|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 March 2002, Vol. 99, No. 6, pp. 2259-2261
BRIEF REPORT
Regression of lymphoproliferative disorder after treatment for
hepatitis C virus infection in a patient with partial trisomy 3, Bcl-2
overexpression, and type II cryoglobulinemia
Milvia Casato,
Cristina Mecucci,
Vincent Agnello,
Massimo Fiorilli,
Glenn B. Knight,
Caterina Matteucci,
Lei Gao, and
Jonathan Kay
From the Department of Clinical Medicine, University of Rome La
Sapienza, Rome, Italy; Hematology, University of Perugia, Italy; Lahey
Clinic, Burlington, MA; Veterans Affairs Medical Center, Bedford, MA.
A patient with type II cryoglobulinemic vasculitis and
hepatitis C virus (HCV) infection presented with a leukemiclike
proliferation of B cells bearing marginal zone B-cell phenotypic
markers. A partial trisomy 3 (bands 3q11-29) and overexpression of
Bcl-2 without t(14;18) translocation was detected in the monoclonal B
cells that were classic rheumatoid factor-producing B cells bearing
the WA cross-idiotype. Treatment with interferon- produced a
complete clinical remission and synchronous marked decreases in viremia
and monoclonal B-cell prevalence. This is the first report of partial
trisomy 3 and Bcl-2 overexpression in type II cryoglobulinemic
vasculitis associated with HCV infection. Further studies of
HCV-infected patients with and without type II cryoglobulinemia are
required to determine the prevalence and possible physiologic and/or
pathophysiologic significance of these findings.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
R. J. Bende, F. van Maldegem, and C. J.M. van Noesel
Chronic inflammatory disease, lymphoid tissue neogenesis and extranodal marginal zone B-cell lymphomas
Haematologica,
August 1, 2009;
94(8):
1109 - 1123.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Z. Stamataki, C. Shannon-Lowe, J. Shaw, D. Mutimer, A. B. Rickinson, J. Gordon, D. H. Adams, P. Balfe, and J. A. McKeating
Hepatitis C virus association with peripheral blood B lymphocytes potentiates viral infection of liver-derived hepatoma cells
Blood,
January 15, 2009;
113(3):
585 - 593.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E. D. Charles, R. M. Green, S. Marukian, A. H. Talal, G. V. Lake-Bakaar, I. M. Jacobson, C. M. Rice, and L. B. Dustin
Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia
Blood,
February 1, 2008;
111(3):
1344 - 1356.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D S Viswanatha and A Dogan
Hepatitis C virus and lymphoma
J. Clin. Pathol.,
December 1, 2007;
60(12):
1378 - 1383.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Bianchettin, C. Bonaccini, R. Oliva, A. Tramontano, A. Cividini, M. Casato, G. Merlini, E. Silini, and M. U. Mondelli
Analysis of Hepatitis C Virus Hypervariable Region 1 Sequence from Cryoglobulinemic Patients and Associated Controls
J. Virol.,
May 1, 2007;
81(9):
4564 - 4571.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C Visco, L Arcaini, E Brusamolino, S Burcheri, A Ambrosetti, M Merli, E Bonoldi, M Chilosi, A Viglio, M Lazzarino, et al.
Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy
Ann. Onc.,
September 1, 2006;
17(9):
1434 - 1440.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Carbonari, E. Caprini, T. Tedesco, F. Mazzetta, V. Tocco, M. Casato, G. Russo, and M. Fiorilli
Hepatitis C Virus Drives the Unconstrained Monoclonal Expansion of VH1-69-Expressing Memory B Cells in Type II Cryoglobulinemia: A Model of Infection-Driven Lymphomagenesis
J. Immunol.,
May 15, 2005;
174(10):
6532 - 6539.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
R. J. Bende, W. M. Aarts, R. G. Riedl, D. de Jong, S. T. Pals, and C. J.M. van Noesel
Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity
J. Exp. Med.,
April 18, 2005;
201(8):
1229 - 1241.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
D. Saadoun, F. Suarez, F. Lefrere, F. Valensi, X. Mariette, A. Aouba, C. Besson, B. Varet, X. Troussard, P. Cacoub, et al.
Splenic lymphoma with villous lymphocytes, associated with type II cryoglobulinemia and HCV infection: a new entity?
Blood,
January 1, 2005;
105(1):
74 - 76.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
F. Giannelli, S. Moscarella, C. Giannini, P. Caini, M. Monti, L. Gragnani, R. G. Romanelli, V. Solazzo, G. Laffi, G. La Villa, et al.
Effect of antiviral treatment in patients with chronic HCV infection and t(14;18) translocation
Blood,
August 15, 2003;
102(4):
1196 - 1201.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
C. Mazzaro, D'A. Little, G. Pozzato, L. A. Emens, M. S. Sulkowski, V. Agnello, C. Mecucci, M. Casato, F. Lefrere, X. Troussard, et al.
Regression of Splenic Lymphoma after Treatment of Hepatitis C Virus Infection
N. Engl. J. Med.,
December 26, 2002;
347(26):
2168 - 2170.
[Full Text]
[PDF]
|
|
|
|
|
