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Blood, 15 March 2002, Vol. 99, No. 6, pp. 1913-1921
CHEMOKINES
BCR ligation reprograms B cells for migration to the T zone
and B-cell follicle sequentially
Montserrat Casamayor-Pallejà,
Paul Mondière,
Claire Verschelde,
Chantal Bella, and
Thierry Defrance
From INSERM U404, Immunité et Vaccination, and
INSERM U503 (C.V.), Lyon, France.
We have studied the impact of B-cell receptor (BCR) or CD40
ligation on the in vitro chemotactic response of tonsillar B cells to 4 chemokines: stromal cell-derived factor (SDF)-1 , macrophage inflammatory protein (MIP)-3, MIP-3 , and B-cell-attracting
chemokine (BCA)-1. In the tonsil, SDF-1 and MIP-3 are both
expressed in the crypt epithelium, while MIP-3 is found in the T
zone and BCA-1 in the follicles. Resting virgin and memory B cells
display a similar chemotaxis pattern, and they both have the potential to migrate in vitro to all 4 chemokines studied. This pattern of
responsiveness is strongly modified by a surrogate antigen (Ag) but is
not altered by CD40 ligand. We report here that surrogate Ag induces a
profound and sustained suppression of the response to the crypt
chemokines SDF-1 and MIP-3, while it exacerbates the migratory
response to MIP-3. The effect of surrogate Ag on the response to
BCA-1 is biphasic: After an initial phase of suppression, chemotaxis
toward BCA-1 is strongly up-regulated. Our results suggest that Ag is
primarily responsible for reprogramming the B-cell chemotaxis
responsiveness during the humoral response. We propose that it
initiates an ordered change of the chemotaxis machinery allowing
Ag-activated B cells to relocate in the T zone and B-cell follicles sequentially.
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