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Blood, 18 June 2009, Vol. 113, No. 25, pp. 6386-6391. Prepublished online as a Blood First Edition Paper on April 22, 2009; DOI 10.1182/blood-2009-02-203471. This Article Full Text (PDF) All Versions of this Article: blood-2009-02-203471v1 113/25/6386    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Landgren, O. Articles by Alavanja, M. C. Search for Related Content PubMed PubMed Citation Articles by Landgren, O. Articles by Alavanja, M. C. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted February 3, 2009 Accepted April 16, 2009 Pesticide exposure and risk of monoclonal gammopathy of undetermined significance (MGUS) in the Agricultural Health Study Ola Landgren*, Robert A. Kyle, Jane A. Hoppin, Laura E. Beane Freeman, James R. Cerhan, Jerry A. Katzmann, S. Vincent Rajkumar, and Michael C. Alavanja Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, United States College of Medicine, Mayo Clinic, Rochester, MN, United States National Institute of Environmental Health Sciences, NIH, Research Triangle Park, NC, United States * Corresponding author; email: landgreo{at}mail.nih.gov. Pesticides have been associated with excess risk of multiple myeloma (MM), albeit inconclusively. We included 678 men (30-94 years) from a well-characterized prospective cohort of restricted use pesticide applicators to assess the risk of monoclonal gammopathy of undetermined significance (MGUS). Serum samples from all subjects were analyzed by electrophoresis performed on agarose gel; samples with a discrete or localized band were subjected to immunofixation. Age-adjusted prevalence estimates of MGUS were compared with MGUS prevalence in 9,469 men from Minnesota. Associations between pesticide exposures and MGUS prevalence were assessed by logistic regression models adjusted for age and education level. Among study participants >50 years (n=555), 38 were found to have MGUS, yielding a prevalence of 6.8% (5.0-9.3). Compared with men from Minnesota, the age-adjusted prevalence of MGUS was 1.9-fold (1.3-2.7) higher among male pesticide applicators. Among applicators, a 5.6-fold (1.9-16.6), 3.9-fold (1.5-10.0), and 2.4-fold (1.1-5.3) increased risk of MGUS was observed among users of the chlorinated insecticide dieldrin, the fumigant mixture carbon-tetrachloride/carbon disulfide, and the fungicide chlorothalonil, respectively. In summary, the prevalence of MGUS among pesticide applicators was twice that in a population-based sample of men from Minnesota, adding support to the hypothesis that specific pesticides are etiologically linked to myelomagenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. A. Kyle and S. Kumar The significance of monoclonal gammopathy of undetermined significance Haematologica, December 1, 2009; 94(12): 1641 - 1644. [Full Text] [PDF]

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