|
|
 Previous Article | Table of Contents | Next Article 
Blood, 1 March 2002, Vol. 99, No. 5, pp. 1853-1856
BRIEF REPORT
Immunophenotypic evaluation of the plasma cell compartment in
multiple myeloma: a tool for comparing the efficacy of different
treatment strategies and predicting outcome
Jesús F. San Miguel,
Julia Almeida,
Gema Mateo,
Joan Bladé,
Consuelo López-Berges,
Dolores Caballero,
José Hernández,
María Jesús Moro,
Javier Fernández-Calvo,
Joaquín Díaz-Mediavilla,
Luis Palomera, and
Alberto Orfao
From Servicio de Hematología, Hospital
Clínico Universitario, Salamanca; Centro de Investigación
del Cáncer, Salamanca; Servicio de Citometría,
Universidad de Salamanca; Hospital Clinic i Provincial, Barcelona;
Hospital General, Segovia; Hospital Virgen Blanca, León; Hospital
Clínico Universitario, Valladolid; Hospital Clínico,
Madrid; and Hospital Clínico, Zaragoza, Spain.
Multiparametric immunophenotyping can be a sensitive method
for analyzing the plasma cell (PC) compartment in patients with multiple myeloma because it discriminates between myelomatous and
normal PCs. Using this approach, we compared the efficacy of high-dose
chemotherapy followed by autologous stem cell transplantation (ASCT)
with that of conventional chemotherapy. We found that ASCT provided a
significantly greater reduction in the level of residual tumor PCs and
with better recovery of normal PCs. This profile of coexistence of
normal PCs and myelomatous PCs resembled that observed in monoclonal
gammopathy of undetermined significance. We also found that
treatment-induced changes in the PC compartment correlated with disease
outcome. Thus, patients in whom at least 30% of gated PCs had a normal
phenotype after treatment had a significantly longer progression-free
survival (60 ± 6 months versus 34 ± 12 months;
P = .02).
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
J. J. Lahuerta, M. V. Mateos, J. Martinez-Lopez, L. Rosinol, A. Sureda, J. de la Rubia, J. Garcia-Larana, R. Martinez-Martinez, M. T. Hernandez-Garcia, D. Carrera, et al.
Influence of Pre- and Post-Transplantation Responses on Outcome of Patients With Multiple Myeloma: Sequential Improvement of Response and Achievement of Complete Response Are Associated With Longer Survival
J. Clin. Oncol.,
December 10, 2008;
26(35):
5775 - 5782.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
B. Paiva, M.-B. Vidriales, J. Cervero, G. Mateo, J. J. Perez, M. A. Montalban, A. Sureda, L. Montejano, N. C. Gutierrez, A. G. de Coca, et al.
Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation
Blood,
November 15, 2008;
112(10):
4017 - 4023.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Tabera, J. A. Perez-Simon, M. Diez-Campelo, L. I. Sanchez-Abarca, B. Blanco, A. Lopez, A. Benito, E. Ocio, F. M. Sanchez-Guijo, C. Canizo, et al.
The effect of mesenchymal stem cells on the viability, proliferation and differentiation of B-lymphocytes
Haematologica,
September 1, 2008;
93(9):
1301 - 1309.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. C. Rawstron, A. Orfao, M. Beksac, L. Bezdickova, R. A. Brooimans, H. Bumbea, K. Dalva, G. Fuhler, J. Gratama, D. Hose, et al.
Report of the European Myeloma Network on multiparametric flow cytometry in multiple myeloma and related disorders
Haematologica,
March 1, 2008;
93(3):
431 - 438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. C. Munshi
Investigative Tools for Diagnosis and Management
Hematology,
January 1, 2008;
2008(1):
298 - 305.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. Perez-Persona, M.-B. Vidriales, G. Mateo, R. Garcia-Sanz, M.-V. Mateos, A. G. de Coca, J. Galende, G. Martin-Nunez, J. M. Alonso, N. de las Heras, et al.
New criteria to identify risk of progression in monoclonal gammopathy of uncertain significance and smoldering multiple myeloma based on multiparameter flow cytometry analysis of bone marrow plasma cells
Blood,
October 1, 2007;
110(7):
2586 - 2592.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M.-V. Mateos, J.-M. Hernandez, M.-T. Hernandez, N.-C. Gutierrez, L. Palomera, M. Fuertes, J. Diaz-Mediavilla, J.-J. Lahuerta, J. de la Rubia, M.-J. Terol, et al.
Bortezomib plus melphalan and prednisone in elderly untreated patients with multiple myeloma: results of a multicenter phase 1/2 study
Blood,
October 1, 2006;
108(7):
2165 - 2172.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
