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Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-232124. This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Google Scholar Articles by Moorman, A. V Articles by Proctor, S. J PubMed PubMed Citation Articles by Moorman, A. V Articles by Proctor, S. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 8, 2009; accepted October 11, 2009. A population based cytogenetic study of adults with acute lymphoblastic leukaemia (ALL) Anthony V Moorman1,4, Lucy Chilton1, Jennifer Wilkinson2, Hannah M Ensor1, Nick Bown3 and Stephen J Proctor2 1 Northern Institute for Cancer Research, Newcastle University, Newcastle-upon-Tyne, United Kingdom; 2 Department of Haematology, Royal Victoria Infirmary, Newcastle-upon-Tyne, United Kingdom; 3 NHS Northern Genetics Service, Newcastle-upon-Tyne, United Kingdom * Corresponding author; email: anthony.moorman{at}ncl.ac.uk Abstract Chromosomal abnormalities are increasingly used to risk stratify adults with ALL. Published data describing the age-specific incidence of chromosomal abnormalities and their prognostic relevance is largely derived from clinical trials. Trials frequently have age restrictions and low recruitment rates. Thus we investigated these factors in a population-based cohort of 349 patients diagnosed over 19 years in the North of the UK. The incidence of most chromosomal abnormalities varied significantly with age. The incidence of t(9;22)(q34;q11) increased in each successive decade, up to 24% among 40-49 year olds. Thereafter the incidence reached a plateau. t(4;11)(q21;q23) and t(1;19)(q23;p13) were rare among patients aged over 60 years. In contrast, t(8;14)(q24;q32) and t(14;18)(q32;q21) increased with age. High hyperdiploidy occurred in 13% of patients <20 years but in only 5% of older patients. The incidence of low hypodiploidy / near-triploidy (HoTr) and complex karyotype increased with age from 4% (15-29 years) to 15% (60+ years). Overall survival varied significantly by age and cytogenetics. Older patients and those with t(9;22), t(4;11), Ho-Tr or complex karyotype had a significantly inferior outcome. These population-based results demonstrate the cytogenetic heterogeneity of adult ALL. These data will inform service planning and the design of new age-focussed clinical trials. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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