SEARCH:   Advanced

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ezumi, Y. Articles by Takayama, H. Search for Related Content PubMed PubMed Citation Articles by Ezumi, Y. Articles by Takayama, H. Related Collections Hemostasis, Thrombosis, and Vascular Biology Signal Transduction Social Bookmarking                   What's this?  Previous Article  |  Table of Contents  |  Next Article  Blood, 1 May 2002, Vol. 99, No. 9, pp. 3250-3255 HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Constitutive and functional association of the platelet collagen receptor glycoprotein VI-Fc receptor -chain complex with membrane rafts Yasuharu Ezumi, Kumi Kodama, Takashi Uchiyama, and Hiroshi Takayama From the Department of Hematology and Oncology, Clinical Sciences for Pathological Organs, Graduate School of Medicine, Kyoto University, Japan. The platelet collagen receptor glycoprotein (GP) VI-Fc receptor -chain (FcR) complex transduces signals in an immunoreceptorlike manner. We examined a role for the Triton X-100-insoluble membrane rafts in GPVI-FcR complex signaling. Methyl--cyclodextrin (MCD)-induced disruption of the membrane rafts inhibited not only platelet aggregation and secretion but also tyrosine phosphorylation of signaling molecules on stimulation through the GPVI-FcR complex. The GPVI-FcR complex was constitutively associated with membrane rafts wherein the Src family kinases and LAT were also present. Their association was not affected by the complex engagement but was highly sensitive to MCD treatment. Thus, we provide the first evidence that the GPVI-FcR complex is constitutively and functionally associated with membrane rafts. © 2002 by The American Society of Hematology.   CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: F. A. Lee, M. van Lier, I. A. M. Relou, L. Foley, J.-W. N. Akkerman, H. F. G. Heijnen, and R. W. Farndale Lipid Rafts Facilitate the Interaction of PECAM-1 with the Glycoprotein VI-FcR {gamma}-Chain Complex in Human Platelets J. Biol. Chem., December 22, 2006; 281(51): 39330 - 39338. [Abstract] [Full Text] [PDF] J. M. Gibbins Platelet adhesion signalling and the regulation of thrombus formation J. Cell Sci., July 15, 2004; 117(16): 3415 - 3425. [Abstract] [Full Text] [PDF] S. Krishnan, M. P. Nambiar, V. G. Warke, C. U. Fisher, J. Mitchell, N. Delaney, and G. C. Tsokos Alterations in Lipid Raft Composition and Dynamics Contribute to Abnormal T Cell Responses in Systemic Lupus Erythematosus J. Immunol., June 15, 2004; 172(12): 7821 - 7831. [Abstract] [Full Text] [PDF] B. Nieswandt and S. P. Watson Platelet-collagen interaction: is GPVI the central receptor? Blood, July 15, 2003; 102(2): 449 - 461. [Abstract] [Full Text] [PDF] N. Watanabe, H. Nakajima, H. Suzuki, A. Oda, Y. Matsubara, M. Moroi, Y. Terauchi, T. Kadowaki, H. Suzuki, S. Koyasu, et al. Functional phenotype of phosphoinositide 3-kinase p85{alpha}-null platelets characterized by an impaired response to GP VI stimulation Blood, July 15, 2003; 102(2): 541 - 548. [Abstract] [Full Text] [PDF] C. N. Shrimpton, G. Borthakur, S. Larrucea, M. A. Cruz, J.-F. Dong, and J. A. Lopez Localization of the Adhesion Receptor Glycoprotein Ib-IX-V Complex to Lipid Rafts Is Required for Platelet Adhesion and Activation J. Exp. Med., October 21, 2002; 196(8): 1057 - 1066. [Abstract] [Full Text] [PDF]

	Copyright © 2002 by American Society of Hematology         Online ISSN: 1528-0020