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This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Mast, A. E. Articles by Dietzen, D. J. Search for Related Content PubMed PubMed Citation Articles by Mast, A. E. Articles by Dietzen, D. J. Related Collections Red Cells Brief Reports Related Letter in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 15 February 2002, Vol. 99, No. 4, pp. 1489-1491 BRIEF REPORT Clinical utility of the reticulocyte hemoglobin content in the diagnosis of iron deficiency Alan E. Mast, Morey A. Blinder, Qing Lu, Sherri Flax, and Dennis J. Dietzen From the Research and Pathology Services, Department of Veterans Affairs, Memphis, TN; the Department of Pathology, University of Tennessee, Memphis; and the Department of Pathology and Immunology, Washington University, St Louis, MO. Determination of the reticulocyte hemoglobin content (CHr) provides an early measure of functional iron deficiency because reticulocytes are the earliest erythrocytes released into blood and circulate for only 1 to 2 days. The CHr in 78 patients undergoing bone marrow examination was measured to assess its clinical utility for the diagnosis of iron deficiency. Twenty-eight patients were iron deficient, based on the lack of stainable iron in the aspirate. The diagnostic power of CHr is limited in patients with high mean cellular volume (MCV) or red cell disorders such as thalassemia. However, when patients with MCV more than 100 fL are excluded, receiver operator curve analysis of CHr, ferritin, transferrin saturation, and MCV demonstrates that CHr has the highest overall sensitivity and specificity of these peripheral blood tests for predicting the absence of bone marrow iron stores. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Letter in Blood Online: Iron status indicators: hello new, goodbye old? Ivor A. Cavill Blood 2003 101: 372. [Full Text] [PDF] This article has been cited by other articles: C. Ullrich, A. Wu, C. Armsby, S. Rieber, S. Wingerter, C. Brugnara, D. Shapiro, and H. Bernstein Screening Healthy Infants for Iron Deficiency Using Reticulocyte Hemoglobin Content JAMA, August 24, 2005; 294(8): 924 - 930. [Abstract] [Full Text] [PDF] K. C. White Anemia Is a Poor Predictor of Iron Deficiency Among Toddlers in the United States: For Heme the Bell Tolls Pediatrics, February 1, 2005; 115(2): 315 - 320. [Abstract] [Full Text] [PDF] E. Beutler, A. V. Hoffbrand, and J. D. Cook Iron Deficiency and Overload Hematology, January 1, 2003; 2003(1): 40 - 61. [Abstract] [Full Text] [PDF] I. A. Cavill Iron status indicators: hello new, goodbye old? Blood, January 1, 2003; 101(1): 372 - 372. [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020