M. Kucia, R. Reca, K. Miekus, J. Wanzeck, W. Wojakowski, A. Janowska-Wieczorek, J. Ratajczak, and M. Z. Ratajczak
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August 1, 2005;
23(7):
879 - 894.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J.-J. Lataillade, D. Clay, C. David, L. Boutin, B. Guerton, M. Drouet, F. Herodin, and M.-C. Le Bousse-Kerdiles
Phenotypic and functional characteristics of CD34+ cells are related to their anatomical environment: is their versatility a prerequisite for their bio-availability?
J. Leukoc. Biol.,
May 1, 2005;
77(5):
634 - 643.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. J. Bendall, R. Baraz, J. Juarez, W. Shen, and K. F. Bradstock
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April 15, 2005;
65(8):
3290 - 3298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Byk, J. Kahn, O. Kollet, I. Petit, S. Samira, S. Shivtiel, H. Ben-Hur, A. Peled, W. Piacibello, and T. Lapidot
Cycling G1 CD34+/CD38+ Cells Potentiate the Motility and Engraftment of Quiescent G0 CD34+/CD38-/low Severe Combined Immunodeficiency Repopulating Cells
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April 1, 2005;
23(4):
561 - 574.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. M. Smith, P. A. Johanesen, M. K. Wendt, D. G. Binion, and M. B. Dwinell
CXCL12 activation of CXCR4 regulates mucosal host defense through stimulation of epithelial cell migration and promotion of intestinal barrier integrity
Am J Physiol Gastrointest Liver Physiol,
February 1, 2005;
288(2):
G316 - G326.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Piovan, V. Tosello, S. Indraccolo, A. Cabrelle, I. Baesso, L. Trentin, R. Zamarchi, H. Tamamura, N. Fujii, G. Semenzato, et al.
Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation
Blood,
February 1, 2005;
105(3):
931 - 939.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Jaleel, A. C. Tsai, S. Sarkar, P. V. Freedman, and L. P. Rubin
Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival
Mol. Hum. Reprod.,
December 1, 2004;
10(12):
901 - 909.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. De Falco, D. Porcelli, A. R. Torella, S. Straino, M. G. Iachininoto, A. Orlandi, S. Truffa, P. Biglioli, M. Napolitano, M. C. Capogrossi, et al.
SDF-1 involvement in endothelial phenotype and ischemia-induced recruitment of bone marrow progenitor cells
Blood,
December 1, 2004;
104(12):
3472 - 3482.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Marchesi, P. Monti, B. E. Leone, A. Zerbi, A. Vecchi, L. Piemonti, A. Mantovani, and P. Allavena
Increased Survival, Proliferation, and Migration in Metastatic Human Pancreatic Tumor Cells Expressing Functional CXCR4
Cancer Res.,
November 15, 2004;
64(22):
8420 - 8427.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Zhang, A. Foudi, J.-F. Geay, M. Berthebaud, D. Buet, P. Jarrier, A. Jalil, W. Vainchenker, and F. Louache
Intracellular Localization and Constitutive Endocytosis of CXCR4 in Human CD34+ Hematopoietic Progenitor Cells
Stem Cells,
November 1, 2004;
22(6):
1015 - 1029.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. J. C. Rombouts, B. Pavic, B. Lowenberg, and R. E. Ploemacher
Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
Blood,
July 15, 2004;
104(2):
550 - 557.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B.-C. Lee, T.-H. Lee, S. Avraham, and H. K. Avraham
Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1{alpha} in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells
Mol. Cancer Res.,
June 1, 2004;
2(6):
327 - 338.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. B. Dwinell, H. Ogawa, K. E. Barrett, and M. F. Kagnoff
SDF-1/CXCL12 regulates cAMP production and ion transport in intestinal epithelial cells via CXCR4
Am J Physiol Gastrointest Liver Physiol,
May 1, 2004;
286(5):
G844 - G850.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tavor, I. Petit, S. Porozov, A. Avigdor, A. Dar, L. Leider-Trejo, N. Shemtov, V. Deutsch, E. Naparstek, A. Nagler, et al.
CXCR4 Regulates Migration and Development of Human Acute Myelogenous Leukemia Stem Cells in Transplanted NOD/SCID Mice
Cancer Res.,
April 15, 2004;
64(8):
2817 - 2824.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Kahn, T. Byk, L. Jansson-Sjostrand, I. Petit, S. Shivtiel, A. Nagler, I. Hardan, V. Deutsch, Z. Gazit, D. Gazit, et al.
Overexpression of CXCR4 on human CD34+ progenitors increases their proliferation, migration, and NOD/SCID repopulation
Blood,
April 15, 2004;
103(8):
2942 - 2949.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. P. Chute, G. Muramoto, J. Fung, and C. Oxford
Quantitative Analysis Demonstrates Expansion of SCID-Repopulating Cells and Increased Engraftment Capacity in Human Cord Blood Following Ex Vivo Culture with Human Brain Endothelial Cells
Stem Cells,
March 1, 2004;
22(2):
202 - 215.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. G. Kayali, K. Van Gunst, I. L. Campbell, A. Stotland, M. Kritzik, G. Liu, M. Flodstrom-Tullberg, Y.-Q. Zhang, and N. Sarvetnick
The stromal cell-derived factor-1{alpha}/CXCR4 ligand-receptor axis is critical for progenitor survival and migration in the pancreas
J. Cell Biol.,
November 24, 2003;
163(4):
859 - 869.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Laakko and R. L. Juliano
Adhesion Regulation of Stromal Cell-derived Factor-1 Activation of ERK in Lymphocytes by Phosphatases
J. Biol. Chem.,
August 22, 2003;
278(34):
31621 - 31628.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tarte, F. Zhan, J. De Vos, B. Klein, and J. Shaughnessy Jr
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation
Blood,
July 15, 2003;
102(2):
592 - 600.
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