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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nishii, K. Articles by Shiku, H. Search for Related Content PubMed PubMed Citation Articles by Nishii, K. Articles by Shiku, H. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Table of Contents Blood, 1 November 2002, Vol. 100, No. 9, pp. 3436-3436 CORRESPONDENCE To the editor: Adult acute myeloid leukemia cells do not express nonfunctional Ikaros isoforms We read with great interest the article by Yagi et al1 on the expression of nonfunctional Ikaros isoform 6 (Ik6) in childhood acute myeloid leukemia (AML). The authors reported that Ik6 was expressed in 7 of 10 cases of M4 and M5 AML (French-American-British [FAB] classification), but in none with M2 and M7 AML. Their M4 and M5 cases with Ik6 expression had karyotype abnormalities: inv(16), inv(6), inv(9), del(11), +6, +8, +18, +21, or t(9;11). We also determined whether Ik6 was expressed in samples from 24 Japanese adults with AML using reverse transcriptase-polymerase chain reaction2; 7 cases of M1, 5 of M2, 2 of M3, 5 with cessation of M4, and 5 with cessation of M5. As shown in Table 1, all AML samples expressed Ik1 and/or Ik2 but not Ik6. Abnormal karyotypes inv(16) (cases 17 and 18) and +8 (case 15) were also found in adult AML M4 cases; however, expression of Ik6 was not detected in these cases of AML. These findings indicate that Ik6 is expressed in childhood AML but not in adult AML, and that expression of Ik6 in AML is apparently not associated with karyotypes. Several reports demonstrated that Ik6 is frequently expressed in B-precursor acute lymphoblastic leukemia (pre-B ALL) in infants, young children,3-6 and adults, and in childhood pre-T ALL.7 We reported that Ik6 was detected in 16 of 36 patients with adult pre-B ALL but not in adult pre-T ALL.2                                View this table: [in this window] [in a new window]   Table 1. Expression of Ikaros isoforms in adult AML Although the role of nonfunctional Ikaros isoforms in leukemogenic mechanisms is not fully understood, it should be kept in mind that the expression manner of IK-6 differs in adult, childhood, and infant acute leukemias. Kazuhiro Nishii, Naoyuki Katayama, and Hiroshi Shiku Correspondence: Kazuhiro Nishii, the Second Department of Internal Medicine, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan; e-mail: kaz{at}clin.medic.mie-u.ac.jp Acknowledgments Supported by research grants from the Ministry of Education, Culture, Sports, Science, and Technology from the Ministry of Health, Labour, and Welfare, Tokyo, Japan. References 1. Yagi T, Hibi S, Takanashi M, et al. High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis. Blood. 2002;99:1350-1355[Abstract/Free Full Text]. 2. Nishii K, Katayama N, Miwa H, et al. Non-DNA-binding Ikaros isoform gene expressed in adult B-precursor acute lymphoblastic leukemia. Leukemia. 2002;16:1285-1292[CrossRef][Medline] [Order article via Infotrieve]. 3. Sun L, Heerema N, Crotty L, et al. Expression of dominant-negative and mutant isoforms of the antileukemic transcription factor Ikaros in infant acute lymphoblastic leukemia. Proc Natl Acad Sci USA. 1999;96:680-685[Abstract/Free Full Text]. 4. Sun L, Goodman PA, Wood CM, et al. Expression of aberrantly spliced oncogenic Ikaros isoforms in childhood acute lymphoblastic leukemia. J Clin Oncol. 1999;17:3753-3766[Abstract/Free Full Text]. 5. Nakase K, Ishimaru F, Avitahl N, et al. Dominant negative isoform of the Ikaros gene in patients with adult B-cell acute lymphoblastic leukemia. Cancer Res. 2000;60:4062-4065[Abstract/Free Full Text]. 6. Olivero S, Maroc C, Beillard E, et al. Detection of different Ikaros isoforms in human leukaemias using real-time quantitative polymerase chain reaction. Br J Haematol 2000;110:826-830[CrossRef][Medline] [Order article via Infotrieve]. 7. Sun L, Crotty M-L, Sensel M, et al. Expression of dominant-negative Ikaros isoforms in T-cell acute lymphoblastic leukemia. Clin Cancer Res. 1999;7:2112-2120. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: High frequency of Ikaros isoform 6 expression in acute myelomonocytic and monocytic leukemias: implications for up-regulation of the antiapoptotic protein Bcl-XL in leukemogenesis Tomohito Yagi, Shigeyoshi Hibi, Mami Takanashi, Gen Kano, Yasuhiro Tabata, Toshihiko Imamura, Tohru Inaba, Akira Morimoto, Shinjiro Todo, and Shinsaku Imashuku Blood 2002 99: 1350-1355. [Abstract] [Full Text] [PDF] This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Nishii, K. Articles by Shiku, H. Search for Related Content PubMed PubMed Citation Articles by Nishii, K. Articles by Shiku, H. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?

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