|
|
 Previous Article | Table of Contents | Next Article 
Blood, 15 April 2002, Vol. 99, No. 8, pp. 3060-3062
BRIEF REPORT
Loss of PU.1 expression is associated with defective
immunoglobulin transcription in Hodgkin and Reed-Sternberg cells of
classical Hodgkin disease
Franziska Jundt,
Katharina Kley,
Ioannis Anagnostopoulos,
Kristina Schulze
Pröbsting,
Axel Greiner,
Stephan Mathas,
Claus Scheidereit,
Thomas Wirth,
Harald Stein, and
Bernd Dörken
From the Charité, Robert-Rössle-Klinik,
Humboldt University of Berlin, Germany; Max Delbrück Center for
Molecular Medicine, Berlin, Germany; Institute of Pathology, Klinikum
Benjamin Franklin, Free University of Berlin, Germany; Institute of
Pathology, University of Würzburg, Germany; Department of
Physiological Chemistry, University of Ulm, Germany
Immunoglobulin transcription is impaired in Hodgkin and
Reed-Sternberg (HRS) cells of classical Hodgkin disease (cHD). We recently demonstrated that defective immunoglobulin promoter
transcription correlates with the down-regulation of the B-cell
transcription factors Oct2 and BOB.1/OBF.1. These results prompted us
to investigate whether immunoglobulin enhancer activity is also
impaired in HRS cells and whether as yet unidentified factors could be
necessary for immunoglobulin enhancer activity in HRS cells of cHD.
Here we analyzed 30 cases of cHD for expression of the Ets family
member PU.1 that is known to collaborate with multiple transcription factors and to regulate expression of immunoglobulin genes. We show
that PU.1 is not expressed in primary and cultured HRS cells. Reintroduction of PU.1 and Oct2 in cultured HRS cells restored the
activity of cotransduced immunoglobulin enhancer constructs. Our study
identifies PU.1 deficiency as a recurrent defect in HRS cells that
might contribute to their impairment of immunoglobulin transcription.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
This article has been cited by other articles:
|
|
|
|
 
F. A. Scheeren, S. A. Diehl, L. A. Smit, T. Beaumont, M. Naspetti, R. J. Bende, B. Blom, K. Karube, K. Ohshima, C. J. M. van Noesel, et al.
IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis
Blood,
May 1, 2008;
111(9):
4706 - 4715.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G Kapatai and P Murray
Contribution of the Epstein Barr virus to the molecular pathogenesis of Hodgkin lymphoma
J. Clin. Pathol.,
December 1, 2007;
60(12):
1342 - 1349.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Chiu, W. Xu, B. He, S. R. Dillon, J. A. Gross, E. Sievers, X. Qiao, P. Santini, E. Hyjek, J.-w. Lee, et al.
Hodgkin lymphoma cells express TACI and BCMA receptors and generate survival and proliferation signals in response to BAFF and APRIL
Blood,
January 15, 2007;
109(2):
729 - 739.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ushmorov, F. Leithauser, O. Sakk, A. Weinhausel, S. W. Popov, P. Moller, and T. Wirth
Epigenetic processes play a major role in B-cell-specific gene silencing in classical Hodgkin lymphoma
Blood,
March 15, 2006;
107(6):
2493 - 2500.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. E. Coupland, C. Loddenkemper, J. R. Smith, R. M. Braziel, F. Charlotte, I. Anagnostopoulos, and H. Stein
Expression of Immunoglobulin Transcription Factors in Primary Intraocular Lymphoma and Primary Central Nervous System Lymphoma
Invest. Ophthalmol. Vis. Sci.,
November 1, 2005;
46(11):
3957 - 3964.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
P. S. Eis, W. Tam, L. Sun, A. Chadburn, Z. Li, M. F. Gomez, E. Lund, and J. E. Dahlberg
Accumulation of miR-155 and BIC RNA in human B cell lymphomas
PNAS,
March 8, 2005;
102(10):
3627 - 3632.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Ushmorov, O. Ritz, M. Hummel, F. Leithauser, P. Moller, H. Stein, and T. Wirth
Epigenetic silencing of the immunoglobulin heavy-chain gene in classical Hodgkin lymphoma-derived cell lines contributes to the loss of immunoglobulin expression
Blood,
November 15, 2004;
104(10):
3326 - 3334.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
A. Sanchez-Aguilera, J. Delgado, F. I. Camacho, M. Sanchez-Beato, L. Sanchez, C. Montalban, M. F. Fresno, C. Martin, M. A. Piris, and J. F. Garcia
Silencing of the p18INK4c gene by promoter hypermethylation in Reed-Sternberg cells in Hodgkin lymphomas
Blood,
March 15, 2004;
103(6):
2351 - 2357.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
K. J. Savage, S. Monti, J. L. Kutok, G. Cattoretti, D. Neuberg, L. de Leval, P. Kurtin, P. D. Cin, C. Ladd, F. Feuerhake, et al.
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma
Blood,
December 1, 2003;
102(12):
3871 - 3879.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Portis, P. Dyck, and R. Longnecker
Epstein-Barr Virus (EBV) LMP2A induces alterations in gene transcription similar to those observed in Reed-Sternberg cells of Hodgkin lymphoma
Blood,
December 1, 2003;
102(12):
4166 - 4178.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Swanson-Mungerson, M. Ikeda, L. Lev, R. Longnecker, and T. Portis
Identification of latent membrane protein 2A (LMP2A) specific targets for treatment and eradication of Epstein-Barr virus (EBV)-associated diseases
J. Antimicrob. Chemother.,
August 1, 2003;
52(2):
152 - 154.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S A Pileri, E Sabattini, S Ascani, P L Zinzani, and B Falini
How do we define Hodgkin's disease? The authors' reply
J. Clin. Pathol.,
February 1, 2003;
56(2):
159 - 159.
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Pileri, G. Gaidano, P. L. Zinzani, B. Falini, P. Gaulard, E. Zucca, F. Pieri, E. Berra, E. Sabattini, S. Ascani, et al.
Primary Mediastinal B-Cell Lymphoma: High Frequency of BCL-6 Mutations and Consistent Expression of the Transcription Factors OCT-2, BOB.1, and PU.1 in the Absence of Immunoglobulins
Am. J. Pathol.,
January 1, 2003;
162(1):
243 - 253.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
T. Portis and R. Longnecker
Epstein-Barr Virus LMP2A Interferes with Global Transcription Factor Regulation When Expressed during B-Lymphocyte Development
J. Virol.,
December 6, 2002;
77(1):
105 - 114.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
