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Blood, 15 February 2002, Vol. 99, No. 4, pp. 1282-1288
IMMUNOBIOLOGY
Dramatic increase in lymph node dendritic cell number during
infection by the mouse mammary tumor virus occurs by a
CD62L-dependent blood-borne DC recruitment
Pilar Martín,
Sara
Ruiz Ruiz,
Gloria Martínez del Hoyo,
Fabienne Anjuère,
Héctor
Hernández Vargas,
María López-Bravo, and
Carlos Ardavín
From the Department of Cell Biology, Faculty of
Biology, Complutense University, Madrid, Spain.
Despite the information dealing with the differential phenotype and
function of the main mouse dendritic cell (DC) subpopulations, namely,
CD8  and CD8+ DCs, their origin and
involvement in antiviral immune responses in vivo are still largely
unknown. To address these issues, this study used the changes occurring
in DC subpopulations during the experimental infection by the Swiss
(SW) strain of the mouse mammary tumor virus (MMTV). MMTV(SW) induced
an 18-fold increase in lymph node DCs, which can be blocked by
anti-CD62L treatment, concomitant with the presence of high numbers of
DCs in the outer cortex, in close association with high endothelial
venules. These data suggest that the DC increase caused by MMTV(SW)
infection results from the recruitment of blood-borne DCs via high
endothelial venules, by a CD62L-dependent mechanism. In addition, skin
sensitization assays indicate that MMTV(SW) infection inhibits
epidermal Langerhans cell migration to the draining lymph node.
Moreover, data on the kinetics of MMTV(SW)-induced expansion of the
different DC subsets support the hypothesis that CD8 and
CD8+ DCs represent different maturation stages of the same
DC population, rather than myeloid- and lymphoid-derived DCs,
respectively, as previously proposed. Finally, the fact that DCs were
infected by MMTV(SW) suggests their participation in the early phases
of infection.
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