Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tobin, G.
Right arrow Articles by Rosenquist, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tobin, G.
Right arrow Articles by Rosenquist, R.
Related Collections
Right arrow Brief Reports
Right arrow Clinical Trials and Observations
Right arrow Neoplasia
Right arrowRelated Letters in Blood Online
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Table of Contents  |  Next Article next article arrow

Blood, 15 March 2002, Vol. 99, No. 6, pp. 2262-2264

BRIEF REPORT

Somatically mutated Ig VH3-21 genes characterize a new subset of chronic lymphocytic leukemia

Gerard Tobin, Ulf Thunberg, Anna Johnson, Ingrid Thörn, Ola Söderberg, Magnus Hultdin, Johan Botling, Gunilla Enblad, Jan Sällström, Christer Sundström, Göran Roos, and Richard Rosenquist

From the Departments of Genetics and Pathology and Oncology, Radiology and Clinical Immunology, Uppsala University, Uppsala, Sweden, and the Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

Recent studies on the immunoglobulin variable heavy chain (IgVH) genes have revealed that B-cell chronic lymphocytic leukemia (B-CLL) consists of at least 2 clinical entities with either somatically mutated or unmutated VH genes. We have analyzed the VH gene mutation status and VH gene usage in 119 B-CLL cases and correlated them to overall survival. A novel finding was the preferential use of the VH3-21 gene in mutated cases, whereas biased VH1-69 gene usage was found in unmutated cases as previously reported. Interestingly, the subset of mutated cases using the VH3-21 gene displayed distinctive genotypic/phenotypic characteristics with shorter average length of the complementarity determining region 3 and clonal expression of lambda  light chains. In addition, this mutated subset showed significantly shorter survival than other mutated cases and a similar clinical course to unmutated cases. We therefore suggest that B-CLL cases with mutated VH3-21 genes may constitute an additional entity of B-CLL.

© 2002 by The American Society of Hematology.
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?

Related Letters in Blood Online:

Do B-cell chronic lymphocytic leukemia patients with Ig VH3-21 genes constitute a new subset of chronic lymphocytic leukemia?
Friedel Nollet, Barbara Cauwelier, Johan Billiet, Dominik Selleslag, Achiel Van Hoof, Andries Louwagie, Arnold Criel, Gerard Tobin, Ulf Thunberg, Anna Johnson, Ola Söderberg, Johan Botling, Gunilla Enblad, Jan Sällström, Christer Sundström, Göran Roos, and Richard Rosenquist
Blood 2002 100: 1097-1099. [Full Text] [PDF]

High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment
Ke Lin, Sameer Manocha, Robert J. Harris, Zoltan Matrai, Paul D. Sherrington, and Andrew R. Pettitt
Blood 2003 102: 1145-1146. [Full Text] [PDF]



This article has been cited by other articles:


Home page
 BloodHome page
M. Muzio, B. Apollonio, C. Scielzo, M. Frenquelli, I. Vandoni, V. Boussiotis, F. Caligaris-Cappio, and P. Ghia
Constitutive activation of distinct BCR-signaling pathways in a subset of CLL patients: a molecular signature of anergy
Blood, July 1, 2008; 112(1): 188 - 195.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. M. Ghia, S. Jain, G. F. Widhopf II, L. Z. Rassenti, M. J. Keating, W. G. Wierda, J. G. Gribben, J. R. Brown, K. R. Rai, J. C. Byrd, et al.
Use of IGHV3-21 in chronic lymphocytic leukemia is associated with high-risk disease and reflects antigen-driven, post-germinal center leukemogenic selection
Blood, May 15, 2008; 111(10): 5101 - 5108.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. F. Widhopf II, C. J. Goldberg, T. L. Toy, L. Z. Rassenti, W. G. Wierda, J. C. Byrd, M. J. Keating, J. G. Gribben, K. R. Rai, and T. J. Kipps
Nonstochastic pairing of immunoglobulin heavy and light chains expressed by chronic lymphocytic leukemia B cells is predicated on the heavy chain CDR3
Blood, March 15, 2008; 111(6): 3137 - 3144.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. Murray, N. Darzentas, A. Hadzidimitriou, G. Tobin, M. Boudjogra, C. Scielzo, N. Laoutaris, K. Karlsson, F. Baran-Marzsak, A. Tsaftaris, et al.
Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis
Blood, February 1, 2008; 111(3): 1524 - 1533.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Gattei, P. Bulian, M. I. Del Principe, A. Zucchetto, L. Maurillo, F. Buccisano, R. Bomben, M. Dal-Bo, F. Luciano, F. M. Rossi, et al.
Relevance of CD49d protein expression as overall survival and progressive disease prognosticator in chronic lymphocytic leukemia
Blood, January 15, 2008; 111(2): 865 - 873.
[Abstract] [Full Text] [PDF]

Home page
 BioinformaticsHome page
B. A. Gaeta, H. R. Malming, K. J.L. Jackson, M. E. Bain, P. Wilson, and A. M. Collins
iHMMune-align: hidden Markov model-based alignment and identification of germline genes in rearranged immunoglobulin gene sequences
Bioinformatics, July 1, 2007; 23(13): 1580 - 1587.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Pathol.Home page
E. Sabattini, R. Orduz, C. Campidelli, P. L. Zinzani, V. Callea, S. Zupo, G. Cutrona, F. Morabito, M. Ferrarini, and S. Pileri
B cell chronic lymphocytic leukaemia/small lymphocytic lymphoma: role of ZAP70 determination on bone marrow biopsy specimens
J. Clin. Pathol., June 1, 2007; 60(6): 627 - 632.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
R. Bomben, M. Dal Bo, D. Capello, D. Benedetti, D. Marconi, A. Zucchetto, F. Forconi, R. Maffei, E. M. Ghia, L. Laurenti, et al.
Comprehensive characterization of IGHV3-21-expressing B-cell chronic lymphocytic leukemia: an Italian multicenter study
Blood, April 1, 2007; 109(7): 2989 - 2998.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. D. Volkheimer, J. B. Weinberg, B. E. Beasley, J. F. Whitesides, J. P. Gockerman, J. O. Moore, G. Kelsoe, B. K. Goodman, and M. C. Levesque
Progressive immunoglobulin gene mutations in chronic lymphocytic leukemia: evidence for antigen-driven intraclonal diversification
Blood, February 15, 2007; 109(4): 1559 - 1567.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Stamatopoulos, C. Belessi, C. Moreno, M. Boudjograh, G. Guida, T. Smilevska, L. Belhoul, S. Stella, N. Stavroyianni, M. Crespo, et al.
Over 20% of patients with chronic lymphocytic leukemia carry stereotyped receptors: pathogenetic implications and clinical correlations
Blood, January 1, 2007; 109(1): 259 - 270.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
X.-j. Yan, E. Albesiano, N. Zanesi, S. Yancopoulos, A. Sawyer, E. Romano, A. Petlickovski, D. G. Efremov, C. M. Croce, and N. Chiorazzi
B cell receptors in TCL1 transgenic mice resemble those of aggressive, treatment-resistant human chronic lymphocytic leukemia
PNAS, August 1, 2006; 103(31): 11713 - 11718.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
M. Thorselius, A. Krober, F. Murray, U. Thunberg, G. Tobin, A. Buhler, D. Kienle, E. Albesiano, R. Maffei, L.-P. Dao-Ung, et al.
Strikingly homologous immunoglobulin gene rearrangements and poor outcome in VH3-21-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status
Blood, April 1, 2006; 107(7): 2889 - 2894.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
D. Kienle, A. Benner, A. Krober, D. Winkler, D. Mertens, A. Buhler, T. Seiler, U. Jager, P. Lichter, H. Dohner, et al.
Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes
Blood, March 1, 2006; 107(5): 2090 - 2093.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
A. Krober, J. Bloehdorn, S. Hafner, A. Buhler, T. Seiler, D. Kienle, D. Winkler, M. Bangerter, R. F. Schlenk, A. Benner, et al.
Additional Genetic High-Risk Features Such As 11q Deletion, 17p Deletion, and V3-21 Usage Characterize Discordance of ZAP-70 and VH Mutation Status in Chronic Lymphocytic Leukemia
J. Clin. Oncol., February 20, 2006; 24(6): 969 - 975.
[Abstract] [Full Text] [PDF]

Home page
 Ann. N. Y. Acad. Sci.Home page
N. CHIORAZZI, K. HATZI, and E. ALBESIANO
B-Cell Chronic Lymphocytic Leukemia, a Clonal Disease of B Lymphocytes with Receptors that Vary in Specificity for (Auto)antigens
Ann. N.Y. Acad. Sci., December 1, 2005; 1062(1): 1 - 12.
[Abstract] [Full Text] [PDF]

Home page
 ASH ANNUAL MEETING ABSTRACTSHome page
M. Trbusek, V. Kuhrova, J. Malcikova, J. Smardova, H. Francova, D. Mentzlova, S. Bukovska, M. Svitakova, P. Kuglik, V. Linkova, et al.
Characterization of p53 Abnormalities in CLL Patients in Relation to IGVH Mutation Status and Previous Treatment.
Blood (ASH Annual Meeting Abstracts), November 16, 2005; 106(11): 2947 - 2947.
[Abstract]

Home page
 BloodHome page
K. Stamatopoulos, C. Belessi, A. Hadzidimitriou, T. Smilevska, E. Kalagiakou, K. Hatzi, N. Stavroyianni, A. Athanasiadou, A. Tsompanakou, T. Papadaki, et al.
Immunoglobulin light chain repertoire in chronic lymphocytic leukemia
Blood, November 15, 2005; 106(10): 3575 - 3583.
[Abstract] [Full Text] [PDF]

Home page
 J. Mol. Diagn.Home page
R. Marasca, R. Maffei, M. Morselli, P. Zucchini, I. Castelli, S. Martinelli, M. Fontana, S. Ravanetti, M. Curotti, G. Leonardi, et al.
Immunoglobulin Mutational Status Detected through Single-Round Amplification of Partial VH Region Represents a Good Prognostic Marker for Clinical Outcome in Chronic Lymphocytic Leukemia
J. Mol. Diagn., November 1, 2005; 7(5): 566 - 574.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. Falt, M. Merup, G. Tobin, U. Thunberg, G. Gahrton, R. Rosenquist, and A. Wennborg
Distinctive gene expression pattern in VH3-21 utilizing B-cell chronic lymphocytic leukemia
Blood, July 15, 2005; 106(2): 681 - 689.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Grabowski, M. Hultdin, K. Karlsson, G. Tobin, A. Aleskog, U. Thunberg, A. Laurell, C. Sundstrom, R. Rosenquist, and G. Roos
Telomere length as a prognostic parameter in chronic lymphocytic leukemia with special reference to VH gene mutation status
Blood, June 15, 2005; 105(12): 4807 - 4812.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
N. Chiorazzi, K. R. Rai, and M. Ferrarini
Chronic Lymphocytic Leukemia
N. Engl. J. Med., February 24, 2005; 352(8): 804 - 815.
[Full Text] [PDF]

Home page
 BloodHome page
P. Ghia, K. Stamatopoulos, C. Belessi, C. Moreno, S. Stella, G. Guida, A. Michel, M. Crespo, N. Laoutaris, E. Montserrat, et al.
Geographic patterns and pathogenetic implications of IGHV gene usage in chronic lymphocytic leukemia: the lesson of the IGHV3-21 gene
Blood, February 15, 2005; 105(4): 1678 - 1685.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Tobin, U. Thunberg, K. Karlsson, F. Murray, A. Laurell, K. Willander, G. Enblad, M. Merup, J. Vilpo, G. Juliusson, et al.
Subsets with restricted immunoglobulin gene rearrangement features indicate a role for antigen selection in the development of chronic lymphocytic leukemia
Blood, November 1, 2004; 104(9): 2879 - 2885.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. F. Widhopf II, L. Z. Rassenti, T. L. Toy, J. G. Gribben, W. G. Wierda, and T. J. Kipps
Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins
Blood, October 15, 2004; 104(8): 2499 - 2504.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
C. Haslinger, N. Schweifer, S. Stilgenbauer, H. Dohner, P. Lichter, N. Kraut, C. Stratowa, and R. Abseher
Microarray Gene Expression Profiling of B-Cell Chronic Lymphocytic Leukemia Subgroups Defined by Genomic Aberrations and VH Mutation Status
J. Clin. Oncol., October 1, 2004; 22(19): 3937 - 3949.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
L. Z. Rassenti, L. Huynh, T. L. Toy, L. Chen, M. J. Keating, J. G. Gribben, D. S. Neuberg, I. W. Flinn, K. R. Rai, J. C. Byrd, et al.
ZAP-70 Compared with Immunoglobulin Heavy-Chain Gene Mutation Status as a Predictor of Disease Progression in Chronic Lymphocytic Leukemia
N. Engl. J. Med., August 26, 2004; 351(9): 893 - 901.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
B. T. Messmer, E. Albesiano, D. G. Efremov, F. Ghiotto, S. L. Allen, J. Kolitz, R. Foa, R. N. Damle, F. Fais, D. Messmer, et al.
Multiple Distinct Sets of Stereotyped Antigen Receptors Indicate a Role for Antigen in Promoting Chronic Lymphocytic Leukemia
J. Exp. Med., August 16, 2004; 200(4): 519 - 525.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. D. Shanafelt, S. M. Geyer, and N. E. Kay
Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL
Blood, February 15, 2004; 103(4): 1202 - 1210.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
J. C. Byrd, S. Stilgenbauer, and I. W. Flinn
Chronic Lymphocytic Leukemia
Hematology, January 1, 2004; 2004(1): 163 - 183.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
Y. Vasconcelos, F. Davi, V. Levy, P. Oppezzo, C. Magnac, A. Michel, M. Yamamoto, O. Pritsch, H. Merle-Beral, K. Maloum, et al.
Binet's Staging System and VH Genes Are Independent but Complementary Prognostic Indicators in Chronic Lymphocytic Leukemia
J. Clin. Oncol., November 1, 2003; 21(21): 3928 - 3932.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
Z. A. Davis, J. A. Orchard, M. M. Corcoran, and D. G. Oscier
Divergence from the germ-line sequence in unmutated chronic lymphocytic leukemia is due to somatic mutation rather than polymorphisms
Blood, October 15, 2003; 102(8): 3075 - 3075.
[Full Text] [PDF]

Home page
 BloodHome page
D. Kienle, A. Krober, T. Katzenberger, G. Ott, E. Leupolt, T. F. E. Barth, P. Moller, A. Benner, A. Habermann, H. K. Muller-Hermelink, et al.
VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome
Blood, October 15, 2003; 102(8): 3003 - 3009.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. Lin, S. Manocha, R. J. Harris, Z. Matrai, P. D. Sherrington, and A. R. Pettitt
High frequency of p53 dysfunction and low level of VH mutation in chronic lymphocytic leukemia patients using the VH3-21 gene segment
Blood, August 1, 2003; 102(3): 1145 - 1146.
[Full Text] [PDF]

Home page
 BloodHome page
A. Guarini, G. Gaidano, F. R. Mauro, D. Capello, F. Mancini, M. S. De Propris, M. Mancini, E. Orsini, M. Gentile, M. Breccia, et al.
Chronic lymphocytic leukemia patients with highly stable and indolent disease show distinctive phenotypic and genotypic features
Blood, August 1, 2003; 102(3): 1035 - 1041.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. Wiestner, A. Rosenwald, T. S. Barry, G. Wright, R. E. Davis, S. E. Henrickson, H. Zhao, R. E. Ibbotson, J. A. Orchard, Z. Davis, et al.
ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile
Blood, June 15, 2003; 101(12): 4944 - 4951.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
G. Tobin, U. Thunberg, A. Johnson, I. Eriksson, O. Soderberg, K. Karlsson, M. Merup, G. Juliusson, J. Vilpo, G. Enblad, et al.
Chronic lymphocytic leukemias utilizing the VH3-21 gene display highly restricted V{lambda}2-14 gene use and homologous CDR3s: implicating recognition of a common antigen epitope
Blood, June 15, 2003; 101(12): 4952 - 4957.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
F. I. Camacho, P. Algara, A. Rodriguez, E. Ruiz-Ballesteros, M. Mollejo, N. Martinez, J. A. Martinez-Climent, M. Gonzalez, M. Mateo, A. Caleo, et al.
Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations
Blood, May 15, 2003; 101(10): 4042 - 4046.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
S. H. Walsh, M. Thorselius, A. Johnson, O. Soderberg, M. Jerkeman, E. Bjorck, I. Eriksson, U. Thunberg, O. Landgren, M. Ehinger, et al.
Mutated VH genes and preferential VH3-21 use define new subsets of mantle cell lymphoma
Blood, May 15, 2003; 101(10): 4047 - 4054.
[Abstract] [Full Text] [PDF]

Home page
 ASH Education BookHome page
M. J. Keating, N. Chiorazzi, B. Messmer, R. N. Damle, S. L. Allen, K. R. Rai, M. Ferrarini, a