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Blood, 15 December 2006, Vol. 108, No. 13, pp. 4275-4282. Prepublished online as a Blood First Edition Paper on August 22, 2006; DOI 10.1182/blood-2006-04-020313. This Article Full Text (PDF) All Versions of this Article: blood-2006-04-020313v1 108/13/4275    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Albano, M. S Articles by Stevens, C. E Search for Related Content PubMed PubMed Citation Articles by Albano, M. S Articles by Stevens, C. E Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 27, 2006 Accepted July 27, 2006 Umbilical cord blood transplantation and cytomegalovirus: post-transplant infection and donor screening Maria S Albano, Patricia Taylor, Robert F Pass, Andromachi Scaradavou, Rodica Ciubotariu, Carmelita Carrier, Ludy Dobrila, Pablo Rubinstein, and Cladd E Stevens* New York Blood Center Department of Pediatrics, UAB School of Medicine, 1600 7th Avenue South, Birmingham, AL * Corresponding author; email: cstevens{at}nybloodcenter.org. This study assessed the incidence of cytomegalovirus (CMV) infection after transplantation of cord blood (CB) from unrelated donors and evaluated strategies for screening CB donors. Post-transplant CMV infection, reported in 23% of 1221 CB recipients, was associated with patient pre-transplant CMV serology (p<0.001), but not with CMV serology in CB donors or their mothers. A total of 26,988 infant CB donors were evaluated by viral culture of saliva. Subgroups were evaluated by polymerase chain reaction in CB (CB-PCR) in two case-control studies. In the first study, 33 of 47 saliva culture positive CB donors were confirmed by CB-PCR. All mothers of the 33 infants with confirmed CMV infection were total-CMV antibody positive, but only 1/3 had IgM-CMV antibody. The second study evaluated infants born to mothers with IgM-CMV antibody. Of these, 5 of 170 saliva culture negative infants were positive by CB-PCR. Conclusions: The incidence of congenital CMV infection in CB donors was low (0.12%). Maternal serology had poor predictive value for CMV infection in their infant CB donors and bore no detected relationship to CMV infection in CB recipients. Saliva culture for CMV had both false positive and negative results. CB-PCR was a useful alternative for detecting CMV in CB donors. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Boeckh and P. Ljungman How we treat cytomegalovirus in hematopoietic cell transplant recipients Blood, June 4, 2009; 113(23): 5711 - 5719. [Abstract] [Full Text] [PDF]

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