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Blood, 15 August 2007, Vol. 110, No. 4, pp. 1330-1333. Prepublished online as a Blood First Edition Paper on May 11, 2007; DOI 10.1182/blood-2007-03-081133. This Article Full Text (PDF) Supplemental Methods, Tables, and Figures All Versions of this Article: blood-2007-03-081133v1 110/4/1330    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Loffler, D. Articles by Horn, F. Search for Related Content PubMed PubMed Citation Articles by Loffler, D. Articles by Horn, F. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted March 21, 2007 Accepted April 27, 2007 Interleukin-6-dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer Dennis Loffler, Katja Brocke-Heidrich, Gabriele Pfeifer, Claudia Stocsits, Jorg Hackermuller, Antje K. Kretzschmar, Renate Burger, Martin Gramatzki, Conny Blumert, Kay Bauer, Helena Cvijic, A. Kerstin Ullmann, Peter F. Stadler, and Friedemann Horn* Institute of Clinical Immunology and Transfusion Medicine, Medical Faculty, University of Leipzig, Leipzig, Germany Bioinformatics Group, Department of Computer Science, University of Leipzig, Leipzig, Germany Fraunhofer Institute of Cell Therapy and Immunology, Leipzig, Germany Division of Stem Cell Transplantation and Immunotherapy, 2nd Medical Department, University Hospital Schleswig-Holstein Campus Kiel, Kiel, Germany Interdisciplinary Center for Clinical Studies, University of Leipzig, Leipzig, Germany * Corresponding author; email: friedemann.horn{at}medizin.uni-leipzig.de. Signal transducer and activator of transcription 3 (Stat3) is implicated in the pathogenesis of many malignancies and essential for IL-6-dependent survival and growth of multiple myeloma cells. Here, we demonstrate that the gene encoding oncogenic microRNA-21 (miR-21) is controlled by an upstream enhancer containing two Stat3 binding sites strictly conserved since the first observed evolutionary appearance of miR-21 and Stat3. MiR-21 induction by IL-6 was strictly Stat3-dependent. Ectopically raising miR-21 expression in myeloma cells in the absence of IL-6 significantly reduced their apoptosis levels. These data provide strong evidence that miR-21 induction contributes to the oncogenic potential of Stat3. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The STATus of miR-21 in apoptosis Elaine M. Hurt and William L. Farrar Blood 2007 110: 1086-1087. [Full Text] [PDF] This article has been cited by other articles: T.-H. Huang, F. Wu, G. B. Loeb, R. Hsu, A. Heidersbach, A. Brincat, D. Horiuchi, R. J. Lebbink, Y.-Y. Mo, A. Goga, et al. Up-regulation of miR-21 by HER2/neu Signaling Promotes Cell Invasion J. 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