SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Smyth, M. J. Articles by Godfrey, D. I. Search for Related Content PubMed PubMed Citation Articles by Smyth, M. J. Articles by Godfrey, D. I. Related Collections Immunobiology Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 February 2002, Vol. 99, No. 4, pp. 1259-1266 IMMUNOBIOLOGY Sequential production of interferon- by NK1.1+ T cells and natural killer cells is essential for the antimetastatic effect of -galactosylceramide Mark J. Smyth, Nadine Y. Crowe, Daniel G. Pellicci, Konstantinos Kyparissoudis, Janice M. Kelly, Kazuyoshi Takeda, Hideo Yagita, and Dale I. Godfrey From Cancer Immunology, Trescowthick Laboratories, Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia; the Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia; and the Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan. The antimetastatic effect of the CD1d-binding glycolipid, -galactosylceramide (-GalCer), is mediated by NK1.1+T (NKT) cells; however, the mechanisms behind this process are poorly defined. Although it has been shown to involve NK cells and interferon- (IFN-) production, the way these factors collaborate to mediate effective tumor rejection and the importance of other factors characteristic of NKT cell and NK cell activation are unknown. Using gene-targeted mice and antibody treatments, the critical need for interleukin 12 (IL-12), IFN-, and NK cells has been shown in the antimetastatic activity of -GalCer in the lungs and the liver. By contrast, in lung and liver metastasis models, cytotoxic molecules expressed by NK cells and NKT cells (perforin, Fas ligand, and tumor necrosis factor-related apoptosis-inducing ligand) and an NKT cell-secreted cytokine, IL-4, were not necessary for the antitumor activity of -GalCer. Like IL-12, IL-18 was required for optimal serum IFN- induction and control of lung metastases by -GalCer. IL-18 was unnecessary for -GalCer-related suppression of liver metastases. Most importantly, after adoptive transfer of -GalCer-reactive NKT cells or NK cells into NKT cell-deficient, IFN--deficient, or RAG-1-deficient mice, it was demonstrated that the sequential production of IFN- by NKT cells and NK cells was absolutely required to reconstitute the antimetastatic activity of -GalCer. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: H. Sondergaard, J. M. Coquet, A. P. Uldrich, N. McLaughlin, D. I. Godfrey, P. V. Sivakumar, K. Skak, and M. J. Smyth Endogenous IL-21 Restricts CD8+ T Cell Expansion and Is not Required for Tumor Immunity J. Immunol., December 1, 2009; 183(11): 7326 - 7336. [Abstract] [Full Text] [PDF] R. Cullen, E. Germanov, T. Shimaoka, and B. Johnston Enhanced Tumor Metastasis in Response to Blockade of the Chemokine Receptor CXCR6 Is Overcome by NKT Cell Activation J. Immunol., November 1, 2009; 183(9): 5807 - 5815. [Abstract] [Full Text] [PDF] H. Yuling, X. Ruijing, L. Li, J. Xiang, Z. Rui, W. Yujuan, Z. Lijun, D. Chunxian, T. Xinti, X. Wei, et al. EBV-Induced Human CD8+ NKT Cells Suppress Tumorigenesis by EBV-Associated Malignancies Cancer Res., October 15, 2009; 69(20): 7935 - 7944. [Abstract] [Full Text] [PDF] R. Starr, M. Fuchsberger, L. S. Lau, A. P. Uldrich, A. Goradia, T. A. Willson, A. M. Verhagen, W. S. Alexander, and M. J. Smyth SOCS-1 Binding to Tyrosine 441 of IFN-{gamma} Receptor Subunit 1 Contributes to the Attenuation of IFN-{gamma} Signaling In Vivo J. Immunol., October 1, 2009; 183(7): 4537 - 4544. [Abstract] [Full Text] [PDF] E. A. Haddad, L. K. Senger, and F. Takei An Accessory Role for B Cells in the IL-12-Induced Activation of Resting Mouse NK Cells J. Immunol., September 15, 2009; 183(6): 3608 - 3615. [Abstract] [Full Text] [PDF] M. W. L. Teng, J. Sharkey, N. M. McLaughlin, M. A. Exley, and M. J. Smyth CD1d-Based Combination Therapy Eradicates Established Tumors in Mice J. Immunol., August 1, 2009; 183(3): 1911 - 1920. [Abstract] [Full Text] [PDF] Y. Uemura, T.-Y. Liu, Y. Narita, M. Suzuki, R. Nakatsuka, T. Araki, M. Matsumoto, L. K. Iwai, N. Hirosawa, Y. Matsuoka, et al. Cytokine-Dependent Modification of IL-12p70 and IL-23 Balance in Dendritic Cells by Ligand Activation of V{alpha}24 Invariant NKT Cells J. Immunol., July 1, 2009; 183(1): 201 - 208. [Abstract] [Full Text] [PDF] C.-H. Lee, Y.-H. Chiang, S.-E. Chang, C.-L. Chong, B.-M. Cheng, and S. R. Roffler Tumor-Localized Ligation of CD3 and CD28 with Systemic Regulatory T-Cell Depletion Induces Potent Innate and Adaptive Antitumor Responses Clin. Cancer Res., April 15, 2009; 15(8): 2756 - 2766. [Abstract] [Full Text] [PDF] V. V. Parekh, S. Lalani, S. Kim, R. Halder, M. Azuma, H. Yagita, V. Kumar, L. Wu, and L. Van Kaer PD-1/PD-L Blockade Prevents Anergy Induction and Enhances the Anti-Tumor Activities of Glycolipid-Activated Invariant NKT Cells J. Immunol., March 1, 2009; 182(5): 2816 - 2826. [Abstract] [Full Text] [PDF] S. Motohashi, K. Nagato, N. Kunii, H. Yamamoto, K. Yamasaki, K. Okita, H. Hanaoka, N. Shimizu, M. Suzuki, I. Yoshino, et al. A Phase I-II Study of {alpha}-Galactosylceramide-Pulsed IL-2/GM-CSF-Cultured Peripheral Blood Mononuclear Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer J. Immunol., February 15, 2009; 182(4): 2492 - 2501. [Abstract] [Full Text] [PDF] W.-S. Chang, J.-Y. Kim, Y.-J. Kim, Y.-S. Kim, J.-M. Lee, M. Azuma, H. Yagita, and C.-Y. Kang Cutting Edge: Programmed Death-1/Programmed Death Ligand 1 Interaction Regulates the Induction and Maintenance of Invariant NKT Cell Anergy J. Immunol., November 15, 2008; 181(10): 6707 - 6710. [Abstract] [Full Text] [PDF] W. Song, H. J.J. van der Vliet, Y.-T. Tai, R. Prabhala, R. Wang, K. Podar, L. Catley, M. A. Shammas, K. C. Anderson, S. P. Balk, et al. Generation of Antitumor Invariant Natural Killer T Cell Lines in Multiple Myeloma and Promotion of Their Functions via Lenalidomide: A Strategy for Immunotherapy Clin. Cancer Res., November 1, 2008; 14(21): 6955 - 6962. [Abstract] [Full Text] [PDF] G. Sireci, M. P. La Manna, D. Di Liberto, M. Lo Dico, M. Taniguchi, F. Dieli, and A. Salerno Prophylaxis of lipopolysaccharide-induced shock by {alpha}-galactosylceramide J. Leukoc. Biol., August 1, 2008; 84(2): 550 - 560. [Abstract] [Full Text] [PDF] M. B. F. Werneck, G. Lugo-Villarino, E. S. Hwang, H. Cantor, and L. H. Glimcher T-Bet Plays a Key Role in NK-Mediated Control of Melanoma Metastatic Disease J. Immunol., June 15, 2008; 180(12): 8004 - 8010. [Abstract] [Full Text] [PDF] J. A. Berzofsky and M. Terabe NKT Cells in Tumor Immunity: Opposing Subsets Define a New Immunoregulatory Axis J. Immunol., March 15, 2008; 180(6): 3627 - 3635. [Abstract] [Full Text] [PDF] D. Torres, C. Paget, J. Fontaine, T. Mallevaey, T. Matsuoka, T. Maruyama, S. Narumiya, M. Capron, P. Gosset, C. Faveeuw, et al. Prostaglandin D2 Inhibits the Production of IFN-{gamma} by Invariant NK T Cells: Consequences in the Control of B16 Melanoma J. Immunol., January 15, 2008; 180(2): 783 - 792. [Abstract] [Full Text] [PDF] N. Hyka-Nouspikel, L. Lucian, E. Murphy, T. McClanahan, and J. H. Phillips DAP10 Deficiency Breaks the Immune Tolerance against Transplantable Syngeneic Melanoma J. Immunol., September 15, 2007; 179(6): 3763 - 3771. [Abstract] [Full Text] [PDF] M. W.L. Teng, J. A. Westwood, P. K. Darcy, J. Sharkey, M. Tsuji, R. W. Franck, S. A. Porcelli, G. S. Besra, K. Takeda, H. Yagita, et al. Combined Natural Killer T-Cell Based Immunotherapy Eradicates Established Tumors in Mice Cancer Res., August 1, 2007; 67(15): 7495 - 7504. [Abstract] [Full Text] [PDF] M. N. Ajuebor, Z. Wondimu, C. M. Hogaboam, T. Le, A. E.I. Proudfoot, and M. G. Swain CCR5 Deficiency Drives Enhanced Natural Killer Cell Trafficking to and Activation within the Liver in Murine T Cell-Mediated Hepatitis Am. J. Pathol., June 1, 2007; 170(6): 1975 - 1988. [Abstract] [Full Text] [PDF] J. Okajo, Y. Kaneko, Y. Murata, T. Tomizawa, C. Okuzawa, Y. Saito, Y. Kaneko, T. Ishikawa-Sekigami, H. Okazawa, H. Ohnishi, et al. Regulation by Src Homology 2 Domain-Containing Protein Tyrosine Phosphatase Substrate-1 of {alpha}-Galactosylceramide-Induced Antimetastatic Activity and Th1 and Th2 Responses of NKT Cells J. Immunol., May 15, 2007; 178(10): 6164 - 6172. [Abstract] [Full Text] [PDF] R. Zhu, S. Diem, L. M. Araujo, A. Aumeunier, J. Denizeau, E. Philadelphe, D. Damotte, M. Samson, P. Gourdy, M. Dy, et al. The Pro-Th1 Cytokine IL-12 Enhances IL-4 Production by Invariant NKT Cells: Relevance for T Cell-Mediated Hepatitis J. Immunol., May 1, 2007; 178(9): 5435 - 5442. [Abstract] [Full Text] [PDF] H. Kishimoto, T. Ohteki, N. Yajima, K. Kawahara, M. Natsui, S. Kawarasaki, K. Hamada, Y. Horie, Y. Kubo, S. Arase, et al. The Pten/PI3K pathway governs the homeostasis of V{alpha}14iNKT cells Blood, April 15, 2007; 109(8): 3316 - 3324. [Abstract] [Full Text] [PDF] G. Sireci, M. P. La Manna, C. Di Sano, D. Di Liberto, S. A. Porcelli, M. Kronenberg, F. Dieli, and A. Salerno Pivotal Advance: {alpha}-Galactosylceramide induces protection against lipopolysaccharide-induced shock J. Leukoc. Biol., March 1, 2007; 81(3): 607 - 622. [Abstract] [Full Text] [PDF] N. A. Nagarajan and M. Kronenberg Invariant NKT Cells Amplify the Innate Immune Response to Lipopolysaccharide J. Immunol., March 1, 2007; 178(5): 2706 - 2713. [Abstract] [Full Text] [PDF] R. Keating, W. Yue, J. A. Rutigliano, J. So, E. Olivas, P. G. Thomas, and P. C. Doherty Virus-Specific CD8+ T Cells in the Liver: Armed and Ready to Kill J. Immunol., March 1, 2007; 178(5): 2737 - 2745. [Abstract] [Full Text] [PDF] J. M. Coquet, K. Kyparissoudis, D. G. Pellicci, G. Besra, S. P. Berzins, M. J. Smyth, and D. I. Godfrey IL-21 Is Produced by NKT Cells and Modulates NKT Cell Activation and Cytokine Production J. Immunol., March 1, 2007; 178(5): 2827 - 2834. [Abstract] [Full Text] [PDF] K. Shimizu, A. Goto, M. Fukui, M. Taniguchi, and S.-i. Fujii Tumor Cells Loaded with {alpha}-Galactosylceramide Induce Innate NKT and NK Cell-Dependent Resistance to Tumor Implantation in Mice J. Immunol., March 1, 2007; 178(5): 2853 - 2861. [Abstract] [Full Text] [PDF] C. Hong, H. Lee, M. Oh, C.-Y. Kang, S. Hong, and S.-H. Park CD4+ T Cells in the Absence of the CD8+ Cytotoxic T Cells Are Critical and Sufficient for NKT Cell-Dependent Tumor Rejection J. Immunol., November 15, 2006; 177(10): 6747 - 6757. [Abstract] [Full Text] [PDF] S. Motohashi, A. Ishikawa, E. Ishikawa, M. Otsuji, T. Iizasa, H. Hanaoka, N. Shimizu, S. Horiguchi, Y. Okamoto, S.-i. Fujii, et al. A Phase I Study of In vitro Expanded Natural Killer T Cells in Patients with Advanced and Recurrent Non-Small Cell Lung Cancer Clin. Cancer Res., October 15, 2006; 12(20): 6079 - 6086. [Abstract] [Full Text] [PDF] G. Lizee, L. G. Radvanyi, W. W. Overwijk, and P. Hwu Improving Antitumor Immune Responses by Circumventing Immunoregulatory Cells and Mechanisms. Clin. Cancer Res., August 15, 2006; 12(16): 4794 - 4803. [Abstract] [Full Text] [PDF] C. J. Montoya, H.-B. Jie, L. Al-Harthi, C. Mulder, P. J. Patino, M. T. Rugeles, A. M. Krieg, A. L. Landay, and S. B. Wilson Activation of Plasmacytoid Dendritic Cells with TLR9 Agonists Initiates Invariant NKT Cell-Mediated Cross-Talk with Myeloid Dendritic Cells J. Immunol., July 15, 2006; 177(2): 1028 - 1039. [Abstract] [Full Text] [PDF] D. H. Chang, N. Liu, V. Klimek, H. Hassoun, A. Mazumder, S. D. Nimer, S. Jagannath, and M. V. Dhodapkar Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications Blood, July 15, 2006; 108(2): 618 - 621. [Abstract] [Full Text] [PDF] Y. Chung, B.-S. Kim, Y.-J. Kim, H.-J. Ko, S.-Y. Ko, D.-H. Kim, and C.-Y. Kang CD1d-Restricted T Cells License B Cells to Generate Long-Lasting Cytotoxic Antitumor Immunity In vivo. Cancer Res., July 1, 2006; 66(13): 6843 - 6850. [Abstract] [Full Text] [PDF] M. J. Smyth, M. W. L. Teng, J. Swann, K. Kyparissoudis, D. I. Godfrey, and Y. Hayakawa CD4+CD25+ T Regulatory Cells Suppress NK Cell-Mediated Immunotherapy of Cancer J. Immunol., February 1, 2006; 176(3): 1582 - 1587. [Abstract] [Full Text] [PDF] K.-i. Seino and M. Taniguchi Functionally distinct NKT cell subsets and subtypes J. Exp. Med., December 19, 2005; 202(12): 1623 - 1626. [Abstract] [Full Text] [PDF] S. Oki, C. Tomi, T. Yamamura, and S. Miyake Preferential Th2 polarization by OCH is supported by incompetent NKT cell induction of CD40L and following production of inflammatory cytokines by bystander cells in vivo Int. Immunol., December 1, 2005; 17(12): 1619 - 1629. [Abstract] [Full Text] [PDF] N. Y. Crowe, J. M. Coquet, S. P. Berzins, K. Kyparissoudis, R. Keating, D. G. Pellicci, Y. Hayakawa, D. I. Godfrey, and M. J. Smyth Differential antitumor immunity mediated by NKT cell subsets in vivo J. Exp. Med., November 7, 2005; 202(9): 1279 - 1288. [Abstract] [Full Text] [PDF] M. Svensson, S. Zubairi, A. Maroof, F. Kazi, M. Taniguchi, and P. M. Kaye Invariant NKT Cells Are Essential for the Regulation of Hepatic CXCL10 Gene Expression during Leishmania donovani Infection Infect. Immun., November 1, 2005; 73(11): 7541 - 7547. [Abstract] [Full Text] [PDF] Y. Yasunami, S. Kojo, H. Kitamura, A. Toyofuku, M. Satoh, M. Nakano, K. Nabeyama, Y. Nakamura, N. Matsuoka, S. Ikeda, et al. V{alpha}14 NK T cell-triggered IFN-{gamma} production by Gr-1+CD11b+ cells mediates early graft loss of syngeneic transplanted islets J. Exp. Med., October 3, 2005; 202(7): 913 - 918. [Abstract] [Full Text] [PDF] A. P. Uldrich, N. Y. Crowe, K. Kyparissoudis, D. G. Pellicci, Y. Zhan, A. M. Lew, P. Bouillet, A. Strasser, M. J. Smyth, and D. I. Godfrey NKT Cell Stimulation with Glycolipid Antigen In Vivo: Costimulation-Dependent Expansion, Bim-Dependent Contraction, and Hyporesponsiveness to Further Antigenic Challenge J. Immunol., September 1, 2005; 175(5): 3092 - 3101. [Abstract] [Full Text] [PDF] T. Osada, M. A. Morse, H. K. Lyerly, and T. M. Clay Ex vivo expanded human CD4+ regulatory NKT cells suppress expansion of tumor antigen-specific CTLs Int. Immunol., September 1, 2005; 17(9): 1143 - 1155. [Abstract] [Full Text] [PDF] K. Minami, Y. Yanagawa, K. Iwabuchi, N. Shinohara, T. Harabayashi, K. Nonomura, and K. Onoe Negative feedback regulation of T helper type 1 (Th1)/Th2 cytokine balance via dendritic cell and natural killer T cell interactions Blood, September 1, 2005; 106(5): 1685 - 1693. [Abstract] [Full Text] [PDF] K. Haraguchi, T. Takahashi, A. Matsumoto, T. Asai, Y. Kanda, M. Kurokawa, S. Ogawa, H. Oda, M. Taniguchi, H. Hirai, et al. Host-Residual Invariant NK T Cells Attenuate Graft-versus-Host Immunity J. Immunol., July 15, 2005; 175(2): 1320 - 1328. [Abstract] [Full Text] [PDF] H. Matsuda, T. Suda, J. Sato, T. Nagata, Y. Koide, K. Chida, and H. Nakamura {alpha}-Galactosylceramide, a Ligand of Natural Killer T Cells, Inhibits Allergic Airway Inflammation Am. J. Respir. Cell Mol. Biol., July 1, 2005; 33(1): 22 - 31. [Abstract] [Full Text] [PDF] M. J. Smyth, M. E. Wallace, S. L. Nutt, H. Yagita, D. I. Godfrey, and Y. Hayakawa Sequential activation of NKT cells and NK cells provides effective innate immunotherapy of cancer J. Exp. Med., June 20, 2005; 201(12): 1973 - 1985. [Abstract] [Full Text] [PDF] R. Wessely Interference by interferons: Janus faces in vascular proliferative diseases Cardiovasc Res, June 1, 2005; 66(3): 433 - 443. [Abstract] [Full Text] [PDF] D. H. Chang, K. Osman, J. Connolly, A. Kukreja, J. Krasovsky, M. Pack, A. Hutchinson, M. Geller, N. Liu, R. Annable, et al. Sustained expansion of NKT cells and antigen-specific T cells after injection of {alpha}-galactosyl-ceramide loaded mature dendritic cells in cancer patients J. Exp. Med., May 2, 2005; 201(9): 1503 - 1517. [Abstract] [Full Text] [PDF] M. S. Duthie and S. J. Kahn NK cell activation and protection occur independently of natural killer T cells during Trypanosoma cruzi infection Int. Immunol., May 1, 2005; 17(5): 607 - 613. [Abstract] [Full Text] [PDF] J. D. Wesley, S. H. Robbins, S. Sidobre, M. Kronenberg, S. Terrizzi, and L. Brossay Cutting Edge: IFN-{gamma} Signaling to Macrophages Is Required for Optimal V{alpha}14i NK T/NK Cell Cross-Talk J. Immunol., April 1, 2005; 174(7): 3864 - 3868. [Abstract] [Full Text] [PDF] M. J. Smyth, J. Swann, J. M. Kelly, E. Cretney, W. M. Yokoyama, A. Diefenbach, T. J. Sayers, and Y. Hayakawa NKG2D Recognition and Perforin Effector Function Mediate Effective Cytokine Immunotherapy of Cancer J. Exp. Med., November 15, 2004; 200(10): 1325 - 1335. [Abstract] [Full Text] [PDF] F. Granucci, I. Zanoni, N. Pavelka, S. L.H. van Dommelen, C. E. Andoniou, F. Belardelli, M. A. Degli Esposti, and P. Ricciardi-Castagnoli A Contribution of Mouse Dendritic Cell-Derived IL-2 for NK Cell Activation J. Exp. Med., August 2, 2004; 200(3): 287 - 295. [Abstract] [Full Text] [PDF] E. Durante-Mangoni, R. Wang, A. Shaulov, Q. He, I. Nasser, N. Afdhal, M. J. Koziel, and M. A. Exley Hepatic CD1d Expression in Hepatitis C Virus Infection and Recognition by Resident Proinflammatory CD1d-Reactive T Cells J. Immunol., August 1, 2004; 173(3): 2159 - 2166. [Abstract] [Full Text] [PDF] M. Maeda, A. Shadeo, A. M. MacFadyen, and F. Takei CD1d-Independent NKT Cells in {beta}2-Microglobulin-Deficient Mice Have Hybrid Phenotype and Function of NK and T Cells J. Immunol., May 15, 2004; 172(10): 6115 - 6122. [Abstract] [Full Text] [PDF] L. S. Metelitsa, H.-W. Wu, H. Wang, Y. Yang, Z. Warsi, S. Asgharzadeh, S. Groshen, S. B. Wilson, and R. C. Seeger Natural Killer T Cells Infiltrate Neuroblastomas Expressing the Chemokine CCL2 J. Exp. Med., May 3, 2004; 199(9): 1213 - 1221. [Abstract] [Full Text] [PDF] J. Brady, Y. Hayakawa, M. J. Smyth, and S. L. Nutt IL-21 Induces the Functional Maturation of Murine NK Cells J. Immunol., February 15, 2004; 172(4): 2048 - 2058. [Abstract] [Full Text] [PDF] J. R. Ortaldo, H. A. Young, R. T. Winkler-Pickett, E. W. Bere Jr., W. J. Murphy, and R. H. Wiltrout Dissociation of NKT Stimulation, Cytokine Induction, and NK Activation In Vivo by the Use of Distinct TCR-Binding Ceramides J. Immunol., January 15, 2004; 172(2): 943 - 953. [Abstract] [Full Text] [PDF] M. Nieda, M. Okai, A. Tazbirkova, H. Lin, A. Yamaura, K. Ide, R. Abraham, T. Juji, D. J. Macfarlane, and A. J. Nicol Therapeutic activation of V{alpha}24+V{beta}11+ NKT cells in human subjects results in highly coordinated secondary activation of acquired and innate immunity Blood, January 15, 2004; 103(2): 383 - 389. [Abstract] [Full Text] [PDF] O. Shibolet, Y. Kalish, A. Klein, R. Alper, L. Zolotarov, B. Thalenfeld, D. Engelhardt, E. Rabbani, and Y. Ilan Adoptive transfer of ex vivo immune-programmed NKT lymphocytes alleviates immune-mediated colitis J. Leukoc. Biol., January 1, 2004; 75(1): 76 - 86. [Abstract] [Full Text] [PDF] J. Schmieg, G. Yang, R. W. Franck, and M. Tsuji Superior Protection against Malaria and Melanoma Metastases by a C-glycoside Analogue of the Natural Killer T Cell Ligand {alpha}-Galactosylceramide J. Exp. Med., December 1, 2003; 198(11): 1631 - 1641. [Abstract] [Full Text] [PDF] N. Y. Crowe, A. P. Uldrich, K. Kyparissoudis, K. J. L. Hammond, Y. Hayakawa, S. Sidobre, R. Keating, M. Kronenberg, M. J. Smyth, and D. I. Godfrey Glycolipid Antigen Drives Rapid Expansion and Sustained Cytokine Production by NK T Cells J. Immunol., October 15, 2003; 171(8): 4020 - 4027. [Abstract] [Full Text] [PDF] A. A. Ashkar and K. L. Rosenthal Interleukin-15 and Natural Killer and NKT Cells Play a Critical Role in Innate Protection against Genital Herpes Simplex Virus Type 2 Infection J. Virol., September 15, 2003; 77(18): 10168 - 10171. [Abstract] [Full Text] [PDF] L. M. Esteban, T. Tsoutsman, M. A. Jordan, D. Roach, L. D. Poulton, A. Brooks, O. V. Naidenko, S. Sidobre, D. I. Godfrey, and A. G. Baxter Genetic Control of NKT Cell Numbers Maps to Major Diabetes and Lupus Loci J. Immunol., September 15, 2003; 171(6): 2873 - 2878. [Abstract] [Full Text] [PDF] C. N. Baxevanis, A. D. Gritzapis, and M. Papamichail In Vivo Antitumor Activity of NKT Cells Activated by the Combination of IL-12 and IL-18 J. Immunol., September 15, 2003; 171(6): 2953 - 2959. [Abstract] [Full Text] [PDF] Y. Hayakawa, S. Rovero, G. Forni, and M. J. Smyth {alpha}-Galactosylceramide (KRN7000) suppression of chemical- and oncogene-dependent carcinogenesis PNAS, August 5, 2003; 100(16): 9464 - 9469. [Abstract] [Full Text] [PDF] M. J. Smyth, S. E. A. Street, and J. A. Trapani Cutting Edge: Granzymes A and B Are Not Essential for Perforin-Mediated Tumor Rejection J. Immunol., July 15, 2003; 171(2): 515 - 518. [Abstract] [Full Text] [PDF] H.-L. Ma, M. J. Whitters, R. F. Konz, M. Senices, D. A. Young, M. J. Grusby, M. Collins, and K. Dunussi-Joannopoulos IL-21 Activates Both Innate and Adaptive Immunity to Generate Potent Antitumor Responses that Require Perforin but Are Independent of IFN-{gamma} J. Immunol., July 15, 2003; 171(2): 608 - 615. [Abstract] [Full Text] [PDF] Y. Miyahira, M. Katae, K. Takeda, H. Yagita, K. Okumura, S. Kobayashi, T. Takeuchi, T. Kamiyama, Y. Fukuchi, and T. Aoki Activation of Natural Killer T Cells by {alpha}-Galactosylceramide Impairs DNA Vaccine-Induced Protective Immunity against Trypanosoma cruzi Infect. Immun., March 1, 2003; 71(3): 1234 - 1241. [Abstract] [Full Text] [PDF] S. L. H. van Dommelen, H. A. Tabarias, M. J. Smyth, and M. A. Degli-Esposti Activation of Natural Killer (NK) T Cells during Murine Cytomegalovirus Infection Enhances the Antiviral Response Mediated by NK Cells J. Virol., February 1, 2003; 77(3): 1877 - 1884. [Abstract] [Full Text] [PDF] N. Y. Crowe, M. J. Smyth, and D. I. Godfrey A Critical Role for Natural Killer T Cells in Immunosurveillance of Methylcholanthrene-induced Sarcomas J. Exp. Med., July 1, 2002; 196(1): 119 - 127. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020