|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 February 2002, Vol. 99, No. 4, pp. 1405-1410
NEOPLASIA
Cell surface proteoglycan syndecan-1 mediates hepatocyte growth
factor binding and promotes Met signaling in multiple myeloma
Patrick W. B. Derksen,
Robert M. J. Keehnen,
Ludo M. Evers,
Marinus H. J. van
Oers,
Marcel Spaargaren, and
Steven T. Pals
From the Department of Pathology and the Department of
Hematology, Academic Medical Center, University of Amsterdam, The
Netherlands.
Heparan sulfate proteoglycans (HSPGs) play a crucial role in growth
regulation by assembling signaling complexes and presenting growth
factors to their cognate receptors. Within the immune system, expression of the HSPG syndecan-1 (CD138) is characteristic of terminally differentiated B cells, ie, plasma cells, and their malignant counterpart, multiple myeloma (MM). This study explored the
hypothesis that syndecan-1 might promote growth factor signaling and
tumor growth in MM. For this purpose, the interaction was studied
between syndecan-1 and hepatocyte growth factor (HGF), a putative
paracrine and autocrine regulator of MM growth. The study demonstrates
that syndecan-1 is capable of binding HGF and that this growth factor
is indeed a potent stimulator of MM survival and proliferation.
Importantly, the interaction of HGF with heparan sulfate moieties on
syndecan-1 strongly promotes HGF-mediated signaling, resulting in
enhanced activation of Met, the receptor tyrosine kinase for HGF.
Moreover, HGF binding to syndecan-1 promotes activation of the
phosphatidylinositol 3-kinase/protein kinase B and
RAS/mitogen-activated protein kinase pathways, signaling routes that
have been implicated in the regulation of cell survival and
proliferation, respectively. These results identify syndecan-1 as a
functional coreceptor for HGF that promotes HGF/Met signaling in MM
cells, thus suggesting a novel function for syndecan-1 in MM tumorigenesis.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
H. Rozemuller, E. van der Spek, L. H. Bogers-Boer, M. C. Zwart, V. Verweij, M. Emmelot, R. W. Groen, R. Spaapen, A. C. Bloem, H. M. Lokhorst, et al.
A bioluminescence imaging based in vivo model for preclinical testing of novel cellular immunotherapy strategies to improve the graft-versus-myeloma effect
Haematologica,
July 1, 2008;
93(7):
1049 - 1057.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. U. Holt, U.-M. Fagerli, V. Baykov, T. B. Ro, H. Hov, A. Waage, A. Sundan, and M. Borset
Hepatocyte growth factor promotes migration of human myeloma cells
Haematologica,
April 1, 2008;
93(4):
619 - 622.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. W. A. M. Celie, R. M. Reijmers, E. M. Slot, R. H. J. Beelen, M. Spaargaren, P. M. ter Wee, S. Florquin, and J. van den Born
Tubulointerstitial heparan sulfate proteoglycan changes in human renal diseases correlate with leukocyte influx and proteinuria
Am J Physiol Renal Physiol,
January 1, 2008;
294(1):
F253 - F263.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mahtouk, D. Hose, J. De Vos, J. Moreaux, M. Jourdan, J. F. Rossi, T. Reme, H. Goldschmidt, and B. Klein
Input of DNA Microarrays to Identify Novel Mechanisms in Multiple Myeloma Biology and Therapeutic Applications
Clin. Cancer Res.,
December 15, 2007;
13(24):
7289 - 7295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sutton, V. Friand, D. Papy-Garcia, M. Dagouassat, L. Martin, R. Vassy, O. Haddad, O. Sainte-Catherine, M. Kraemer, L. Saffar, et al.
Glycosaminoglycans and their synthetic mimetics inhibit RANTES-induced migration and invasion of human hepatoma cells
Mol. Cancer Ther.,
November 1, 2007;
6(11):
2948 - 2958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. M. Stellrecht, C. J. Phillip, F. Cervantes-Gomez, and V. Gandhi
Multiple Myeloma Cell Killing by Depletion of the MET Receptor Tyrosine Kinase
Cancer Res.,
October 15, 2007;
67(20):
9913 - 9920.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Munesue, Y. Yoshitomi, Y. Kusano, Y. Koyama, A. Nishiyama, H. Nakanishi, K. Miyazaki, T. Ishimaru, S. Miyaura, M. Okayama, et al.
A Novel Function of Syndecan-2, Suppression of Matrix Metalloproteinase-2 Activation, Which Causes Suppression of Metastasis
J. Biol. Chem.,
September 21, 2007;
282(38):
28164 - 28174.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yang, V. MacLeod, Y. Dai, Y. Khotskaya-Sample, Z. Shriver, G. Venkataraman, R. Sasisekharan, A. Naggi, G. Torri, B. Casu, et al.
The syndecan-1 heparan sulfate proteoglycan is a viable target for myeloma therapy
Blood,
September 15, 2007;
110(6):
2041 - 2048.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Chen, M. S. Gordon, R. A. Campbell, M. Li, C. S. Wang, H. J. Lee, E. Sanchez, S. J. Manyak, D. Gui, D. Shalitin, et al.
Pleiotrophin is highly expressed by myeloma cells and promotes myeloma tumor growth
Blood,
July 1, 2007;
110(1):
287 - 295.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Moreaux, D. Hose, M. Jourdan, T. Reme, M. Hundemer, M. Moos, N. Robert, P. Moine, J. De Vos, H. Goldschmidt, et al.
TACI expression is associated with a mature bone marrow plasma cell signature and C-MAF overexpression in human myeloma cell lines
Haematologica,
June 1, 2007;
92(6):
803 - 811.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Mahtouk, D. Hose, P. Raynaud, M. Hundemer, M. Jourdan, E. Jourdan, V. Pantesco, M. Baudard, J. De Vos, M. Larroque, et al.
Heparanase influences expression and shedding of syndecan-1, and its expression by the bone marrow environment is a bad prognostic factor in multiple myeloma
Blood,
June 1, 2007;
109(11):
4914 - 4923.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. Pakula, A. Melchior, A. Denys, C. Vanpouille, J. Mazurier, and F. Allain
Syndecan-1/CD147 association is essential for cyclophilin B-induced activation of p44/42 mitogen-activated protein kinases and promotion of cell adhesion and chemotaxis
Glycobiology,
May 1, 2007;
17(5):
492 - 503.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Standal, N. Abildgaard, U.-M. Fagerli, B. Stordal, O. Hjertner, M. Borset, and A. Sundan
HGF inhibits BMP-induced osteoblastogenesis: possible implications for the bone disease of multiple myeloma
Blood,
April 1, 2007;
109(7):
3024 - 3030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Du, Y. Hattori, T. Yamada, K. Matsumoto, T. Nakamura, M. Sagawa, T. Otsuki, T. Niikura, T. Nukiwa, and Y. Ikeda
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor
Blood,
April 1, 2007;
109(7):
3042 - 3049.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Huggins, T. Pellegrin, R. E. Felgar, C. Wei, M. Brown, B. Zheng, E. C. B. Milner, S. H. Bernstein, I. Sanz, and M. S. Zand
CpG DNA activation and plasma-cell differentiation of CD27- naive human B cells
Blood,
February 15, 2007;
109(4):
1611 - 1619.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. D. Theocharis, C. Seidel, M. Borset, K. Dobra, V. Baykov, V. Labropoulou, I. Kanakis, E. Dalas, N. K. Karamanos, A. Sundan, et al.
Serglycin Constitutively Secreted by Myeloma Plasma Cells Is a Potent Inhibitor of Bone Mineralization in Vitro
J. Biol. Chem.,
November 17, 2006;
281(46):
35116 - 35128.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y.-T. Tai, X.-F. Li, I. Breitkreutz, W. Song, P. Neri, L. Catley, K. Podar, T. Hideshima, D. Chauhan, N. Raje, et al.
Role of B-Cell-Activating Factor in Adhesion and Growth of Human Multiple Myeloma Cells in the Bone Marrow Microenvironment.
Cancer Res.,
July 1, 2006;
66(13):
6675 - 6682.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. S. Zand, T. Vo, T. Pellegrin, R. Felgar, J. L. Liesveld, J. J. Ifthikharuddin, C. N. Abboud, I. Sanz, and J. Huggins
Apoptosis and complement-mediated lysis of myeloma cells by polyclonal rabbit antithymocyte globulin
Blood,
April 1, 2006;
107(7):
2895 - 2903.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P. M. Tjin, R. W. J. Groen, I. Vogelzang, P. W. B. Derksen, M. D. Klok, H. P. Meijer, S. van Eeden, S. T. Pals, and M. Spaargaren
Functional analysis of HGF/MET signaling and aberrant HGF-activator expression in diffuse large B-cell lymphoma
Blood,
January 15, 2006;
107(2):
760 - 768.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Dai, Y. Yang, V. MacLeod, X. Yue, A. C. Rapraeger, Z. Shriver, G. Venkataraman, R. Sasisekharan, and R. D. Sanderson
HSulf-1 and HSulf-2 Are Potent Inhibitors of Myeloma Tumor Growth in Vivo
J. Biol. Chem.,
December 2, 2005;
280(48):
40066 - 40073.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P. M. Tjin, R. J. Bende, P. W. B. Derksen, A.-P. van Huijstee, H. Kataoka, M. Spaargaren, and S. T. Pals
Follicular Dendritic Cells Catalyze Hepatocyte Growth Factor (HGF) Activation in the Germinal Center Microenvironment by Secreting the Serine Protease HGF Activator
J. Immunol.,
September 1, 2005;
175(5):
2807 - 2813.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Moreaux, F. W. Cremer, T. Reme, M. Raab, K. Mahtouk, P. Kaukel, V. Pantesco, J. De Vos, E. Jourdan, A. Jauch, et al.
The level of TACI gene expression in myeloma cells is associated with a signature of microenvironment dependence versus a plasmablastic signature
Blood,
August 1, 2005;
106(3):
1021 - 1030.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. A. Mosheimer, N. C. Kaneider, C. Feistritzer, A. M. Djanani, D. H. Sturn, J. R. Patsch, and C. J. Wiedermann
Syndecan-1 Is Involved in Osteoprotegerin-Induced Chemotaxis in Human Peripheral Blood Monocytes
J. Clin. Endocrinol. Metab.,
May 1, 2005;
90(5):
2964 - 2971.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Y. Yang, V. MacLeod, M. Bendre, Y. Huang, A. M. Theus, H.-Q. Miao, P. Kussie, S. Yaccoby, J. Epstein, L. J. Suva, et al.
Heparanase promotes the spontaneous metastasis of myeloma cells to bone
Blood,
February 1, 2005;
105(3):
1303 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
H. Hov, R. U. Holt, T. B. Ro, U.-M. Fagerli, H. Hjorth-Hansen, V. Baykov, J. G. Christensen, A. Waage, A. Sundan, and M. Borset
A Selective c-Met Inhibitor Blocks an Autocrine Hepatocyte Growth Factor Growth Loop in ANBL-6 Cells and Prevents Migration and Adhesion of Myeloma Cells
Clin. Cancer Res.,
October 1, 2004;
10(19):
6686 - 6694.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. P.M. Tjin, P. W.B. Derksen, H. Kataoka, M. Spaargaren, and S. T. Pals
Multiple myeloma cells catalyze hepatocyte growth factor (HGF) activation by secreting the serine protease HGF-activator
Blood,
October 1, 2004;
104(7):
2172 - 2175.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. W. B. Derksen, E. Tjin, H. P. Meijer, M. D. Klok, H. D. Mac Gillavry, M. H. J. van Oers, H. M. Lokhorst, A. C. Bloem, H. Clevers, R. Nusse, et al.
Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
PNAS,
April 20, 2004;
101(16):
6122 - 6127.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. Moreaux, E. Legouffe, E. Jourdan, P. Quittet, T. Reme, C. Lugagne, P. Moine, J.-F. Rossi, B. Klein, and K. Tarte
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
Blood,
April 15, 2004;
103(8):
3148 - 3157.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. Devarajan
Has HGF met other partners? Met-independent epithelial morphogenesis induced by HGF. Focus on "Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity"
Am J Physiol Cell Physiol,
March 1, 2004;
286(3):
C475 - C477.
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. L. Pollack, G. Apodaca, and K. E. Mostov
Hepatocyte growth factor induces MDCK cell morphogenesis without causing loss of tight junction functional integrity
Am J Physiol Cell Physiol,
March 1, 2004;
286(3):
C482 - C494.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
T. Maeda, C. M. Alexander, and A. Friedl
Induction of Syndecan-1 Expression in Stromal Fibroblasts Promotes Proliferation of Human Breast Cancer Cells
Cancer Res.,
January 15, 2004;
64(2):
612 - 621.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Tarte, F. Zhan, J. De Vos, B. Klein, and J. Shaughnessy Jr
Gene expression profiling of plasma cells and plasmablasts: toward a better understanding of the late stages of B-cell differentiation
Blood,
July 15, 2003;
102(2):
592 - 600.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. E. I. Taher, E. P. M. Tjin, E. A. Beuling, J. Borst, M. Spaargaren, and S. T. Pals
c-Cbl Is Involved in Met Signaling in B Cells and Mediates Hepatocyte Growth Factor-Induced Receptor Ubiquitination
J. Immunol.,
October 1, 2002;
169(7):
3793 - 3800.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. A. Stepp, H. E. Gibson, P. H. Gala, D. D. Sta. Iglesia, A. Pajoohesh-Ganji, S. Pal-Ghosh, M. Brown, C. Aquino, A. M. Schwartz, O. Goldberger, et al.
Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse
J. Cell Sci.,
January 12, 2002;
115(23):
4517 - 4531.
[Abstract]
[Full Text]
[PDF]
|
|
|
| |
