Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
e-Letters
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 June 2007, Vol. 109, No. 11, pp. 4786-4792.
Prepublished online as a Blood First Edition Paper on February 15, 2007; DOI 10.1182/blood-2006-07-038539.

This Article
Right arrow Full Text (PDF)
Right arrow Supplemental Figures and Tables
Right arrow All Versions of this Article:
blood-2006-07-038539v1
109/11/4786    most recent
Right arrow e-Letter: Submit a Response
Right arrow Alert me when this article is cited
Right arrow Alert me when e-Letters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Coppinger, J. A
Right arrow Articles by Cagney, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Coppinger, J. A
Right arrow Articles by Cagney, G.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted July 31, 2006
Accepted January 29, 2007

Moderation of the platelet releasate response by aspirin

Judith A Coppinger, Roisin I O'Connor, Kieran Wynne, Michelle Flanagan, Matthew Sullivan, Patricia B Maguire, Desmond J Fitzgerald, and Gerard Cagney*

Dept of Cell Biology, Scripps Research Institute, La Jolla, CA, United States
School of Biomolecular & Biomedical Science, Conway Institute, University College Dublin, Dublin, Republic of Ireland
School of Medicine & Medical Science, University College Dublin, Dublin, Republic of Ireland
Proteome Research Center, Conway Institute, University College Dublin, Dublin, Republic of Ireland

* Corresponding author; email: gerard.cagney{at}ucd.ie.

Modulation of the proteins released during activation is one mechanism whereby aspirin may influence platelet-mediated human disease. We investigated the effect of aspirin on the platelet releasate using mass spectrometry and found that different agonists evoked different releasate profiles, with aspirin having a general moderating effect on the amount of protein released regardless of the agonist. These observations were confirmed for several cytokines using an antibody array approach.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Cancer Genomics ProteomicsHome page
R. Huang, W. Jiang, J. Yang, Y. Q. Mao, Y. Zhang, W. Yang, D. Yang, B. Burkholder, R. F. Huang, and R.-P. Huang
A Biotin Label-based Antibody Array for High-content Profiling of Protein Expression
Cancer Genomics Proteomics, May 1, 2010; 7(3): 129 - 141.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
F. Fouladkou, C. Lu, C. Jiang, L. Zhou, Y. She, J. R. Walls, H. Kawabe, N. Brose, R. M. Henkelman, A. Huang, et al.
The Ubiquitin Ligase Nedd4-1 Is Required for Heart Development and Is a Suppressor of Thrombospondin-1
J. Biol. Chem., February 26, 2010; 285(9): 6770 - 6780.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2007 by American Society of Hematology         Online ISSN: 1528-0020