SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Dalle, J. H. Articles by Quesnel, B. Search for Related Content PubMed PubMed Citation Articles by Dalle, J. H. Articles by Quesnel, B. Related Collections Neoplasia Oncogenes and Tumor Suppressors Brief Reports Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 April 2002, Vol. 99, No. 7, pp. 2620-2623 BRIEF REPORT p16INK4a immunocytochemical analysis is an independent prognostic factor in childhood acute lymphoblastic leukemia Jean Hughes Dalle, Martine Fournier, Brigitte Nelken, Françoise Mazingue, Jean-Luc Laï, Francis Bauters, Pierre Fenaux, and Bruno Quesnel From Service des Maladies du Sang, Centre Hospitalier et Universitaire Lille; 2-Service d'Hématologie Pédiatrique, Centre Hospitalier et Universitaire Lille; Laboratoire d'Hématologie, Centre Hospitalier et Universitaire Lille; Laboratoire de Cytogénétique, Centre Hospitalier et Universitaire Lille; Unité INSERM 524, Institut de Recherche sur le Cancer de Lille, Lille, France. We investigated the prognostic value of p16INK4a immunocytochemistry (ICC) analysis in 126 cases of newly diagnosed childhood acute lymphoblastic leukemia (ALL). The incidence of negative p16INK4a ICC was 38.1% and was more frequent in T-lineage ALL. Overall survival (OS) and event-free survival (EFS) were significantly higher in patients with positive p16INK4a ICC than in patients with negative ICC (6 years OS, 90% versus 63%, P = .0014; 6 years EFS, 77.8% versus 55%, P = .0033). The p16INK4a ICC remained a significant prognostic factor within the subgroup of B-precursor ALL. Multivariate analysis showed that negative p16INK4a ICC was an independent prognostic factor for OS (relative risk [RR], 3.38; P = .02) and EFS (RR, 2.49; P = .018). Sequential study showed that p16INK4a expression remained stable during first relapse in most patients. These findings indicate that p16INK4a ICC is an independent factor of outcome in childhood ALL. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: S. Sulong, A. V. Moorman, J. A. E. Irving, J. C. Strefford, Z. J. Konn, M. C. Case, L. Minto, K. E. Barber, H. Parker, S. L. Wright, et al. A comprehensive analysis of the CDKN2A gene in childhood acute lymphoblastic leukemia reveals genomic deletion, copy number neutral loss of heterozygosity, and association with specific cytogenetic subgroups Blood, January 1, 2009; 113(1): 100 - 107. [Abstract] [Full Text] [PDF] E. Grafstrom, S. Egyhazi, U. Ringborg, J. Hansson, and A. Platz Biallelic Deletions in INK4 in Cutaneous Melanoma Are Common and Associated with Decreased Survival Clin. Cancer Res., April 15, 2005; 11(8): 2991 - 2997. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020