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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Gombart, A. F. Articles by Koeffler, H. P. Search for Related Content PubMed PubMed Citation Articles by Gombart, A. F. Articles by Koeffler, H. P. Related Collections Neoplasia Gene Expression Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 February 2002, Vol. 99, No. 4, pp. 1332-1340 NEOPLASIA Mutations in the gene encoding the transcription factor CCAAT/enhancer binding protein  in myelodysplastic syndromes and acute myeloid leukemias Adrian F. Gombart, Wolf-K. Hofmann, Seiji Kawano, Seisho Takeuchi, Utz Krug, Scott H. Kwok, Renee J. Larsen, Hiroya Asou, Carl W. Miller, Dieter Hoelzer, and H. Phillip Koeffler From Cedars-Sinai Medical Center, Burns and Allen Research Institute, Division of Hematology/Oncology, University of California-Los Angeles School of Medicine; Division of Hematology and Clinical Laboratories, Keio University School of Medicine, Tokyo, Japan; and Department of Hematology, University Hospital, Frankfurt am Main, Germany. The CCAAT/enhancer binding protein  (C/EBP) protein is essential for proper lung and liver function and granulocytic and adipose tissue differentation. It was hypothesized that abnormalties in C/EBP function contribute to the development of malignancies in a variety of tissues. To test this, genomic DNA from 408 patient samples and 5 cell lines representing 11 different cancers was screened for mutations in the C/EBP gene. Two silent polymorphisms termed P1 and P2 were present at frequencies of 13.5% and 2.2%, respectively. Of the12 mutations detected in 10 patients, silent changes were identified in one nonsmall cell lung cancer, one prostate cancer, and one acute myelogenous leukemia (AML) subtype M4. The 9 remaining mutations were detected in 1 of 92 (1.1%) myelodysplastic syndrome (MDS) samples and 6 of 78 (7.7%) AML (AML-M2 and AML-M4) samples. Some mutations truncated the predicted protein with loss of the DNA-binding (basic region) and dimerization (leucine zipper [ZIP]) domains by either deletions or nonsense codons. Also, inframe deletions or insertions in the fork region located between the leucine zipper and basic region, or within the leucine zipper, disrupted the -helical phase of the bZIP domain. The inframe deletion and insertion mutations abrogated the transcriptional activation function of C/EBP on the granulocyte colony-stimulating factor receptor promoter. These mutants localized properly to the nucleus, but were unable to bind to the C/EBP site in the promoter and did not possess dominant-negative activity. The mutations in the MDS patient and one AML-M2 patient were biallelic, indicating a loss of C/EBP function. These results suggest that mutation of C/EBP is involved in specific subtypes of AML and in MDS, but may occur rarely in other types of leukemias or nonhematologic malignancies. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: T. Pabst and B. U. Mueller Complexity of CEBPA Dysregulation in Human Acute Myeloid Leukemia Clin. Cancer Res., September 1, 2009; 15(17): 5303 - 5307. [Abstract] [Full Text] [PDF] C. R. Geest, M. Buitenhuis, E. Vellenga, and P. J. 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