SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Martín-Subero, J. I. Articles by Siebert, R. Search for Related Content PubMed PubMed Citation Articles by Martín-Subero, J. I. Articles by Siebert, R. Related Collections Brief Reports Neoplasia Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 February 2002, Vol. 99, No. 4, pp. 1474-1477 BRIEF REPORT Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma José I. Martín-Subero, Stefan Gesk, Lana Harder, Takashi Sonoki, Philip W. Tucker, Brigitte Schlegelberger, Werner Grote, Francisco J. Novo, María J. Calasanz, Martin L. Hansmann, Martin J. S. Dyer, and Reiner Siebert From the Institute of Human Genetics, University Hospital Kiel, Germany; Department of Genetics, University of Navarra, Pamplona, Spain; Internal Medicine II, Kumamoto University School of Medicine, Japan; Institute for Cellular and Molecular Biology, University of Texas at Austin; Department of Pathology, University of Frankfurt, Germany; and Department of Haematology, University of Leicester, United Kingdom. Comparative genomic hybridization studies have shown gains in chromosome region 2p as the most common imbalance in classical Hodgkin lymphoma (cHL). The minimal region of gain contained 2 candidate oncogenes, REL and BCL11A. This study examined the involvement of REL and BCL11A loci in 44 primary cases of cHL by combined immunophenotyping and interphase cytogenetics (FICTION). A median 2p13 copy number above the tetraploid range was detected in 24 (55%) cases. Adjustment for centromere 2 copy number indicated gains of 2p13 in 11 of 31 cHLs (35%) with 8 (26%) high-level amplifications. One cHL displayed selective amplification of the REL locus not affecting BCL11A; another case studied by FICTION and a cHL with cytogenetic 2p change investigated by fluorescence in situ hybridization showed signal patterns suggesting breakpoints in the region spanned by the REL probe. These data indicate that REL rather than BCL11A may be the target of the 2p13 alterations in cHL. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G Kapatai and P Murray Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma J. Clin. Pathol., December 1, 2007; 60(12): 1342 - 1349. [Abstract] [Full Text] [PDF] C. W. Ross, P. D. Ouillette, C. M. Saddler, K. A. Shedden, and S. N. Malek Comprehensive Analysis of Copy Number and Allele Status Identifies Multiple Chromosome Defects Underlying Follicular Lymphoma Pathogenesis Clin. Cancer Res., August 15, 2007; 13(16): 4777 - 4785. [Abstract] [Full Text] [PDF] E Rajcan-Separovic, C Harvard, X Liu, B McGillivray, J G Hall, Y Qiao, J Hurlburt, J Hildebrand, E C R Mickelson, J J A Holden, et al. Clinical and molecular cytogenetic characterisation of a newly recognised microdeletion syndrome involving 2p15-16.1 J. Med. Genet., April 1, 2007; 44(4): 269 - 276. [Abstract] [Full Text] [PDF] P. J. Jost and J. Ruland Aberrant NF-{kappa}B signaling in lymphoma: mechanisms, consequences, and therapeutic implications Blood, April 1, 2007; 109(7): 2700 - 2707. [Abstract] [Full Text] [PDF] J. I. Martin-Subero, W. Klapper, A. Sotnikova, E. Callet-Bauchu, L. Harder, C. Bastard, R. Schmitz, S. Grohmann, J. Hoppner, J. Riemke, et al. Chromosomal Breakpoints Affecting Immunoglobulin Loci Are Recurrent in Hodgkin and Reed-Sternberg Cells of Classical Hodgkin Lymphoma Cancer Res., November 1, 2006; 66(21): 10332 - 10338. [Abstract] [Full Text] [PDF] C. Renne, J. I. Martin-Subero, M. Eickernjager, M.-L. Hansmann, R. Kuppers, R. Siebert, and A. Brauninger Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin's Lymphoma Am. J. Pathol., August 1, 2006; 169(2): 655 - 664. [Abstract] [Full Text] [PDF] D. Re, R. Kuppers, and V. Diehl Molecular Pathogenesis of Hodgkin's Lymphoma J. Clin. Oncol., September 10, 2005; 23(26): 6379 - 6386. [Abstract] [Full Text] [PDF] D. Re, R. K. Thomas, K. Behringer, and V. Diehl From Hodgkin disease to Hodgkin lymphoma: biologic insights and therapeutic potential Blood, June 15, 2005; 105(12): 4553 - 4560. [Abstract] [Full Text] [PDF] C. Renne, K. Willenbrock, R. Kuppers, M.-L. Hansmann, and A. Brauninger Autocrine- and paracrine-activated receptor tyrosine kinases in classic Hodgkin lymphoma Blood, May 15, 2005; 105(10): 4051 - 4059. [Abstract] [Full Text] [PDF] M. A. Shipp, S. L. Aquino, and N. L. Harris Case 12-2005 - A 30-Year-Old Woman with a Mediastinal Mass N. Engl. J. Med., April 21, 2005; 352(16): 1697 - 1704. [Full Text] [PDF] S. Bea, L. Colomo, A. Lopez-Guillermo, I. Salaverria, X. Puig, M. Pinyol, S. Rives, E. Montserrat, and E. Campo Clinicopathologic Significance and Prognostic Value of Chromosomal Imbalances in Diffuse Large B-Cell Lymphomas J. Clin. Oncol., September 1, 2004; 22(17): 3498 - 3506. [Abstract] [Full Text] [PDF] J. Houldsworth, A. B. Olshen, G. Cattoretti, G. B. Donnelly, J. Teruya-Feldstein, J. Qin, N. Palanisamy, Y. Shen, K. Dyomina, M. Petlakh, et al. Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomas Blood, March 1, 2004; 103(5): 1862 - 1868. [Abstract] [Full Text] [PDF] K. J. Savage, S. Monti, J. L. Kutok, G. Cattoretti, D. Neuberg, L. de Leval, P. Kurtin, P. D. Cin, C. Ladd, F. Feuerhake, et al. The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma Blood, December 1, 2003; 102(12): 3871 - 3879. [Abstract] [Full Text] [PDF] D. Re, P. Starostik, N. Massoudi, A. Staratschek-Jox, V. Dries, R. K. Thomas, V. Diehl, and J. Wolf Allelic Losses on Chromosome 6q25 in Hodgkin and Reed Sternberg Cells Cancer Res., May 15, 2003; 63(10): 2606 - 2609. [Abstract] [Full Text] [PDF] T. F. E. Barth, J. I. Martin-Subero, S. Joos, C. K. Menz, C. Hasel, G. Mechtersheimer, R. M. Parwaresch, P. Lichter, R. Siebert, and P. Moller Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphoma Blood, May 1, 2003; 101(9): 3681 - 3686. [Abstract] [Full Text] [PDF] J. A. Martinez-Climent, A. A. Alizadeh, R. Segraves, D. Blesa, F. Rubio-Moscardo, D. G. Albertson, J. Garcia-Conde, M. J. S. Dyer, R. Levy, D. Pinkel, et al. Transformation of follicular lymphoma to diffuse large cell lymphoma is associated with a heterogeneous set of DNA copy number and gene expression alterations Blood, April 15, 2003; 101(8): 3109 - 3117. [Abstract] [Full Text] [PDF] M. Sanchez-Beato, A. Sanchez-Aguilera, and M. A. Piris Cell cycle deregulation in B-cell lymphomas Blood, February 15, 2003; 101(4): 1220 - 1235. [Abstract] [Full Text] [PDF] I. Wlodarska, P. Nooyen, B. Maes, J. I. Martin-Subero, R. Siebert, P. Pauwels, C. De Wolf-Peeters, and A. Hagemeijer Frequent occurrence of BCL6 rearrangements in nodular lymphocyte predominance Hodgkin lymphoma but not in classical Hodgkin lymphoma Blood, January 15, 2003; 101(2): 706 - 710. [Abstract] [Full Text] [PDF] S. Joos, C. K. Menz, G. Wrobel, R. Siebert, S. Gesk, S. Ohl, G. Mechtersheimer, L. Trumper, P. Moller, P. Lichter, et al. Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2 Blood, February 15, 2002; 99(4): 1381 - 1387. [Abstract] [Full Text] [PDF]

	Blood Online is supported in part by Genentech BioOncology and Biogen Idec
	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020