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Blood, 1 March 2002, Vol. 99, No. 5, pp. 1863-1865
BRIEF REPORT
Autocrine production of epithelial cell-derived neutrophil
attractant-78 induced by granulocyte colony-stimulating factor in
neutrophils
Sachiko Suzuki,
Masanobu Kobayashi,
Kouji Chiba,
Iori Horiuchi,
Jingxin Wang,
Takeshi Kondoh,
Satoshi Hashino,
Junji Tanaka,
Masuo Hosokawa, and
Masahiro Asaka
From the Division of Cancer Pathobiology, Institute for
Genetic Medicine, Hokkaido University, the Department of
Gastroenterology and Hematology, Department of Hematology and Oncology,
Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Whereas mobilization to inflammatory sites is an important function
of neutrophils, it remains to be determined whether granulocyte colony-stimulating factor (G-CSF) stimulates the mobilization of
neutrophils to the inflammatory sites. This study compared the
expression of more than 9000 genes in neutrophils treated with and
without G-CSF with the use of a DNA microarray system to determine the
effects of G-CSF on the function of neutrophils. It was found that
messenger RNA expression of epithelial cell-derived neutrophil
attractant-78 (ENA-78), which has been reported to be a chemotactic
factor for neutrophils, was induced by G-CSF in neutrophils. The study
demonstrated that the supernatant of G-CSF-treated neutrophils induced
the chemotaxis of neutrophils and that anti-ENA-78 antibody and
anti-CXCR-2 antibody inhibited the chemotaxis. These data suggest that
G-CSF may enhance the mobilization of neutrophils and consequently
augment the accumulation of neutrophils in the inflammatory sites
through the secretion of ENA-78.
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