|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 March 2002, Vol. 99, No. 6, pp. 2172-2178
NEOPLASIA
Requirements of src family kinase activity associated with
CD45 for myeloma cell proliferation by interleukin-6
Hideaki Ishikawa,
Naohiro Tsuyama,
Saeid Abroun,
Shangqin Liu,
Fu-Jun Li,
Osamu Taniguchi, and
Michio M. Kawano
From the Department of Bio-Signal Analysis, Applied
Medical Engineering Science, Graduate School of Medicine, Yamaguchi
University, Ube, Japan; and Otsuka Tokyo Assay Laboratories, Tokyo,
Japan.
Specific intracellular signals mediated by interleukin-6 (IL-6)
receptor complexes, such as signal transducer and activator of
transcription 3 (STAT 3) and extracellular signal-regulated kinase
(ERK) 1/2, are considered to be responsible for inducing a variety of
cellular responses. In multiple myeloma, IL-6 only enhanced the
proliferation of CD45+ tumor cells that harbored the
IL-6-independent activation of src family kinases even though STAT3
and ERK1/2 could be activated in response to IL-6 in both
CD45+ and CD45 cells. Furthermore, the
IL-6-induced proliferation of CD45+ U266 myeloma cells was
significantly suppressed by Lyn-specific antisense
oligodeoxynucleotides or a selective src kinase inhibitor. These
results indicate that the activation of both STAT3 and ERK1/2 is not
enough for IL-6-induced proliferation of myeloma cell lines that
require src family kinase activation independent of IL-6 stimulation. Thus, the activation of the src family kinases associated with CD45 expression is a prerequisite for the proliferation of myeloma
cell lines by IL-6. We propose a mechanism for IL-6-induced cell
proliferation that is strictly dependent upon the cellular context in myelomas.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
E. Menoret, S. Maiga, G. Descamps, C. Pellat-Deceunynck, C. Fraslon, M. Cappellano, P. Moreau, R. Bataille, and M. Amiot
IL-21 Stimulates Human Myeloma Cell Growth through an Autocrine IGF-1 Loop
J. Immunol.,
November 15, 2008;
181(10):
6837 - 6842.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
L. Pedranzini, T. Dechow, M. Berishaj, R. Comenzo, P. Zhou, J. Azare, W. Bornmann, and J. Bromberg
Pyridone 6, A Pan-Janus-Activated Kinase Inhibitor, Induces Growth Inhibition of Multiple Myeloma Cells
Cancer Res.,
October 1, 2006;
66(19):
9714 - 9721.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Descamps, S. Wuilleme-Toumi, V. Trichet, C. Venot, L. Debussche, T. Hercend, M. Collette, N. Robillard, R. Bataille, and M. Amiot
CD45neg but Not CD45pos Human Myeloma Cells Are Sensitive to the Inhibition of IGF-1 Signaling by a Murine Anti-IGF-1R Monoclonal Antibody, mAVE1642
J. Immunol.,
September 15, 2006;
177(6):
4218 - 4223.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. Robillard, C. Pellat-Deceunynck, and R. Bataille
Phenotypic characterization of the human myeloma cell growth fraction
Blood,
June 15, 2005;
105(12):
4845 - 4848.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
O. Prakash, O. R. Swamy, X. Peng, Z.-Y. Tang, L. Li, J. E. Larson, J. C. Cohen, J. Gill, G. Farr, S. Wang, et al.
Activation of Src kinase Lyn by the Kaposi sarcoma-associated herpesvirus K1 protein: implications for lymphomagenesis
Blood,
May 15, 2005;
105(10):
3987 - 3994.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F.-J. Li, N. Tsuyama, H. Ishikawa, M. Obata, S. Abroun, S. Liu, K.-i. Otsuyama, X. Zheng, Z. Ma, Y. Maki, et al.
A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma
Blood,
April 15, 2005;
105(8):
3295 - 3302.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Liu, H. Ishikawa, F.-J. Li, Z. Ma, K.-i. Otsuyama, H. Asaoku, S. Abroun, X. Zheng, N. Tsuyama, M. Obata, et al.
Dehydroepiandrosterone Can Inhibit the Proliferation of Myeloma Cells and the Interleukin-6 Production of Bone Marrow Mononuclear Cells from Patients with Myeloma
Cancer Res.,
March 15, 2005;
65(6):
2269 - 2276.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F.-J. Li, N. Tsuyama, H. Ishikawa, M. Obata, S. Abroun, S. Liu, K. Otsuyama, X. Zheng, Z. Ma, Y. Maki, et al.
IL-6 Induced CD45RO, RB Translocation to Lipid Rafts in Myeloma Cells.
Blood (ASH Annual Meeting Abstracts),
November 16, 2004;
104(11):
3344 - 3344.
[Abstract]
|
|
|
|
|
|
|
G. Descamps, C. Pellat-Deceunynck, Y. Szpak, R. Bataille, N. Robillard, and M. Amiot
The Magnitude of Akt/Phosphatidylinositol 3'-Kinase Proliferating Signaling Is Related to CD45 Expression in Human Myeloma Cells
J. Immunol.,
October 15, 2004;
173(8):
4953 - 4959.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Abroun, H. Ishikawa, N. Tsuyama, S. Liu, F.-J. Li, K.-i. Otsuyama, X. Zheng, M. Obata, and M. M. Kawano
Receptor synergy of interleukin-6 (IL-6) and insulin-like growth factor-I in myeloma cells that highly express IL-6 receptor {alpha}
Blood,
March 15, 2004;
103(6):
2291 - 2298.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
W. Chien, N. Tidow, E. A. Williamson, L.-Y. Shih, U. Krug, A. Kettenbach, A. C. Fermin, C. M. Roifman, and H. P. Koeffler
Characterization of a Myeloid Tyrosine Phosphatase, Lyp, and Its Role in the Bcr-Abl Signal Transduction Pathway
J. Biol. Chem.,
July 18, 2003;
278(30):
27413 - 27420.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asosingh, A. Willems, I. Van Riet, B. Van Camp, and K. Vanderkerken
Delayed in Vivo Disease Progression Is Associated with High Proportions of CD45+ Myeloma Cells in the 5T2MM Murine Model
Cancer Res.,
June 15, 2003;
63(12):
3019 - 3020.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. Asosingh, H. De Raeve, I. Van Riet, B. Van Camp, and K. Vanderkerken
Multiple myeloma tumor progression in the 5T2MM murine model is a multistage and dynamic process of differentiation, proliferation, invasion, and apoptosis
Blood,
April 15, 2003;
101(8):
3136 - 3141.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
N. J. Donato, J. Y. Wu, J. Stapley, G. Gallick, H. Lin, R. Arlinghaus, and M. Talpaz
BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571
Blood,
January 15, 2003;
101(2):
690 - 698.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
